Peer-reviewedCC BYFrontiers in cardiovascular medicine11 Sep 2026

Evolution of right ventricular contraction patterns of adult heart transplant recipients by three-dimensional echocardiography.

Yuji Xie^1,2,3
Wei Sun^1,2,3
Linyue Zhang^1,2,3
Yanting Zhang^1,2,3
Shuangshuang Zhu^1,2,3
Yun Yang^1,2,3
Xin Zhang^1,2,3
Sushan Xiao^1,2,3
Liqiong Shi^1,2,3
Qing Lv^1,2,3
Yuman Li^1,2,3
Chun Wu^1,2,3

2 more authors

Li Zhang^1,2,3
Mingxing Xie^1,2,3

¹Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
²Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, Hubei, China.
³Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China.

Abstract

Background

The right ventricular contractile pattern is altered after heart transplantation (HT). This study aims to use three-dimensional echocardiography (3DE) to comprehensively assess right ventricular contractile pattern in HT patients.Methods

In a cohort of 200 adult HT recipients, we serially assessed 3DE RV contraction patterns-including global (RVEF), longitudinal (LEF), radial (REF), and anteroposterior (AEF) ejection fractions-from the early post-operative period to 3 years. 50 HT patients were compared to matched healthy controls and open-heart surgery patients. Sex-specific reference values were derived.Results

RV function parameters improved within the first year (all P < 0.05), then stabilized. At 1 year, HT recipients exhibited a distinct 3D contraction pattern compared to controls: attenuated longitudinal and anteroposterior function (LEF: 18.2% vs. 28.6%; AEF: 23.8% vs. 25.4%; P < 0.05) with compensatory enhanced radial contraction (REF: 29.8% vs. 24.6%; P < 0.05). Established reference ranges confirmed this phenotype. Cardiopulmonary bypass time were key determinants of this pattern.Conclusions

HT recipients develop a unique, stabilized RV contraction pattern by one year, characterized by a shift from longitudinal to radial dominance.

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Cite

BibTeX RIS

BibTeX

@article{xie2026evolution,
  title = {{Evolution of right ventricular contraction patterns of adult heart transplant recipients by three-dimensional echocardiography.}},
  author = {Yuji Xie and Wei Sun and Linyue Zhang and Yanting Zhang and Shuangshuang Zhu and Yun Yang and Xin Zhang and Sushan Xiao and Liqiong Shi and Qing Lv and Yuman Li and Chun Wu and Li Zhang and Mingxing Xie},
  journal = {Frontiers in cardiovascular medicine},
  year = {2026},
  month = sep,
  doi = {10.3389/fcvm.2026.1885027},
  url = {https://europepmc.org/article/MED/42840949},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Evolution of right ventricular contraction patterns of adult heart transplant recipients by three-dimensional echocardiography.
AU  - Yuji Xie
AU  - Wei Sun
AU  - Linyue Zhang
AU  - Yanting Zhang
AU  - Shuangshuang Zhu
AU  - Yun Yang
AU  - Xin Zhang
AU  - Sushan Xiao
AU  - Liqiong Shi
AU  - Qing Lv
AU  - Yuman Li
AU  - Chun Wu
AU  - Li Zhang
AU  - Mingxing Xie
PY  - 2026
DA  - 2026/09/11
JO  - Frontiers in cardiovascular medicine
DO  - 10.3389/fcvm.2026.1885027
UR  - https://europepmc.org/article/MED/42840949
AB  - Background  The right ventricular contractile pattern is altered after heart transplantation (HT). This study aims to use three-dimensional echocardiography (3DE) to comprehensively assess right ventricular contractile pattern in HT patients.Methods  In a cohort of 200 adult HT recipients, we serially assessed 3DE RV contraction patterns-including global (RVEF), longitudinal (LEF), radial (REF), and anteroposterior (AEF) ejection fractions-from the early post-operative period to 3 years. 50 HT patients were compared to matched healthy controls and open-heart surgery patients. Sex-specific reference values were derived.Results  RV function parameters improved within the first year (all P < 0.05), then stabilized. At 1 year, HT recipients exhibited a distinct 3D contraction pattern compared to controls: attenuated longitudinal and anteroposterior function (LEF: 18.2% vs. 28.6%; AEF: 23.8% vs. 25.4%; P < 0.05) with compensatory enhanced radial contraction (REF: 29.8% vs. 24.6%; P < 0.05). Established reference ranges confirmed this phenotype. Cardiopulmonary bypass time were key determinants of this pattern.Conclusions  HT recipients develop a unique, stabilized RV contraction pattern by one year, characterized by a shift from longitudinal to radial dominance.
SN  - 2297-055X
ER  -

Abstract

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