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Peer-reviewedCC BY 4.0Advanced Science

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

  • Xiyu Liu1
  • Wen Zhang1
  • Lunxin Liu2
  • Lan Gui1
  • Yumei Qin1
  • Xiaohui Yang1
  • Longjian Zhang1
  • Chaohua Wang2
  • Jinpeng Hu1
  • Gaoyang Guo1
  • Qing Jiang1
  • Jin Wang3
3 more authors
  • Li Yang1
  • Bo Zhang1
  • Yunbing Wang1
  1. 1National Engineering Research Center for Biomaterials Sichuan University Chengdu Sichuan China
  2. 2Department of Neurosurgery West China Hospital of Sichuan University Chengdu Sichuan China
  3. 3Key Lab of Advanced Technology of Materials of Education Ministry Southwest Jiaotong University Chengdu Sichuan China
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Abstract

Defective endothelial regeneration constitutes a fundamental barrier to durable vascular repair. By integrating single cell RNA‐sequencing data from rat carotid balloon injury with ultrastructural and histological evidence from rabbit stented arteries, we identified mitochondrial disorganization and dysfunction as common features of injured endothelial cells. Guided by these findings, we developed a poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield to couple mitochondrial protection with anticoagulant and immunoregulatory functions for cardiovascular devices. PCGP preserved mitochondrial integrity, restored endothelial metabolic homeostasis, and rescued the regenerative phenotype of endothelial cells under oxidative stress. In rabbit arterial stent models, this intervention reactivated the PI3K/AKT/eNOS‐nitric oxide axis, accelerated functional re‐endothelialization, and markedly suppressed neointimal hyperplasia. Collectively, these findings support restoration of endothelial mitochondrial homeostasis as an important mechanistic axis associated with vascular repair.

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Cite

BibTeXRIS
BibTeX
@article{liu2026restoring,
  title = {{Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants}},
  author = {Xiyu Liu and Wen Zhang and Lunxin Liu and Lan Gui and Yumei Qin and Xiaohui Yang and Longjian Zhang and Chaohua Wang and Jinpeng Hu and Gaoyang Guo and Qing Jiang and Jin Wang and Li Yang and Bo Zhang and Yunbing Wang},
  journal = {Advanced Science},
  year = {2026},
  month = oct,
  doi = {10.1002/advs.77638},
  url = {https://doi.org/10.1002/advs.77638},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants
AU  - Xiyu Liu
AU  - Wen Zhang
AU  - Lunxin Liu
AU  - Lan Gui
AU  - Yumei Qin
AU  - Xiaohui Yang
AU  - Longjian Zhang
AU  - Chaohua Wang
AU  - Jinpeng Hu
AU  - Gaoyang Guo
AU  - Qing Jiang
AU  - Jin Wang
AU  - Li Yang
AU  - Bo Zhang
AU  - Yunbing Wang
PY  - 2026
DA  - 2026/10/25
JO  - Advanced Science
DO  - 10.1002/advs.77638
UR  - https://doi.org/10.1002/advs.77638
AB  - Defective endothelial regeneration constitutes a fundamental barrier to durable vascular repair. By integrating single cell RNA‐sequencing data from rat carotid balloon injury with ultrastructural and histological evidence from rabbit stented arteries, we identified mitochondrial disorganization and dysfunction as common features of injured endothelial cells. Guided by these findings, we developed a poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield to couple mitochondrial protection with anticoagulant and immunoregulatory functions for cardiovascular devices. PCGP preserved mitochondrial integrity, restored endothelial metabolic homeostasis, and rescued the regenerative phenotype of endothelial cells under oxidative stress. In rabbit arterial stent models, this intervention reactivated the PI3K/AKT/eNOS‐nitric oxide axis, accelerated functional re‐endothelialization, and markedly suppressed neointimal hyperplasia. Collectively, these findings support restoration of endothelial mitochondrial homeostasis as an important mechanistic axis associated with vascular repair.
SN  - 2198-3844
ER  -