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Peer-reviewedCC BY-NCPlant Stress

Distinct regulatory networks mediate plant adaptation to multifactorial abiotic stress combinations: rethinking of plant stress genetics

  • Ali Raza1,2
  • Yiran Li1,2
  • Mengkai Zhao1,2
  • Tao Ming1,2
  • Rodomiro Octavio Ortiz3
  • Robert James Henry4,5
  • Zhangli Hu1,6,2
6 affiliations
  1. 1Guangdong Key Laboratory of Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
  2. 2Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Guangdong Technology Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
  3. 3Department of Plant Breeding, Swedish University of Agricultural Sciences, Alnarp, Sweden
  4. 4Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, QLD, 4072, Australia
  5. 5VinUni Big Data Institute VinUniversity, Hanoi, Vietnam
  6. 6Hunan University of Arts and Science, Hunan Innovation Center for Synthetic Biomanufacturing Industry, Changde 415000, China
Open at sourceDOICite

Abstract

Plants in natural environments often encounter multifactorial abiotic stress combinations that trigger regulatory responses distinct from those triggered by individual stresses. Traditional single-stress paradigms inadequately capture these complex interactions, limiting crop improvement efforts. Here, we discuss how plants integrate conserved signaling pathways with combination-specific regulatory modules (CSRMs) across multiple regulatory layers to mediate stress tolerance. Using recent findings, including the identification of specific transcription factor complexes that decode unique stress combinations, we highlight how CSRMs coordinate downstream protective pathways such as reactive oxygen species buffering. These insights suggest a multi-layered regulatory logic underlying plant adaptation to combined stresses. Leveraging CSRMs through integrative discovery and engineering approaches offers a promising avenue for developing climate-smart crops with potentially enhanced and stable tolerance under unpredictable field conditions.

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Cite

BibTeXRIS
BibTeX
@article{raza2026distinct,
  title = {{Distinct regulatory networks mediate plant adaptation to multifactorial abiotic stress combinations: rethinking of plant stress genetics}},
  author = {Ali Raza and Yiran Li and Mengkai Zhao and Tao Ming and Rodomiro Octavio Ortiz and Robert James Henry and Zhangli Hu},
  journal = {Plant Stress},
  year = {2026},
  month = jun,
  doi = {10.1016/j.stress.2026.101458},
  url = {https://doi.org/10.1016/j.stress.2026.101458},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Distinct regulatory networks mediate plant adaptation to multifactorial abiotic stress combinations: rethinking of plant stress genetics
AU  - Ali Raza
AU  - Yiran Li
AU  - Mengkai Zhao
AU  - Tao Ming
AU  - Rodomiro Octavio Ortiz
AU  - Robert James Henry
AU  - Zhangli Hu
PY  - 2026
DA  - 2026/06/26
JO  - Plant Stress
DO  - 10.1016/j.stress.2026.101458
UR  - https://doi.org/10.1016/j.stress.2026.101458
AB  - Plants in natural environments often encounter multifactorial abiotic stress combinations that trigger regulatory responses distinct from those triggered by individual stresses. Traditional single-stress paradigms inadequately capture these complex interactions, limiting crop improvement efforts. Here, we discuss how plants integrate conserved signaling pathways with combination-specific regulatory modules (CSRMs) across multiple regulatory layers to mediate stress tolerance. Using recent findings, including the identification of specific transcription factor complexes that decode unique stress combinations, we highlight how CSRMs coordinate downstream protective pathways such as reactive oxygen species buffering. These insights suggest a multi-layered regulatory logic underlying plant adaptation to combined stresses. Leveraging CSRMs through integrative discovery and engineering approaches offers a promising avenue for developing climate-smart crops with potentially enhanced and stable tolerance under unpredictable field conditions.
SN  - 2667-064X
ER  -