From childhood to adulthood in chronic intestinal failure: A nationwide study
Abstract
Background and aims: Pediatric chronic intestinal failure (CIF) requires long-term home parenteral nutrition (HPN) to support growth and health. Transitioning to adult care is a critical period, and longterm outcomes remain underexplored. This nationwide study assessed long-term survival, HPN dependence, psychosocial status and characteristics of CIF management in adult patients with pediatric-onset CIF who received HPN during childhood and transition to adulthood. Methods: We conducted a multicenter retrospective study of patients who started HPN for CIF in childhood and transitioned to adult care still receiving HPN between 1995 and 2020. Clinical characteristics and risk factors for survival and HPN dependence were analysed. Results: Ninety-seven patients (46% female) transitioned at a mean age of 19.2 +/- 2.6 years, after HPN began at a median age of 1 year (IQR: 0-8). CIF was caused by short bowel syndrome (60%), motility disorders (27%), and mucosal disease (13%). Management included teduglutide (13%), autologous gastrointestinal reconstruction (6%) and intestinal transplantation (5%). After a median follow-up of 8 years, survival was 91% and HPN dependence 95%. Catheter-related bloodstream infections were the leading cause of death (62%). In multivariate analysis, daily HPN requirement (HR = 5.7, 95%CI: 1.2-26.0, p= 0.03) and intestinal transplantation (HR = 5.9, 95%CI: 1.5-23.0, p= 0.01) were associated with mortality. Teduglutide was the only factor associated with reduced HPN dependence (HR = 10.0, 95%CI: 1.1-88.9, p= 0.04). At last follow-up, 58% of patients were employed or studying, 51% had left the family home, 28% were in a relationship, 20% had psychiatric comorbidities and 14% opioid dependence. Conclusion: Pediatric-onset CIF patients show high survival into adulthood despite persistent HPN dependence. GLP-2 analogues may reduce HPN dependence and improve long-term outcomes. (c) 2026 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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BibTeX
@article{schubert2026from,
title = {{From childhood to adulthood in chronic intestinal failure: A nationwide study}},
author = {Louis Schubert and Cecile Chambrier and Lore Billiauws and Marine Barraud and Florian Poullenot and David Seguy and Nicolas Flori and Ronan Thibault and Stéphane M Schneider and Corinne Bouteloup and Virginie Colomb and Cécile Lambe and Olivier Goulet and Alexandre Nuzzo and Francisca Joly},
journal = {Clinical Nutrition},
year = {2026},
month = oct,
doi = {10.1016/j.clnu.2026.106676},
url = {https://hal.science/hal-05653706v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - From childhood to adulthood in chronic intestinal failure: A nationwide study
AU - Louis Schubert
AU - Cecile Chambrier
AU - Lore Billiauws
AU - Marine Barraud
AU - Florian Poullenot
AU - David Seguy
AU - Nicolas Flori
AU - Ronan Thibault
AU - Stéphane M Schneider
AU - Corinne Bouteloup
AU - Virginie Colomb
AU - Cécile Lambe
AU - Olivier Goulet
AU - Alexandre Nuzzo
AU - Francisca Joly
PY - 2026
DA - 2026/10/23
JO - Clinical Nutrition
DO - 10.1016/j.clnu.2026.106676
UR - https://hal.science/hal-05653706v1
AB - Background and aims: Pediatric chronic intestinal failure (CIF) requires long-term home parenteral nutrition (HPN) to support growth and health. Transitioning to adult care is a critical period, and longterm outcomes remain underexplored. This nationwide study assessed long-term survival, HPN dependence, psychosocial status and characteristics of CIF management in adult patients with pediatric-onset CIF who received HPN during childhood and transition to adulthood. Methods: We conducted a multicenter retrospective study of patients who started HPN for CIF in childhood and transitioned to adult care still receiving HPN between 1995 and 2020. Clinical characteristics and risk factors for survival and HPN dependence were analysed. Results: Ninety-seven patients (46% female) transitioned at a mean age of 19.2 +/- 2.6 years, after HPN began at a median age of 1 year (IQR: 0-8). CIF was caused by short bowel syndrome (60%), motility disorders (27%), and mucosal disease (13%). Management included teduglutide (13%), autologous gastrointestinal reconstruction (6%) and intestinal transplantation (5%). After a median follow-up of 8 years, survival was 91% and HPN dependence 95%. Catheter-related bloodstream infections were the leading cause of death (62%). In multivariate analysis, daily HPN requirement (HR = 5.7, 95%CI: 1.2-26.0, p= 0.03) and intestinal transplantation (HR = 5.9, 95%CI: 1.5-23.0, p= 0.01) were associated with mortality. Teduglutide was the only factor associated with reduced HPN dependence (HR = 10.0, 95%CI: 1.1-88.9, p= 0.04). At last follow-up, 58% of patients were employed or studying, 51% had left the family home, 28% were in a relationship, 20% had psychiatric comorbidities and 14% opioid dependence. Conclusion: Pediatric-onset CIF patients show high survival into adulthood despite persistent HPN dependence. GLP-2 analogues may reduce HPN dependence and improve long-term outcomes. (c) 2026 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
SN - 0261-5614
SN - 1532-1983
ER -