Ureteral stricture prediction of occurrence after ureteroscopic lithotripsy.
5 affiliations
- 1Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
- 2Department of Urology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200434, China.
- 3Department of Urology, Kashgar Prefecture Second People's Hospital, Kashgar, Xinjiang Uygur Autonomous Region, 844199, China.
- 4Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. [email protected].
- 5Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. [email protected].
Abstract
Objectives
Ureteral stricture is a significant complication after ureteroscopic lithotripsy (URSL). This study aimed to identify risk factors for post-URSL ureteral stricture and develop a nomogram to predict the timing and probability of stricture occurrence within 1-3 years postoperatively, thereby facilitating individualized follow-up.Methods
We enrolled patients who underwent holmium laser ureteroscopic lithotripsy (URSL) at a single institution between January 1, 2014, and December 31, 2021, and were diagnosed with postoperative ureteral stricture. Baseline characteristics, in-hospital data, surgical indicators, computed tomography data, and laboratory test results of patients with and without stenosis were compared. Cases (n = 70) were patients diagnosed with postoperative ureteral stricture; controls (n = 70) were selected using propensity score matching (age, sex, stone laterality, surgery date) from patients without stricture. T-tests, Pearson's chi-squared, or Fisher's exact tests, LASSO and Cox regression analyses, receiver operating characteristic and Kaplan-Meier curve analyses, and nomogram analysis were used to predict post-URSL ureteral stricture risk factors and timing.Results
Hypertension incidence (P = 0.038), ureteral stent placement time (P = 0.002), stone location (P = 0.04), and hydronephrosis grade (P < 0.001) differed significantly between the groups, and stone impaction were independent risk factors for ureteral stricture. The nomogram showed good discrimination (C-index 0.720) and calibration. Preoperative fever appeared as a protective factor but should be interpreted cautiously due to potential confounding.Conclusion
The nomogram, which based on hydronephrosis grade, ureteral stone location, and incarcerated stones can predict post-URSL ureteral stricture risk and may guide personalized follow-up. External validation is needed before clinical application.
Related
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- Effects of UroVaxom on Urinary Tract Infection After Ureteroscopic Lithotripsy: A Multicenter Prospective Randomized Study
- Current evidence of flexible ureteroscopic laser lithotripsy under local anesthesia: feasibility, safety, and clinical application.
- Intelligent versus flexible negative-pressure aspiration sheath for ureteroscopic lithotripsy: a single-center retrospective study with systematic review and meta-analysis.
BibTeX
@article{gao2026ureteral,
title = {{Ureteral stricture prediction of occurrence after ureteroscopic lithotripsy.}},
author = {Yuchen Gao and Shuai Liu and Jun Luo and Nueraihemaiti Yimingniyizi and Xiao Xu and Hongmin Zhou and Yunze Dong and Bowen Chen and Hao Chen and Yanhua Chen and Xiangcheng Zhan and Ding Liu and Xudong Yao and Tiancheng Xie and Yunfei Xu},
journal = {BMC urology},
year = {2026},
month = jul,
doi = {10.1186/s12894-026-02201-6},
url = {https://europepmc.org/article/MED/42902237},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Ureteral stricture prediction of occurrence after ureteroscopic lithotripsy.
AU - Yuchen Gao
AU - Shuai Liu
AU - Jun Luo
AU - Nueraihemaiti Yimingniyizi
AU - Xiao Xu
AU - Hongmin Zhou
AU - Yunze Dong
AU - Bowen Chen
AU - Hao Chen
AU - Yanhua Chen
AU - Xiangcheng Zhan
AU - Ding Liu
AU - Xudong Yao
AU - Tiancheng Xie
AU - Yunfei Xu
PY - 2026
DA - 2026/07/01
JO - BMC urology
DO - 10.1186/s12894-026-02201-6
UR - https://europepmc.org/article/MED/42902237
AB - Objectives Ureteral stricture is a significant complication after ureteroscopic lithotripsy (URSL). This study aimed to identify risk factors for post-URSL ureteral stricture and develop a nomogram to predict the timing and probability of stricture occurrence within 1-3 years postoperatively, thereby facilitating individualized follow-up.Methods We enrolled patients who underwent holmium laser ureteroscopic lithotripsy (URSL) at a single institution between January 1, 2014, and December 31, 2021, and were diagnosed with postoperative ureteral stricture. Baseline characteristics, in-hospital data, surgical indicators, computed tomography data, and laboratory test results of patients with and without stenosis were compared. Cases (n = 70) were patients diagnosed with postoperative ureteral stricture; controls (n = 70) were selected using propensity score matching (age, sex, stone laterality, surgery date) from patients without stricture. T-tests, Pearson's chi-squared, or Fisher's exact tests, LASSO and Cox regression analyses, receiver operating characteristic and Kaplan-Meier curve analyses, and nomogram analysis were used to predict post-URSL ureteral stricture risk factors and timing.Results Hypertension incidence (P = 0.038), ureteral stent placement time (P = 0.002), stone location (P = 0.04), and hydronephrosis grade (P < 0.001) differed significantly between the groups, and stone impaction were independent risk factors for ureteral stricture. The nomogram showed good discrimination (C-index 0.720) and calibration. Preoperative fever appeared as a protective factor but should be interpreted cautiously due to potential confounding.Conclusion The nomogram, which based on hydronephrosis grade, ureteral stone location, and incarcerated stones can predict post-URSL ureteral stricture risk and may guide personalized follow-up. External validation is needed before clinical application.
SN - 1471-2490
ER -