Microneedling Combined With Biomimetic Peptides for Burn Scar Improvement: A Prospective Study.
12 affiliations
- 1From the Veyrith Advanced Aesthetics, Mexico City, Mexico.
- 2Oral and Maxillofacial Surgery Specialist, Private Practice, Cairo, Egypt.
- 3DRUBIO Medicina Estética y Control de Peso, México.
- 4Élevé Clinic, Kirei University, México.
- 5Private practice, Mexico City, Mexico.
- 6Blux Aesthetic Center, Mexico.
- 7Nuboskin Clinic, Estado de México, México.
- 8Harmonic Face Clinic/COMPECC, Estado de México, México.
- 9Harmonic Face Clinic, Ciudad López Mateos, Mexico.
- 10Clinique Mediluxe, Montreal, Canada.
- 11Private Practice, Copenhagen, Denmark.
- 12Eye Department, Roskilde University Hospital, Roskilde, Denmark.
Abstract
Background
Hypertrophic scarring commonly follows burn injury, resulting from persistent inflammation, abnormal fibroblast activity, and excessive extracellular matrix deposition, leading to functional limitation and aesthetic impairment. Despite multimodal management, outcomes remain variable. Biomimetic peptides can modulate cellular pathways involved in tissue repair, whereas microneedling enhances transdermal delivery and stimulates dermal remodeling.Methods
This prospective, single-arm, interventional, before-and-after clinical study evaluated patients with hypertrophic burn scars treated with microneedling-assisted delivery of biomimetic peptides. Participants underwent 5 treatment sessions at 12-week intervals, followed by a final follow-up assessment 12 weeks after the last session (week 60). Scar characteristics were assessed at baseline and during follow-up using validated instruments, including the Vancouver Scar Scale and the Patient and Observer Scar Assessment Scale. Scar-related symptoms and functional limitation were also recorded. Safety was monitored through prospective reporting of adverse events. Pre- and posttreatment outcomes were compared within subjects.Results
Following therapy, improvement was observed across multiple scar domains, including pigmentation, pliability, thickness, and vascularity, reflected by reductions in Vancouver Scar Scale and Patient and Observer Scar Assessment Scale observer scores. Patient-reported outcomes showed parallel improvements in discomfort, pruritus, and perceived stiffness, accompanied by gains in functional mobility. No serious adverse events or treatment discontinuations occurred.Conclusions
Microneedling-assisted biomimetic peptide therapy was associated with meaningful improvements in scar appearance and patient-reported function in hypertrophic burn scars. This minimally invasive approach may complement comprehensive scar rehabilitation. Controlled studies are needed to confirm efficacy and refine protocols.
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BibTeX
@article{crespo2026microneedling,
title = {{Microneedling Combined With Biomimetic Peptides for Burn Scar Improvement: A Prospective Study.}},
author = {Francisco Hernández Gómez Crespo and Noury Adel and Miguel Rubio Henaine and Karen Dominguez Marchan and Francisco Llano and Diego Ivan Briseno Torres and Jesus Alejandro Lopez-Lara and Gabriela Yareli Zavala Resendiz and Ricardo Villaseñor Domínguez and Cintia Peña Pandura and Alexander Nguyen and Jesper Thulesen and Ida Vega Thulesen},
journal = {Plastic and reconstructive surgery. Global open},
year = {2026},
month = oct,
doi = {10.1097/gox.0000000000008184},
url = {https://europepmc.org/article/MED/42903302},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Microneedling Combined With Biomimetic Peptides for Burn Scar Improvement: A Prospective Study.
AU - Francisco Hernández Gómez Crespo
AU - Noury Adel
AU - Miguel Rubio Henaine
AU - Karen Dominguez Marchan
AU - Francisco Llano
AU - Diego Ivan Briseno Torres
AU - Jesus Alejandro Lopez-Lara
AU - Gabriela Yareli Zavala Resendiz
AU - Ricardo Villaseñor Domínguez
AU - Cintia Peña Pandura
AU - Alexander Nguyen
AU - Jesper Thulesen
AU - Ida Vega Thulesen
PY - 2026
DA - 2026/10/20
JO - Plastic and reconstructive surgery. Global open
DO - 10.1097/gox.0000000000008184
UR - https://europepmc.org/article/MED/42903302
AB - Background Hypertrophic scarring commonly follows burn injury, resulting from persistent inflammation, abnormal fibroblast activity, and excessive extracellular matrix deposition, leading to functional limitation and aesthetic impairment. Despite multimodal management, outcomes remain variable. Biomimetic peptides can modulate cellular pathways involved in tissue repair, whereas microneedling enhances transdermal delivery and stimulates dermal remodeling.Methods This prospective, single-arm, interventional, before-and-after clinical study evaluated patients with hypertrophic burn scars treated with microneedling-assisted delivery of biomimetic peptides. Participants underwent 5 treatment sessions at 12-week intervals, followed by a final follow-up assessment 12 weeks after the last session (week 60). Scar characteristics were assessed at baseline and during follow-up using validated instruments, including the Vancouver Scar Scale and the Patient and Observer Scar Assessment Scale. Scar-related symptoms and functional limitation were also recorded. Safety was monitored through prospective reporting of adverse events. Pre- and posttreatment outcomes were compared within subjects.Results Following therapy, improvement was observed across multiple scar domains, including pigmentation, pliability, thickness, and vascularity, reflected by reductions in Vancouver Scar Scale and Patient and Observer Scar Assessment Scale observer scores. Patient-reported outcomes showed parallel improvements in discomfort, pruritus, and perceived stiffness, accompanied by gains in functional mobility. No serious adverse events or treatment discontinuations occurred.Conclusions Microneedling-assisted biomimetic peptide therapy was associated with meaningful improvements in scar appearance and patient-reported function in hypertrophic burn scars. This minimally invasive approach may complement comprehensive scar rehabilitation. Controlled studies are needed to confirm efficacy and refine protocols.
SN - 2169-7574
ER -