Prevalence and Clinical Significance of Gastric-Type Mucosal Lesions in Non-Ampullary Duodenal Epithelial Tumors Based on Mucin Phenotype.
4 affiliations
- 1Department of Gastroenterology Shizuoka General Hospital Shizuoka Japan.
- 2Biostatistics and Health Data Science Graduate School of Medical Science Nagoya City University Aichi Japan.
- 3Department of Pathology Shizuoka General Hospital Shizuoka Japan.
- 4Department of General Internal Medicine 2 Kawasaki Medical School Okayama Japan.
Abstract
Objectives
Non-ampullary duodenal epithelial tumors differ in clinicopathological features according to mucin phenotype. Gastric-type tumors have distinct biological features; however, their associated mucosal background remains unclear. In this study, gastric foveolar metaplasia, gastric heterotopia, and Brunner's gland hyperplasia were collectively referred to as gastric-type mucosal lesions (G-MLs). We aimed to assess their prevalence and associations with mucin phenotype and clinicopathological factors.Methods
We retrospectively analyzed the data of 130 patients with 130 resected non-ampullary duodenal epithelial tumors at a single center. Tumors were classified according to mucin phenotype. The prevalence of concomitant G-MLs and associated factors was evaluated. Exploratory Firth-penalized logistic regression analysis was used to assess the association between gastric-type tumors and G-ML presence.Results
Concomitant G-MLs were identified in 44 patients (33.8%). Their prevalence was higher in gastric-type tumors (13/16; 81.3%) than in gastric-intestinal-type tumors (10/37; 27.0%) and intestinal-type tumors (21/77; 27.3%). G-MLs were associated with mild endoscopic gastric mucosal atrophy and smoking status and were inversely associated with current Helicobacter pylori infection. In the exploratory fully adjusted model, gastric-type tumors remained positively associated with the presence of G-MLs (adjusted odds ratio, 7.00; 95% confidence interval, 1.98-30.95; p = 0.002).Conclusions
G-MLs were present in approximately one-third of patients and were most frequent in gastric-type tumors. These findings indicate an association between G-MLs and gastric-type tumors; however, the cross-sectional design does not allow inference of a biological relationship.Trial registration
N/A.
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BibTeX
@article{ohno2026prevalence,
title = {{Prevalence and Clinical Significance of Gastric-Type Mucosal Lesions in Non-Ampullary Duodenal Epithelial Tumors Based on Mucin Phenotype.}},
author = {Kazuya Ohno and Eiji Nakatani and Takafumi Kurokami and Asami Kawai and Masanori Matsuda and Yuichi Masui and Tatsunori Satoh and Taiyo Hirata and Shodai Takeda and Yoshihiro Uehara and Kodai Baba and Yuka Ozaki and Tomoki Hikichi and Haruna Takahashi and Koki Sakaguchi and Kazuhito Honda and Tomomi Maeda and Moeri Hotta and Naofumi Nakamura and Makoto Suzuki and Ken Haruma},
journal = {DEN open},
year = {2026},
month = oct,
doi = {10.1002/deo2.70443},
url = {https://europepmc.org/article/MED/42948259},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence and Clinical Significance of Gastric-Type Mucosal Lesions in Non-Ampullary Duodenal Epithelial Tumors Based on Mucin Phenotype.
AU - Kazuya Ohno
AU - Eiji Nakatani
AU - Takafumi Kurokami
AU - Asami Kawai
AU - Masanori Matsuda
AU - Yuichi Masui
AU - Tatsunori Satoh
AU - Taiyo Hirata
AU - Shodai Takeda
AU - Yoshihiro Uehara
AU - Kodai Baba
AU - Yuka Ozaki
AU - Tomoki Hikichi
AU - Haruna Takahashi
AU - Koki Sakaguchi
AU - Kazuhito Honda
AU - Tomomi Maeda
AU - Moeri Hotta
AU - Naofumi Nakamura
AU - Makoto Suzuki
AU - Ken Haruma
PY - 2026
DA - 2026/10/26
JO - DEN open
DO - 10.1002/deo2.70443
UR - https://europepmc.org/article/MED/42948259
AB - Objectives Non-ampullary duodenal epithelial tumors differ in clinicopathological features according to mucin phenotype. Gastric-type tumors have distinct biological features; however, their associated mucosal background remains unclear. In this study, gastric foveolar metaplasia, gastric heterotopia, and Brunner's gland hyperplasia were collectively referred to as gastric-type mucosal lesions (G-MLs). We aimed to assess their prevalence and associations with mucin phenotype and clinicopathological factors.Methods We retrospectively analyzed the data of 130 patients with 130 resected non-ampullary duodenal epithelial tumors at a single center. Tumors were classified according to mucin phenotype. The prevalence of concomitant G-MLs and associated factors was evaluated. Exploratory Firth-penalized logistic regression analysis was used to assess the association between gastric-type tumors and G-ML presence.Results Concomitant G-MLs were identified in 44 patients (33.8%). Their prevalence was higher in gastric-type tumors (13/16; 81.3%) than in gastric-intestinal-type tumors (10/37; 27.0%) and intestinal-type tumors (21/77; 27.3%). G-MLs were associated with mild endoscopic gastric mucosal atrophy and smoking status and were inversely associated with current Helicobacter pylori infection. In the exploratory fully adjusted model, gastric-type tumors remained positively associated with the presence of G-MLs (adjusted odds ratio, 7.00; 95% confidence interval, 1.98-30.95; p = 0.002).Conclusions G-MLs were present in approximately one-third of patients and were most frequent in gastric-type tumors. These findings indicate an association between G-MLs and gastric-type tumors; however, the cross-sectional design does not allow inference of a biological relationship.Trial registration N/A.
SN - 2692-4609
ER -