Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses
Abstract
Syntheses of complex molecular mixtures on the preparative scale are often challenging steps for chemists, which go hand in hand with expensive purification steps. Herein, the preparation and isolation of unsymmetrically substituted porphyrins, obtained from statistical reactions between two benzaldehydes, were investigated. Therefore, a semi-automated modular process was developed to lower the consumable costs, save time, and reduce waste production. We utilized a monomode microwave reactor equipped with an autosampler, and a medium pressure liquid chromatography (MPLC) flash purification device, equipped with a UV/Vis detector and a re-usable glass column packed with SiO 2 . With this method, it was possible to synthesize and purify several statistical porphyrin mixtures, while simultaneously reducing the environmental factor (Efactor) significantly, compared to conventionally performed porphyrin syntheses. Our approach shows that a sustainable investigation of academically relevant low-symmetrical porphyrins can be carried out feasibly, without sacrificing invested time.
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BibTeX
@article{holzel2026addressing,
title = {{Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses}},
author = {Helen Hölzel and Maximilian Muth and Dominik Lungerich and Norbert Jux},
journal = {Chemistry–Methods},
year = {2026},
month = oct,
doi = {10.1002/cmtd.202000055},
url = {https://hal.science/hal-05784004v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses
AU - Helen Hölzel
AU - Maximilian Muth
AU - Dominik Lungerich
AU - Norbert Jux
PY - 2026
DA - 2026/10/07
JO - Chemistry–Methods
DO - 10.1002/cmtd.202000055
UR - https://hal.science/hal-05784004v1
AB - Syntheses of complex molecular mixtures on the preparative scale are often challenging steps for chemists, which go hand in hand with expensive purification steps. Herein, the preparation and isolation of unsymmetrically substituted porphyrins, obtained from statistical reactions between two benzaldehydes, were investigated. Therefore, a semi-automated modular process was developed to lower the consumable costs, save time, and reduce waste production. We utilized a monomode microwave reactor equipped with an autosampler, and a medium pressure liquid chromatography (MPLC) flash purification device, equipped with a UV/Vis detector and a re-usable glass column packed with SiO 2 . With this method, it was possible to synthesize and purify several statistical porphyrin mixtures, while simultaneously reducing the environmental factor (Efactor) significantly, compared to conventionally performed porphyrin syntheses. Our approach shows that a sustainable investigation of academically relevant low-symmetrical porphyrins can be carried out feasibly, without sacrificing invested time.
SN - 2628-9725
ER -