5-Aminosalicylic Acid-induced Colitis in a Patient with Rheumatoid Arthritis without Inflammatory Bowel Disease
Abstract
This report presents a rare case of 5-aminosalicylic acid (5-ASA)-induced colitis in a 76-year-old man with no history of inflammatory bowel disease (IBD). The patient, who was undergoing treatment for rheumatoid arthritis, developed persistent diarrhea and fever following sulfasalazine (SASP) administration and later experienced a high fever shortly after taking mesalazine. The drug-induced lymphocyte stimulation test result was positive for mesalazine and weakly positive for SASP, thereby supporting the diagnosis of 5-ASA intolerance. This case emphasizes that 5-ASA-induced colitis may occur in patients without IBD. Clinicians should consider this possibility when unexplained gastrointestinal symptoms appear after starting 5-ASA therapy even in patients without any prior IBD.
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BibTeX
@article{izumi20265aminosalicylic,
title = {{5-Aminosalicylic Acid-induced Colitis in a Patient with Rheumatoid Arthritis without Inflammatory Bowel Disease}},
author = {Ryosuke Izumi and Issei Hirata and Yuta Hattori and Yuki Shirane and Hirosato Tamari and Teruo Mori and Makoto Higashiyama and Yoshio Kuga and Takashi Moriya},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.6411-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6411-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - 5-Aminosalicylic Acid-induced Colitis in a Patient with Rheumatoid Arthritis without Inflammatory Bowel Disease
AU - Ryosuke Izumi
AU - Issei Hirata
AU - Yuta Hattori
AU - Yuki Shirane
AU - Hirosato Tamari
AU - Teruo Mori
AU - Makoto Higashiyama
AU - Yoshio Kuga
AU - Takashi Moriya
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6411-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6411-25/_article
AB - This report presents a rare case of 5-aminosalicylic acid (5-ASA)-induced colitis in a 76-year-old man with no history of inflammatory bowel disease (IBD). The patient, who was undergoing treatment for rheumatoid arthritis, developed persistent diarrhea and fever following sulfasalazine (SASP) administration and later experienced a high fever shortly after taking mesalazine. The drug-induced lymphocyte stimulation test result was positive for mesalazine and weakly positive for SASP, thereby supporting the diagnosis of 5-ASA intolerance. This case emphasizes that 5-ASA-induced colitis may occur in patients without IBD. Clinicians should consider this possibility when unexplained gastrointestinal symptoms appear after starting 5-ASA therapy even in patients without any prior IBD.
SN - 1349-7235
SN - 0918-2918
ER -