Association between triglyceride-glucose and fibrosis-4 indices and nephrolithiasis: a cross-sectional case-control study.
- 1University of Health Sciences, Prof. Dr. Cemil Taşcıoğlu City Hospital, Department of Endocrinology - Istanbul, Turkey.
- 2University of Health Sciences, Prof. Dr. Cemil Tascıoğlu City Hospital, Department of Urology - Istanbul, Turkey.
Abstract
Objective
Fibrosis-4 (a liver fibrosis index) and triglyceride-glucose (an insulin resistance surrogate) indices may be markers associated with kidney stone risk. The aim of this study was to evaluate the association between triglyceride-glucose and fibrosis-4 indices and the presence of nephrolithiasis in adults.Methods
This retrospective cross-sectional case-control study included 918 adults (785 with nephrolithiasis, 133 controls) evaluated between January 2016 and December 2023. Controls were consecutive patients from the same urology outpatient population who underwent abdominal imaging for non-stone-related urological indications, with no radiological evidence of nephrolithiasis. Triglyceride-glucose and fibrosis-4 indices were calculated using standard formulas. The triglyceride-glucose index was standardized (per 1 SD=0.23 units) prior to multivariable logistic regression including age, sex, and fibrosis-4.Results
Triglyceride-glucose was significantly higher in stone formers (4.87±0.21 vs. 4.64±0.20; p<0.001). In multivariable analysis, triglyceride-glucose independently predicted nephrolithiasis (adjusted OR per 1 SD=3.52; 95%CI 2.48-5.00; p<0.001); male sex was also independently associated. Fibrosis-4 was not independently associated (p=0.809). Triglyceride-glucose area under the curve was 0.779 (95%CI 0.729-0.827), consistent across both sexes (interaction p=0.135).Conclusion
Each 1 SD increase in triglyceride-glucose was associated with a 3.5-fold increase in odds of nephrolithiasis, independent of age, sex, and fibrosis-4. Fibrosis-4 showed no independent utility. Prospective studies are needed to confirm these findings.
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BibTeX
@article{cakır2026association,
title = {{Association between triglyceride-glucose and fibrosis-4 indices and nephrolithiasis: a cross-sectional case-control study.}},
author = {Sezin Doğan Çakır and Mustafa Erkoç and Mine Adaş},
journal = {Revista da Associacao Medica Brasileira (1992)},
year = {2026},
month = oct,
doi = {10.1590/1806-9282.20260298},
url = {https://europepmc.org/article/MED/42879582},
note = {CC BY},
}
RIS
TY - JOUR
TI - Association between triglyceride-glucose and fibrosis-4 indices and nephrolithiasis: a cross-sectional case-control study.
AU - Sezin Doğan Çakır
AU - Mustafa Erkoç
AU - Mine Adaş
PY - 2026
DA - 2026/10/12
JO - Revista da Associacao Medica Brasileira (1992)
DO - 10.1590/1806-9282.20260298
UR - https://europepmc.org/article/MED/42879582
AB - Objective Fibrosis-4 (a liver fibrosis index) and triglyceride-glucose (an insulin resistance surrogate) indices may be markers associated with kidney stone risk. The aim of this study was to evaluate the association between triglyceride-glucose and fibrosis-4 indices and the presence of nephrolithiasis in adults.Methods This retrospective cross-sectional case-control study included 918 adults (785 with nephrolithiasis, 133 controls) evaluated between January 2016 and December 2023. Controls were consecutive patients from the same urology outpatient population who underwent abdominal imaging for non-stone-related urological indications, with no radiological evidence of nephrolithiasis. Triglyceride-glucose and fibrosis-4 indices were calculated using standard formulas. The triglyceride-glucose index was standardized (per 1 SD=0.23 units) prior to multivariable logistic regression including age, sex, and fibrosis-4.Results Triglyceride-glucose was significantly higher in stone formers (4.87±0.21 vs. 4.64±0.20; p<0.001). In multivariable analysis, triglyceride-glucose independently predicted nephrolithiasis (adjusted OR per 1 SD=3.52; 95%CI 2.48-5.00; p<0.001); male sex was also independently associated. Fibrosis-4 was not independently associated (p=0.809). Triglyceride-glucose area under the curve was 0.779 (95%CI 0.729-0.827), consistent across both sexes (interaction p=0.135).Conclusion Each 1 SD increase in triglyceride-glucose was associated with a 3.5-fold increase in odds of nephrolithiasis, independent of age, sex, and fibrosis-4. Fibrosis-4 showed no independent utility. Prospective studies are needed to confirm these findings.
SN - 0104-4230
SN - 1806-9282
ER -