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Peer-reviewedCC BY-NCScience Advances

In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations

  • Yi Lan1,2,3
  • Guoyong Yan1,2
  • Hao Wang1,4
  • Kexin Gao5
  • Yuxuan Lin2
  • Tulika Bhardwaj3
  • Chao Lian4
  • Bing-Zheng Wu6
  • Jiying Li2
  • Casey R. J. Hubert3
  • Jin Sun5
  • Pei-Yuan Qian1,2
6 affiliations
  1. 1Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
  2. 2Department of Ocean Science and Otto Poon Centre for Climate Resilience and Sustainability, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
  3. 3Geomicrobiology Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
  4. 4Centre of Deep-Sea Research, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
  5. 5Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.
  6. 6College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China.
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Abstract

and its sulfur-oxidizing symbionts during sulfide shortage via in situ transplant experiments at the Haima cold seep. Transplanting clams to sulfide-depleted conditions (moderate at HM-3 and severe at HM-2) revealed distinct response patterns of host-symbiont interaction. Symbionts may mitigate sulfide loss by shifting from sulfide oxidation to thiosulfate oxidation, supported by thiosulfate generated through host sulfide detoxification pathways. Notably, symbiont abundance remained stable under moderate sulfide shortage (HM-3), accompanied by down-regulation of host endosomal maturation and fusion with lysosomes, potentially limiting symbiont turnover. Conversely, severe sulfide shortage (HM-2) was associated with up-regulation of lysosomal pathways and lower symbiont abundance. These results demonstrate tiered molecular adaptations-metabolic flexibility and shifts in symbiont dynamics-enabling holobiont resilience to spatially heterogeneous sulfide availability in deep-sea seeps, supporting ecosystem stability.

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Cite

BibTeXRIS
BibTeX
@article{lan2026situ,
  title = {{In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations}},
  author = {Yi Lan and Guoyong Yan and Hao Wang and Kexin Gao and Yuxuan Lin and Tulika Bhardwaj and Chao Lian and Bing-Zheng Wu and Jiying Li and Casey R. J. Hubert and Jin Sun and Pei-Yuan Qian},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aed8728},
  url = {https://www.science.org/doi/10.1126/sciadv.aed8728},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations
AU  - Yi Lan
AU  - Guoyong Yan
AU  - Hao Wang
AU  - Kexin Gao
AU  - Yuxuan Lin
AU  - Tulika Bhardwaj
AU  - Chao Lian
AU  - Bing-Zheng Wu
AU  - Jiying Li
AU  - Casey R. J. Hubert
AU  - Jin Sun
AU  - Pei-Yuan Qian
PY  - 2026
DA  - 2026/10/02
JO  - Science Advances
DO  - 10.1126/sciadv.aed8728
UR  - https://www.science.org/doi/10.1126/sciadv.aed8728
AB  - and its sulfur-oxidizing symbionts during sulfide shortage via in situ transplant experiments at the Haima cold seep. Transplanting clams to sulfide-depleted conditions (moderate at HM-3 and severe at HM-2) revealed distinct response patterns of host-symbiont interaction. Symbionts may mitigate sulfide loss by shifting from sulfide oxidation to thiosulfate oxidation, supported by thiosulfate generated through host sulfide detoxification pathways. Notably, symbiont abundance remained stable under moderate sulfide shortage (HM-3), accompanied by down-regulation of host endosomal maturation and fusion with lysosomes, potentially limiting symbiont turnover. Conversely, severe sulfide shortage (HM-2) was associated with up-regulation of lysosomal pathways and lower symbiont abundance. These results demonstrate tiered molecular adaptations-metabolic flexibility and shifts in symbiont dynamics-enabling holobiont resilience to spatially heterogeneous sulfide availability in deep-sea seeps, supporting ecosystem stability.
SN  - 2375-2548
ER  -