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Peer-reviewedCC BY-NCJournal of orthopaedic case reports

Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report.

  • Jean G Louka1
  • Eric Kholodovsky2
  • Julien Montreuil2,3
  • Andrew E Rosenberg4
  • Taha Aksoy2,3
  • H Thomas Temple2,3
4 affiliations
  1. 1Montefiore Einstein, Department of Orthopaedic Surgery, Bronx, New York, USA.
  2. 2Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
  3. 3Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, USA.
  4. 4Department of Pathology and Laboratory Medicine, University of Miami Hospital, Miami, Florida, USA.
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Abstract

Unicameral bone cysts (UBCs) are benign, fluid-filled lesions most commonly affecting the proximal humerus in children. Malignant transformation of a histologically confirmed UBC is extraordinarily rare, with only isolated cases reported in the literature. A 12-year-old girl developed high-grade telangiectatic osteosarcoma of the left proximal humerus 18 months after curettage and injection of a bone substitute for a biopsy-proven UBC. She presented with new-onset shoulder pain, and further imaging and biopsy confirmed telangiectatic osteosarcoma. She underwent neoadjuvant chemotherapy followed by wide resection and alloprosthetic hemiarthroplasty reconstruction. This rare case highlights that new or recurrent symptoms after treatment of benign bone tumors warrant immediate re-evaluation, as malignant transformation, though rare, can occur.

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Cite

BibTeXRIS
BibTeX
@article{louka2026telangiectatic,
  title = {{Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report.}},
  author = {Jean G Louka and Eric Kholodovsky and Julien Montreuil and Andrew E Rosenberg and Taha Aksoy and H Thomas Temple},
  journal = {Journal of orthopaedic case reports},
  year = {2026},
  month = nov,
  doi = {10.13107/jocr.2026.v16.i11.8372},
  url = {https://europepmc.org/article/MED/42997095},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Telangiectatic Osteosarcoma Arising in a Treated Unicameral Bone Cyst of the Proximal Humerus: A Case Report.
AU  - Jean G Louka
AU  - Eric Kholodovsky
AU  - Julien Montreuil
AU  - Andrew E Rosenberg
AU  - Taha Aksoy
AU  - H Thomas Temple
PY  - 2026
DA  - 2026/11/01
JO  - Journal of orthopaedic case reports
DO  - 10.13107/jocr.2026.v16.i11.8372
UR  - https://europepmc.org/article/MED/42997095
AB  - Unicameral bone cysts (UBCs) are benign, fluid-filled lesions most commonly affecting the proximal humerus in children. Malignant transformation of a histologically confirmed UBC is extraordinarily rare, with only isolated cases reported in the literature. A 12-year-old girl developed high-grade telangiectatic osteosarcoma of the left proximal humerus 18 months after curettage and injection of a bone substitute for a biopsy-proven UBC. She presented with new-onset shoulder pain, and further imaging and biopsy confirmed telangiectatic osteosarcoma. She underwent neoadjuvant chemotherapy followed by wide resection and alloprosthetic hemiarthroplasty reconstruction. This rare case highlights that new or recurrent symptoms after treatment of benign bone tumors warrant immediate re-evaluation, as malignant transformation, though rare, can occur.
SN  - 2250-0685
SN  - 2321-3817
ER  -