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Peer-reviewedCC BY-NC 4.0Journal of Neurogastroenterology and Motility

Mortality in Irritable Bowel Syndrome: The Tohoku Medical Megabank Project Community-Based Cohort Study

  • Kumi Nakaya1,2
  • Naoki Nakaya1,2
  • Mana Kogure1,2
  • Rieko Hatanaka1,2
  • Ippei Chiba1,2
  • Masato Takase1,2
  • Sayuri Tokioka1,2
  • Taku Obara1,2
  • Satoshi Nagaie1,2
  • Tomohiro Nakamura1,2,3
  • Motoyori Kanazawa2
  • Soichi Ogishima1,2
4 more authors
  • Nobuo Fuse1,2
  • Yoko Izumi1,2
  • Shin Fukudo2
  • Atsushi Hozawa1,2
  1. 1Tohoku Medical Megabank Organization, Tohoku University Sendai Japan
  2. 2Graduate School of Medicine, Tohoku University, Sendai, Japan; and Kyoto Japan
  3. 3Faculty of Data Science, Kyoto Women’s University Kyoto Japan
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Abstract

Background/Aims: This prospective cohort study involving participants from the Miyagi part of the Tohoku Medical Megabank Project Community-Based Cohort Study investigates the association between irritable bowel syndrome, including not consulted medical care, and all-cause mortality.

Methods: A total of 15354 participants were followed up through 2021. Irritable bowel syndrome was identified using the Rome II modular questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality were estimated using multivariate Cox proportional hazards regression models. Additional analysis was performed according to sex, irritable bowel syndrome subtype, baseline and second period surveys, and health checkup attendance within 1 year.

Results: A total of 2818 participants (18.4%) had irritable bowel syndrome at baseline. During a median follow-up of 6.7 years, 311 participants died. No significant differences in mortality were observed between those with and without irritable bowel syndrome (HR, 0.94; 95% CI, 0.68–1.29). Similar results were observed based on sex, subtype, and irritable bowel syndrome status in both surveys. Participants with irritable bowel syndrome who did not attend a health checkup within the previous year had observed higher mortality (HR, 2.11; 95% CI, 1.06–4.19) compared with those without it who attended a health checkup. The risk of death was not significantly increased in participants with irritable bowel syndrome who attended health checkups.

Conclusions: Irritable bowel syndrome, identified by self-reporting using the Rome II questionnaire, was not associated with all-cause mortality. Nonetheless, results suggest individuals with irritable bowel syndrome who did not undergo health checkups may have had higher overall mortality.

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Cite

BibTeXRIS
BibTeX
@article{nakaya2026mortality,
  title = {{Mortality in Irritable Bowel Syndrome: The Tohoku Medical Megabank Project Community-Based Cohort Study}},
  author = {Kumi Nakaya and Naoki Nakaya and Mana Kogure and Rieko Hatanaka and Ippei Chiba and Masato Takase and Sayuri Tokioka and Taku Obara and Satoshi Nagaie and Tomohiro Nakamura and Motoyori Kanazawa and Soichi Ogishima and Nobuo Fuse and Yoko Izumi and Shin Fukudo and Atsushi Hozawa},
  journal = {Journal of Neurogastroenterology and Motility},
  year = {2026},
  month = oct,
  doi = {10.5056/jnm25142},
  url = {https://doi.org/10.5056/jnm25142},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Mortality in Irritable Bowel Syndrome: The Tohoku Medical Megabank Project Community-Based Cohort Study
AU  - Kumi Nakaya
AU  - Naoki Nakaya
AU  - Mana Kogure
AU  - Rieko Hatanaka
AU  - Ippei Chiba
AU  - Masato Takase
AU  - Sayuri Tokioka
AU  - Taku Obara
AU  - Satoshi Nagaie
AU  - Tomohiro Nakamura
AU  - Motoyori Kanazawa
AU  - Soichi Ogishima
AU  - Nobuo Fuse
AU  - Yoko Izumi
AU  - Shin Fukudo
AU  - Atsushi Hozawa
PY  - 2026
DA  - 2026/10/31
JO  - Journal of Neurogastroenterology and Motility
DO  - 10.5056/jnm25142
UR  - https://doi.org/10.5056/jnm25142
AB  - Background/Aims: This prospective cohort study involving participants from the Miyagi part of the Tohoku Medical Megabank Project Community-Based Cohort Study investigates the association between irritable bowel syndrome, including not consulted medical care, and all-cause mortality.  Methods: A total of 15354 participants were followed up through 2021. Irritable bowel syndrome was identified using the Rome II modular questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality were estimated using multivariate Cox proportional hazards regression models. Additional analysis was performed according to sex, irritable bowel syndrome subtype, baseline and second period surveys, and health checkup attendance within 1 year.  Results: A total of 2818 participants (18.4%) had irritable bowel syndrome at baseline. During a median follow-up of 6.7 years, 311 participants died. No significant differences in mortality were observed between those with and without irritable bowel syndrome (HR, 0.94; 95% CI, 0.68–1.29). Similar results were observed based on sex, subtype, and irritable bowel syndrome status in both surveys. Participants with irritable bowel syndrome who did not attend a health checkup within the previous year had observed higher mortality (HR, 2.11; 95% CI, 1.06–4.19) compared with those without it who attended a health checkup. The risk of death was not significantly increased in participants with irritable bowel syndrome who attended health checkups.  Conclusions: Irritable bowel syndrome, identified by self-reporting using the Rome II questionnaire, was not associated with all-cause mortality. Nonetheless, results suggest individuals with irritable bowel syndrome who did not undergo health checkups may have had higher overall mortality.
SN  - 2093-0879
SN  - 2093-0887
ER  -