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Peer-reviewedCC BY 4.0PLOS Medicine

The widening medication adherence gap

  • Zachary A. Marcum1
  1. 1Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, United States of America
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Abstract

The gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. Closing this gap requires more than individual behavior change; it requires system-level solutions, including coverage and funding design, pharmacist-led programs, and health information technology.

In this Perspective, Zachary Marcum argues that the gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. He discusses why closing this gap requires not just individual behavior change, but system-level solutions.

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Cite

BibTeXRIS
BibTeX
@article{marcum2026widening,
  title = {{The widening medication adherence gap}},
  author = {Zachary A. Marcum},
  journal = {PLOS Medicine},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pmed.1005237},
  url = {https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005237},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The widening medication adherence gap
AU  - Zachary A. Marcum
PY  - 2026
DA  - 2026/09/04
JO  - PLOS Medicine
DO  - 10.1371/journal.pmed.1005237
UR  - https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1005237
AB  - The gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. Closing this gap requires more than individual behavior change; it requires system-level solutions, including coverage and funding design, pharmacist-led programs, and health information technology.  In this Perspective, Zachary Marcum argues that the gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. He discusses why closing this gap requires not just individual behavior change, but system-level solutions.
SN  - 1549-1676
ER  -