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Peer-reviewedCC BY 4.0Alpha Psychiatry

Correlation Analysis of Peripheral Blood Inflammatory Cell Markers With Obesity in Chronic Schizophrenia Patients

  • Lili Wu1
  • Xing Wei2
  • Mengyun Zhang1
  • Chengbing Huang1
  • Wenjie Shi1
  1. 1Department of Psychiatry, Huai’an No.3 People’s Hospital, 223001 Huai’an, Jiangsu, China
  2. 2Department of Psychiatry, Huai’an Xin’an Hospital, 223200 Huai’an, Jiangsu, China
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Abstract

Background:: This study investigated the association between obesity and peripheral blood inflammatory cell markers, namely the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in patients with chronic schizophrenia.

Methods:: A total of 220 hospitalized patients with schizophrenia were enrolled. Obesity was assessed using body mass index (BMI), calculated according to standardized procedures. Participants were categorized into an obesity group (n = 86; BMI ≥28.0 kg/m2) and a non-obesity group (n = 134; BMI 18.5–24.0 kg/m2). Levels of SII, NLR, PLR, neutrophil count, lymphocyte count, and platelet count were measured and compared between the two groups. Correlations between SII, NLR, PLR, and obesity were subsequently analyzed.

Results:: Compared with the non-obesity group, the obesity group exhibited significantly higher SII values, lymphocyte counts, platelet counts, and suicide risk scores. BMI was positively correlated with SII. In addition, NLR was positively correlated with suicide risk scores.

Conclusions:: Patients with chronic schizophrenia and obesity exhibit elevated SII, lymphocyte counts, platelet counts, and suicide risk. SII may serve as a novel peripheral inflammatory marker for predicting obesity in this patient population.

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Cite

BibTeXRIS
BibTeX
@article{wu2026correlation,
  title = {{Correlation Analysis of Peripheral Blood Inflammatory Cell Markers With Obesity in Chronic Schizophrenia Patients}},
  author = {Lili Wu and Xing Wei and Mengyun Zhang and Chengbing Huang and Wenjie Shi},
  journal = {Alpha Psychiatry},
  year = {2026},
  month = sep,
  doi = {10.31083/ap52507},
  url = {https://doi.org/10.31083/ap52507},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Correlation Analysis of Peripheral Blood Inflammatory Cell Markers With Obesity in Chronic Schizophrenia Patients
AU  - Lili Wu
AU  - Xing Wei
AU  - Mengyun Zhang
AU  - Chengbing Huang
AU  - Wenjie Shi
PY  - 2026
DA  - 2026/09/07
JO  - Alpha Psychiatry
DO  - 10.31083/ap52507
UR  - https://doi.org/10.31083/ap52507
AB  - Background:: This study investigated the association between obesity and peripheral blood inflammatory cell markers, namely the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in patients with chronic schizophrenia.  Methods:: A total of 220 hospitalized patients with schizophrenia were enrolled. Obesity was assessed using body mass index (BMI), calculated according to standardized procedures. Participants were categorized into an obesity group (n = 86; BMI ≥28.0 kg/m2) and a non-obesity group (n = 134; BMI 18.5–24.0 kg/m2). Levels of SII, NLR, PLR, neutrophil count, lymphocyte count, and platelet count were measured and compared between the two groups. Correlations between SII, NLR, PLR, and obesity were subsequently analyzed.  Results:: Compared with the non-obesity group, the obesity group exhibited significantly higher SII values, lymphocyte counts, platelet counts, and suicide risk scores. BMI was positively correlated with SII. In addition, NLR was positively correlated with suicide risk scores.  Conclusions:: Patients with chronic schizophrenia and obesity exhibit elevated SII, lymphocyte counts, platelet counts, and suicide risk. SII may serve as a novel peripheral inflammatory marker for predicting obesity in this patient population.
SN  - 2757-8038
ER  -