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PreprintCC BYChemRxiv

Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition

  • Edgar S. Villa
  • James McNeely
  • Hanna R. Warinner
  • John A. Porco
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Abstract

The recently isolated aspercyclicins A and B from Aspergillus sp. LI2020F001 represent a chimeric scaffold derived from crosstalk of two biosynthetic pathways. These natural products display cytotoxicity against cancer cell lines and potently activate immunogenic cell death (ICD). Herein, we report methodology development for biomimetic [4+2] cycloadditions involving an in situ generated isobenzofuran (IBF) leading to the semisyntheses of aspercyclicins A and B from the fungal-derived natural product (+)-geodin.

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Cite

BibTeXRIS
BibTeX
@misc{villa2026semisyntheses,
  title = {{Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition}},
  author = {Edgar S. Villa and James McNeely and Hanna R. Warinner and John A. Porco},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15011019/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011019/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Semisyntheses of Aspercyclicins A and B via Isobenzofuran Cycloaddition
AU  - Edgar S. Villa
AU  - James McNeely
AU  - Hanna R. Warinner
AU  - John A. Porco
PY  - 2026
DA  - 2026/10/25
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15011019/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011019/v1
AB  - The recently isolated aspercyclicins A and B from Aspergillus sp. LI2020F001 represent a chimeric scaffold derived from crosstalk of two biosynthetic pathways. These natural products display cytotoxicity against cancer cell lines and potently activate immunogenic cell death (ICD). Herein, we report methodology development for biomimetic [4+2] cycloadditions involving an in situ generated isobenzofuran (IBF) leading to the semisyntheses of aspercyclicins A and B from the fungal-derived natural product (+)-geodin.
ER  -