1,3,4-Oxadiazole-sulfonamide hybrids: recent advances in biological activities, structure-activity relationships, and therapeutic applications.
4 affiliations
- 1Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University Minia 61519 Egypt [email protected].
- 2Medicinal Chemistry Department, Faculty of Pharmacy, Minia National University New Minia 61768 Egypt.
- 3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University 82524 Sohag Egypt [email protected] [email protected] (002)-01018384461.
- 4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University 82524 Sohag Egypt.
Abstract
Molecular hybridization has emerged as an effective strategy in medicinal chemistry for the development of multifunctional therapeutic agents with improved biological performance. Among the various hybrid scaffolds investigated, 1,3,4-oxadiazole-sulfonamide hybrids have gained considerable attention owing to the complementary pharmacological properties of both pharmacophores. The integration of the 1,3,4-oxadiazole nucleus and sulfonamide moiety within a single molecular framework has generated structurally diverse compounds exhibiting promising activities against a broad range of biological targets. This review provides a comprehensive overview of the biological activities and structure-activity relationships (SARs) of 1,3,4-oxadiazole-sulfonamide hybrids reported over the past two decades. Particular emphasis is placed on their antimicrobial, anticancer, anti-Alzheimer, anti-HIV, antidiabetic, anti-inflammatory, antioxidant, antimalarial, anti-glaucoma, and carbonic anhydrase inhibitory activities. Furthermore, the influence of key structural modifications on biological performance is critically discussed, highlighting the pharmacophoric features and substitution patterns associated with enhanced potency and selectivity. Collectively, the available evidence demonstrates the remarkable therapeutic versatility of 1,3,4-oxadiazole-sulfonamide hybrids and supports their continued exploration as promising scaffolds for future drug discovery and development.
Related
- ROLE OF HETEROCYCLIC SCAFFOLDS IN MODERN DRUG DESIGN: STRUCTURE–ACTIVITY RELATIONSHIPS, THERAPEUTIC APPLICATIONS AND EMERGING COMPUTATIONAL APPROACHES
- Design and synthesis of 2,5-di(pyridin-4-yl)-1,3,4-oxadiazole: structural elucidation, DFT insights, and preliminary in silico biological evaluation
- Recent Advances in Polysaccharides from Sophora flavescens Ait.: Extraction, Purification, Structural Characteristics, Pharmacological Effects, Structure-Activity Relationships, and Potential Applications
- Structure–function relationships in a square-planar Cu(ii) hybrid halometalate: experimental, DFT, molecular docking, optical, and biological studies
- Benzoxazole–benzamide hybrids: synthesis, structure–activity relationships, and multi-biological evaluation
BibTeX
@article{hosney2026134oxadiazolesulfonamide,
title = {{1,3,4-Oxadiazole-sulfonamide hybrids: recent advances in biological activities, structure-activity relationships, and therapeutic applications.}},
author = {Alshaimaa Hosney and El-Shimaa M N Abdelhafez and Mamdouh F A Mohamed},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07323a},
url = {https://europepmc.org/article/MED/42835984},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - 1,3,4-Oxadiazole-sulfonamide hybrids: recent advances in biological activities, structure-activity relationships, and therapeutic applications.
AU - Alshaimaa Hosney
AU - El-Shimaa M N Abdelhafez
AU - Mamdouh F A Mohamed
PY - 2026
DA - 2026/10/05
JO - RSC advances
DO - 10.1039/d6ra07323a
UR - https://europepmc.org/article/MED/42835984
AB - Molecular hybridization has emerged as an effective strategy in medicinal chemistry for the development of multifunctional therapeutic agents with improved biological performance. Among the various hybrid scaffolds investigated, 1,3,4-oxadiazole-sulfonamide hybrids have gained considerable attention owing to the complementary pharmacological properties of both pharmacophores. The integration of the 1,3,4-oxadiazole nucleus and sulfonamide moiety within a single molecular framework has generated structurally diverse compounds exhibiting promising activities against a broad range of biological targets. This review provides a comprehensive overview of the biological activities and structure-activity relationships (SARs) of 1,3,4-oxadiazole-sulfonamide hybrids reported over the past two decades. Particular emphasis is placed on their antimicrobial, anticancer, anti-Alzheimer, anti-HIV, antidiabetic, anti-inflammatory, antioxidant, antimalarial, anti-glaucoma, and carbonic anhydrase inhibitory activities. Furthermore, the influence of key structural modifications on biological performance is critically discussed, highlighting the pharmacophoric features and substitution patterns associated with enhanced potency and selectivity. Collectively, the available evidence demonstrates the remarkable therapeutic versatility of 1,3,4-oxadiazole-sulfonamide hybrids and supports their continued exploration as promising scaffolds for future drug discovery and development.
SN - 2046-2069
ER -