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Peer-reviewedCC BY 4.0Frontiers in Immunology

Stem cell factor in allergic diseases: mechanisms of type 2 immunity and therapeutic opportunities

  • Ramon Ocadiz-Ruiz1
  • Sarita Montaño1
  • Nicholas W. Lukacs1,2
  • Wendy Fonseca1
  1. 1Department of Pathology, University of Michigan Medical School
  2. 2Mary H. Weiser Food Allergy Center, University of Michigan
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Abstract

Stem cell factor (SCF) and its receptor c-Kit regulate the development, survival, tissue localization, and activation of several immune populations central to allergic disease. This review examines how the SCF220 and SCF248 isoforms shape c-Kit signaling in mast cells, group 2 innate lymphoid cells, eosinophils, dendritic cells, and basophils; how stromal and epithelial sources of SCF sustain allergic inflammation; and how this pathway contributes to disease severity and tissue remodeling. We also discuss the therapeutic potential and limitations of targeting SCF, or specific SCF isoforms, in allergic disease.

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Cite

BibTeXRIS
BibTeX
@article{ocadizruiz2026stem,
  title = {{Stem cell factor in allergic diseases: mechanisms of type 2 immunity and therapeutic opportunities}},
  author = {Ramon Ocadiz-Ruiz and Sarita Montaño and Nicholas W. Lukacs and Wendy Fonseca},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.2009363},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.2009363/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Stem cell factor in allergic diseases: mechanisms of type 2 immunity and therapeutic opportunities
AU  - Ramon Ocadiz-Ruiz
AU  - Sarita Montaño
AU  - Nicholas W. Lukacs
AU  - Wendy Fonseca
PY  - 2026
DA  - 2026/10/29
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.2009363
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.2009363/full
AB  - Stem cell factor (SCF) and its receptor c-Kit regulate the development, survival, tissue localization, and activation of several immune populations central to allergic disease. This review examines how the SCF220 and SCF248 isoforms shape c-Kit signaling in mast cells, group 2 innate lymphoid cells, eosinophils, dendritic cells, and basophils; how stromal and epithelial sources of SCF sustain allergic inflammation; and how this pathway contributes to disease severity and tissue remodeling. We also discuss the therapeutic potential and limitations of targeting SCF, or specific SCF isoforms, in allergic disease.
SN  - 1664-3224
ER  -