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Peer-reviewedCC BYNature Communications

Building-block synthesis as a determinant of antibiotic persistence

  • Anaïs Padellec
  • Charlotte Michaux
  • Séverin Ronneau
Open at sourcePDFDOICite

Abstract

Reduced antibiotic target activity is a major driver of antibiotic treatment failure. While this has mostly been linked to the presence of low-energy bacteria, a recent study by Taher and colleagues suggests that reduced building-block synthesis can also promote antibiotic survival during nitrogen starvation — a route distinct from energy limitation.

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Cite

BibTeXRIS
BibTeX
@article{padellec2026buildingblock,
  title = {{Building-block synthesis as a determinant of antibiotic persistence}},
  author = {Anaïs Padellec and Charlotte Michaux and Séverin Ronneau},
  journal = {Nature Communications},
  year = {2026},
  month = sep,
  doi = {10.1038/s41467-026-78277-3},
  url = {https://hal.science/hal-05776713v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Building-block synthesis as a determinant of antibiotic persistence
AU  - Anaïs Padellec
AU  - Charlotte Michaux
AU  - Séverin Ronneau
PY  - 2026
DA  - 2026/09/28
JO  - Nature Communications
DO  - 10.1038/s41467-026-78277-3
UR  - https://hal.science/hal-05776713v1
AB  - Reduced antibiotic target activity is a major driver of antibiotic treatment failure. While this has mostly been linked to the presence of low-energy bacteria, a recent study by Taher and colleagues suggests that reduced building-block synthesis can also promote antibiotic survival during nitrogen starvation — a route distinct from energy limitation.
SN  - 2041-1723
SN  - 2041-1723
ER  -