Ferric pyrophosphate in precision iron fortification: mechanistic insights into food-system suitability, bioavailability modulation, and evaluation strategies.
- 1College of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, PR China.
- 2Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, South Korea.
Abstract
Iron is an essential trace nutrient, and iron deficiency remains a major global public health problem. Iron-fortified foods are important vehicles for preventive iron supplementation. Precision iron fortification requires matching iron sources to specific food matrices to balance product quality and fortification efficacy. Ferric pyrophosphate (FePP) shows good food-system stability and gastrointestinal tolerability, but low solubility and limited bioavailability restrict wider application. This review addresses FePP food-system suitability, bioavailability modulation, and evaluation strategies, summarizing physicochemical modification, delivery systems, and absorption-oriented dietary modulation. These approaches improve dispersion and dissolution, control gastrointestinal release and transport, and mediate nutrient effects on Fe³⁺ reduction, complexation, and precipitation. FePP modulation should balance bioavailability and food quality through multilevel evaluation integrating in vitro, cellular, animal, and human studies. Future work should better match modulation technologies to food systems, optimize precision iron fortification, and advance practical FePP application.
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BibTeX
@article{wang2026ferric,
title = {{Ferric pyrophosphate in precision iron fortification: mechanistic insights into food-system suitability, bioavailability modulation, and evaluation strategies.}},
author = {Yuqi Wang and Yunshan Wei and Mengwei Chang and Junhee No and Kunlun Liu},
journal = {Food chemistry: X},
year = {2026},
month = oct,
doi = {10.1016/j.fochx.2026.104600},
url = {https://europepmc.org/article/MED/42904102},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Ferric pyrophosphate in precision iron fortification: mechanistic insights into food-system suitability, bioavailability modulation, and evaluation strategies.
AU - Yuqi Wang
AU - Yunshan Wei
AU - Mengwei Chang
AU - Junhee No
AU - Kunlun Liu
PY - 2026
DA - 2026/10/11
JO - Food chemistry: X
DO - 10.1016/j.fochx.2026.104600
UR - https://europepmc.org/article/MED/42904102
AB - Iron is an essential trace nutrient, and iron deficiency remains a major global public health problem. Iron-fortified foods are important vehicles for preventive iron supplementation. Precision iron fortification requires matching iron sources to specific food matrices to balance product quality and fortification efficacy. Ferric pyrophosphate (FePP) shows good food-system stability and gastrointestinal tolerability, but low solubility and limited bioavailability restrict wider application. This review addresses FePP food-system suitability, bioavailability modulation, and evaluation strategies, summarizing physicochemical modification, delivery systems, and absorption-oriented dietary modulation. These approaches improve dispersion and dissolution, control gastrointestinal release and transport, and mediate nutrient effects on Fe³⁺ reduction, complexation, and precipitation. FePP modulation should balance bioavailability and food quality through multilevel evaluation integrating in vitro, cellular, animal, and human studies. Future work should better match modulation technologies to food systems, optimize precision iron fortification, and advance practical FePP application.
SN - 2590-1575
ER -