Mechanochemical synthesis using hypervalent iodine reagents
Abstract
Mechanochemical activation offers a powerful means of expanding the reactivity of hypervalent iodine reagents while advancing solvent-free synthetic methodologies. This review surveys the evolution of iodine(III) and iodine(V) chemistry in the solid state, from foundational solvent-free oxidations to mechanochemical approaches that enable efficient heterocycle construction, C–H functionalization, cascade dioxygenation, fluoroiodane-mediated fluorocyclization, and redox-initiated polymerization. Mechanical energy alters aggregation, enhances reagent–substrate contact, and promotes transformation pathways not readily accessible in solution. These developments showcase the distinctive advantages of mechanochemical hypervalent iodine chemistry and its growing impact on sustainable synthetic methodology development.
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BibTeX
@article{amri2026mechanochemical,
title = {{Mechanochemical synthesis using hypervalent iodine reagents}},
author = {Nasser Amri},
journal = {Beilstein Journal of Organic Chemistry},
year = {2026},
month = oct,
doi = {10.3762/bjoc.22.115},
url = {https://www.beilstein-journals.org/bjoc/articles/22/115},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Mechanochemical synthesis using hypervalent iodine reagents
AU - Nasser Amri
PY - 2026
DA - 2026/10/13
JO - Beilstein Journal of Organic Chemistry
DO - 10.3762/bjoc.22.115
UR - https://www.beilstein-journals.org/bjoc/articles/22/115
AB - Mechanochemical activation offers a powerful means of expanding the reactivity of hypervalent iodine reagents while advancing solvent-free synthetic methodologies. This review surveys the evolution of iodine(III) and iodine(V) chemistry in the solid state, from foundational solvent-free oxidations to mechanochemical approaches that enable efficient heterocycle construction, C–H functionalization, cascade dioxygenation, fluoroiodane-mediated fluorocyclization, and redox-initiated polymerization. Mechanical energy alters aggregation, enhances reagent–substrate contact, and promotes transformation pathways not readily accessible in solution. These developments showcase the distinctive advantages of mechanochemical hypervalent iodine chemistry and its growing impact on sustainable synthetic methodology development.
SN - 1860-5397
ER -