Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 37 min ago
Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Tenascin X and Tenascin C Serum Levels in Relation to Age and Cardiometabolic Risk Parameters

  • Sabina Baumgartner-Parzer1
  • Konstantin Fuhrberg1
  • Christine Wagenlechner2
  • Franziska Schnait1
  • Nina Schmid1
  • Michaela Bayerle-Eder1
  • Gabriele Grimm3
  • Greisa Vila1
  • Marie Helene Schernthaner-Reiter1
  1. 1Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
  2. 2Institute for Medical Statistics, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
  3. 3Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
Read full textPDFDOICite

Abstract

Tenascin C (TNC) and tenascin X (TNX) are extracellular matrix glycoproteins in the same family but with reportedly distinct functions: TNC is acutely up-regulated during tissue damage, whereas TNX maintains structural connective tissue stability. Recently, recurring pathogenic variants in the TNX gene (TNXB) were linked to Ehlers–Danlos syndrome in patients with congenital adrenal hyperplasia, yet the regulation and clinical function of TNX remain poorly understood. In this retrospective cohort study, serum TNX and TNC were measured by ELISA in 274 patients with prevalent cardiovascular risk factors. In bivariate analyses, TNX levels correlated negatively with age and cardiometabolic risk parameters (blood pressure, glucose) and positively with kidney function; in multivariable regression, TNX was independently associated with age, sex, and height, whereas the associations with cardiometabolic parameters were no longer significant. TNX levels remained unchanged following acute glucocorticoid administration. TNC levels correlated negatively with age and glycated hemoglobin and positively with kidney function in bivariate analyses. These findings support distinct but overlapping roles for TNX and TNC in connective tissue function and extend current knowledge, suggesting both proteins as candidate systemic biomarkers for aging. A further investigation of TNX and TNC in a clinical context could reveal new mechanisms for the detection or prevention of cardiometabolic disease.

Related

  1. Association of MALAT1 and TUG1 transcript levels and cardiometabolic diseases according to cholesterol saturated fat index
    Niloufar Rasaei, Mahsa Samadi, Farideh Shiraseb +8
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textGenetics & genomicsCrossref
  2. Serum relaxin and beta hCG levels in pregnant women with prior recurrent pregnancy loss and composite adverse pregnancy outcomes
    George Uchenna Eleje, Emmanuel Onyebuchi Ugwu, Christian Ejike Onah +40
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textImmunologyCrossref
  3. The Predictive Value of Serum Erythropoietin Levels Measured at Diagnosis in Patients With Myelodysplastic Syndromes
    Dominic Culligan, Adele Taylor, Alexandra Smith +17
    eJHaemPeer-reviewedCC BYGeneral biologyHAL
  4. Targeted lipidomics showed altered serum phosphatidylcholine levels in fearful dogs
    Luigi Sacchettino, Michele Costanzo, Sabrina Bianco +6
    PLOS OnePeer-reviewedCC BY 4.0Full textZoology & animal behaviourPLOS
  5. Quality Perception of Interspecific Hybrid Red Wine in Relation to Anthocyanin Profile and Color Parameters
    Catherine Dadmun, Natalia Quijada-Morin, Régis D Gougeon +1
    American Journal of Enology and ViticulturePeer-reviewedCC BY 4.0Full textGeneral biologyNutritionHAL

Cite

BibTeXRIS
BibTeX
@article{baumgartnerparzer2026tenascin,
  title = {{Tenascin X and Tenascin C Serum Levels in Relation to Age and Cardiometabolic Risk Parameters}},
  author = {Sabina Baumgartner-Parzer and Konstantin Fuhrberg and Christine Wagenlechner and Franziska Schnait and Nina Schmid and Michaela Bayerle-Eder and Gabriele Grimm and Greisa Vila and Marie Helene Schernthaner-Reiter},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27209180},
  url = {https://www.mdpi.com/1422-0067/27/20/9180},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Tenascin X and Tenascin C Serum Levels in Relation to Age and Cardiometabolic Risk Parameters
AU  - Sabina Baumgartner-Parzer
AU  - Konstantin Fuhrberg
AU  - Christine Wagenlechner
AU  - Franziska Schnait
AU  - Nina Schmid
AU  - Michaela Bayerle-Eder
AU  - Gabriele Grimm
AU  - Greisa Vila
AU  - Marie Helene Schernthaner-Reiter
PY  - 2026
DA  - 2026/10/16
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27209180
UR  - https://www.mdpi.com/1422-0067/27/20/9180
AB  - Tenascin C (TNC) and tenascin X (TNX) are extracellular matrix glycoproteins in the same family but with reportedly distinct functions: TNC is acutely up-regulated during tissue damage, whereas TNX maintains structural connective tissue stability. Recently, recurring pathogenic variants in the TNX gene (TNXB) were linked to Ehlers–Danlos syndrome in patients with congenital adrenal hyperplasia, yet the regulation and clinical function of TNX remain poorly understood. In this retrospective cohort study, serum TNX and TNC were measured by ELISA in 274 patients with prevalent cardiovascular risk factors. In bivariate analyses, TNX levels correlated negatively with age and cardiometabolic risk parameters (blood pressure, glucose) and positively with kidney function; in multivariable regression, TNX was independently associated with age, sex, and height, whereas the associations with cardiometabolic parameters were no longer significant. TNX levels remained unchanged following acute glucocorticoid administration. TNC levels correlated negatively with age and glycated hemoglobin and positively with kidney function in bivariate analyses. These findings support distinct but overlapping roles for TNX and TNC in connective tissue function and extend current knowledge, suggesting both proteins as candidate systemic biomarkers for aging. A further investigation of TNX and TNC in a clinical context could reveal new mechanisms for the detection or prevention of cardiometabolic disease.
SN  - 1422-0067
ER  -