Nutritional status, health literacy, and lifestyle factors associated with health-related quality of life in patients with decompensated cirrhosis: a cross-sectional study.
4 affiliations
- 1Department of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, China.
- 2School of Humanities and Social Sciences, Shanxi Medical University, Taiyuan, China.
- 3Department of Gastroenterology and Hepatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
- 4Shanxi Key Laboratory of Metabolic-Immune Homeostasis and Drug Innovation, Taiyuan, Shanxi, China.
Abstract
Background
Liver cirrhosis is one of the leading causes of liver-related mortality worldwide. The disease typically progresses from an initially asymptomatic, compensated phase to decompensation, which adversely affects patients' health-related quality of life (HRQoL). Identifying the factors that influence HRQoL and implementing effective interventions are essential for improving patient outcomes. Based on the health ecology theory, this study focuses on health literacy and nutritional status, with the aim of enhancing patients' quality of survival through targeted interventions.Methods
A cross-sectional design was employed, using convenience sampling to recruit 202 patients with decompensated cirrhosis. Data collection included demographic information, biochemical indicators, and scores on health literacy, nutritional status, and HRQoL. Using IBM SPSS Statistics version 27, correlation analysis and multiple linear regression were conducted to primarily explore the associations of nutritional status, health literacy, and lifestyle factors with HRQoL.Results
Correlation analysis showed that health literacy, nutritional status, sleep quality, and physical activity were significantly associated with patients' quality of life. Multiple linear regression revealed that nutritional status was independently associated with the HRQoL; notably, the model's explanatory power for HRQoL significantly increased (R Square increment) when health literacy was introduced, indicating practical significance. Furthermore, regression analyses showed that communication ability (B = -0.177, p = 0.007), walking (B = -1.589, p = 0.007), and aerobic exercise (B = -1.739, p = 0.017) as significant predictors of the physical dimension. Poor sleep significantly predicted both dimensions (physical: B = 1.193, p = 0.032; psychological: B = 0.532, p = 0.001), while information acquisition ability (B = -0.028, p = 0.021) specifically predicted the psychological dimension.Conclusion
This study demonstrated that both health literacy and nutritional status were significantly associated with the HRQoL among patients with decompensated cirrhosis. These findings may inform the design of targeted interventions to enhance health literacy and nutritional status, which may be beneficial for promoting self-management and improving clinical outcomes. Furthermore, they support the development of individualized management strategies.
Related
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- Acute Kidney Disease and Clinical Outcomes in Stable Outpatients With Decompensated Cirrhosis: A Prospective Cohort Study
- Clinical and patient-reported predictors of days alive and out of hospital in decompensated cirrhosis
- Plasma Cystatin C as a Marker of Acute-on-Chronic Liver Failure and 28-Day Mortality in Patients With Acutely Decompensated Liver Cirrhosis: A Prospective Observational Study
BibTeX
@article{liu2026nutritional,
title = {{Nutritional status, health literacy, and lifestyle factors associated with health-related quality of life in patients with decompensated cirrhosis: a cross-sectional study.}},
author = {Yan Liu and Shuyue He and Tianyu He and Xingyu Liu and Runzhi Zhang and Xin Liu and Tingjuan Huang and Junjie Ren},
journal = {Frontiers in public health},
year = {2026},
month = oct,
doi = {10.3389/fpubh.2026.1891516},
url = {https://europepmc.org/article/MED/42898274},
note = {CC BY},
}
RIS
TY - JOUR
TI - Nutritional status, health literacy, and lifestyle factors associated with health-related quality of life in patients with decompensated cirrhosis: a cross-sectional study.
AU - Yan Liu
AU - Shuyue He
AU - Tianyu He
AU - Xingyu Liu
AU - Runzhi Zhang
AU - Xin Liu
AU - Tingjuan Huang
AU - Junjie Ren
PY - 2026
DA - 2026/10/05
JO - Frontiers in public health
DO - 10.3389/fpubh.2026.1891516
UR - https://europepmc.org/article/MED/42898274
AB - Background Liver cirrhosis is one of the leading causes of liver-related mortality worldwide. The disease typically progresses from an initially asymptomatic, compensated phase to decompensation, which adversely affects patients' health-related quality of life (HRQoL). Identifying the factors that influence HRQoL and implementing effective interventions are essential for improving patient outcomes. Based on the health ecology theory, this study focuses on health literacy and nutritional status, with the aim of enhancing patients' quality of survival through targeted interventions.Methods A cross-sectional design was employed, using convenience sampling to recruit 202 patients with decompensated cirrhosis. Data collection included demographic information, biochemical indicators, and scores on health literacy, nutritional status, and HRQoL. Using IBM SPSS Statistics version 27, correlation analysis and multiple linear regression were conducted to primarily explore the associations of nutritional status, health literacy, and lifestyle factors with HRQoL.Results Correlation analysis showed that health literacy, nutritional status, sleep quality, and physical activity were significantly associated with patients' quality of life. Multiple linear regression revealed that nutritional status was independently associated with the HRQoL; notably, the model's explanatory power for HRQoL significantly increased (R Square increment) when health literacy was introduced, indicating practical significance. Furthermore, regression analyses showed that communication ability (B = -0.177, p = 0.007), walking (B = -1.589, p = 0.007), and aerobic exercise (B = -1.739, p = 0.017) as significant predictors of the physical dimension. Poor sleep significantly predicted both dimensions (physical: B = 1.193, p = 0.032; psychological: B = 0.532, p = 0.001), while information acquisition ability (B = -0.028, p = 0.021) specifically predicted the psychological dimension.Conclusion This study demonstrated that both health literacy and nutritional status were significantly associated with the HRQoL among patients with decompensated cirrhosis. These findings may inform the design of targeted interventions to enhance health literacy and nutritional status, which may be beneficial for promoting self-management and improving clinical outcomes. Furthermore, they support the development of individualized management strategies.
SN - 2296-2565
ER -