Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells
- 1INSERM -AMU
Abstract
Experience-dependent plasticity is usually attributed to synaptic changes, but neuronal output also depends on changes in intrinsic excitability. Whether intrinsic excitability is persistently modified at the retinal output stage is unknown. Using whole-cell recordings from retinal ganglion cells (RGCs) of juvenile rats, we found that 40-Hz firing produced sustained potentiation of intrinsic excitability in low-input-resistance A-type RGCs and rapid potentiation of intrinsic excitability in high-input-resistance B-type RGCs. In A-type bursting RGCs, long-term potentiation of intrinsic excitability (LTP-IE) required Cav1 calcium channels for its induction. LTP-IE was associated with hyperpolarization of spike threshold and reduction of spike time jitter, due to reduced Kv1 potassium-family channel function. Potentiation also increased the probability that visually-evoked synaptic events triggered action potentials. Patterned firing therefore persistently reconfigures RGC input-output transformation through the Cav1-dependent regulation of Kv1 channels, revealing intrinsic plasticity at the retinal output stage.
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BibTeX
@misc{ramtohul2026gammafrequency,
title = {{Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells}},
author = {P. Ramtohul and L. Molinieres and V. M. Calbiague Garcia and M. L. Musella and F. Abate and A. Aziz and T. David and D. Denis and O. Marre and M. Russier and D. Debanne},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.22.760873},
url = {https://www.biorxiv.org/content/10.64898/2026.10.22.760873v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells
AU - P. Ramtohul
AU - L. Molinieres
AU - V. M. Calbiague Garcia
AU - M. L. Musella
AU - F. Abate
AU - A. Aziz
AU - T. David
AU - D. Denis
AU - O. Marre
AU - M. Russier
AU - D. Debanne
PY - 2026
DA - 2026/10/22
PB - bioRxiv
DO - 10.64898/2026.10.22.760873
UR - https://www.biorxiv.org/content/10.64898/2026.10.22.760873v1
AB - Experience-dependent plasticity is usually attributed to synaptic changes, but neuronal output also depends on changes in intrinsic excitability. Whether intrinsic excitability is persistently modified at the retinal output stage is unknown. Using whole-cell recordings from retinal ganglion cells (RGCs) of juvenile rats, we found that 40-Hz firing produced sustained potentiation of intrinsic excitability in low-input-resistance A-type RGCs and rapid potentiation of intrinsic excitability in high-input-resistance B-type RGCs. In A-type bursting RGCs, long-term potentiation of intrinsic excitability (LTP-IE) required Cav1 calcium channels for its induction. LTP-IE was associated with hyperpolarization of spike threshold and reduction of spike time jitter, due to reduced Kv1 potassium-family channel function. Potentiation also increased the probability that visually-evoked synaptic events triggered action potentials. Patterned firing therefore persistently reconfigures RGC input-output transformation through the Cav1-dependent regulation of Kv1 channels, revealing intrinsic plasticity at the retinal output stage.
ER -