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Peer-reviewedCC BY 4.0Frontiers in Endocrinology

Assessment of changes in quality of life after thyroid surgery in older adults. A prospective study

  • Vittorio Falco1
  • Yanina Morosán Allo1
  • Carina Parisi1
  • Cristina Faingold1
  • Gabriel Fideleff2
  • Maximiliano Lo Tartaro3
  • Tomas Meroño4
  • Torquil Watt5
  • Victor Brun Boesen6
  • Ulla Feldt-Rassmussen7,8
  • Gabriela Brenta1
8 affiliations
  1. 1Department of Medical Endocrinology and Metabolism, Unidad Asistencial Dr. César Milstein
  2. 2Department of Biochemistry, Unidad Asistencial Dr. César Milstein
  3. 3Department of Surgery, Unidad Asistencial Dr. César Milstein
  4. 4Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Nutrition and Food Safety Research Institute (INSA-UB), Faculty of Pharmacy and Food Sciences, University of Barcelona
  5. 5Medical and Translational Science, Novo Nordisk
  6. 6Department of Medicine, Zealand University Hospital
  7. 7Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital
  8. 8Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University
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Abstract

Objective: Referral of older adults with thyroid nodular disease to surgery remains a challenge. We measured the impact of thyroid surgery on thyroid-related quality of life among older adults with nodular thyroid disease to aid decision-making.

Methods: In this prospective study, all patients aged> 60 years undergoing thyroid surgery for nodular thyroid disease completed the short-form Thyroid-Related Quality of Life (QoL) Patient-Reported Outcome (ThyPRO-39), expanded to include the full 85-item ThyPRO scales for physical thyroid symptoms, at admission and 6–12 months after surgery. Thyroid function testing, histological reports, and surgery extension were recorded. Wilcoxon tests were corrected for multiple comparisons, and linear mixed models were employed in the statistical analyses.

Results: Of 88 patients (81% female, age 71 ± 6 years), 31 had malignant and 57 benign nodules. After surgery, patients showed a significant improvement (p < 0.01) in 10 of the 13 ThyPRO scales, four physical symptoms, two mental well-being scales (Anxiety and emotional susceptibility), all QoL Impairment scales, and the ThyPRO-39 Composite scale (30 ± 17 vs. 21 ± 13, p < 0.01). Improvements in physical symptoms and QoL impairment scales were observed primarily in the benign nodules group ( p for interaction < 0.05). Although both lobectomy and total thyroidectomy improved QoL, lobectomized patients maintained T3 concentrations comparable to baseline.

Conclusion: Surgery improved most of the ThyPRO domains in older adults with nodular disease. Furthermore, goiter-related symptoms that impaired daily life and overall QoL improved primarily in benign disease. ThyPRO scores improved after both hemithyroidectomy and total thyroidectomy.

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Cite

BibTeXRIS
BibTeX
@article{falco2026assessment,
  title = {{Assessment of changes in quality of life after thyroid surgery in older adults. A prospective study}},
  author = {Vittorio Falco and Yanina Morosán Allo and Carina Parisi and Cristina Faingold and Gabriel Fideleff and Maximiliano Lo Tartaro and Tomas Meroño and Torquil Watt and Victor Brun Boesen and Ulla Feldt-Rassmussen and Gabriela Brenta},
  journal = {Frontiers in Endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1967551},
  url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1967551/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Assessment of changes in quality of life after thyroid surgery in older adults. A prospective study
AU  - Vittorio Falco
AU  - Yanina Morosán Allo
AU  - Carina Parisi
AU  - Cristina Faingold
AU  - Gabriel Fideleff
AU  - Maximiliano Lo Tartaro
AU  - Tomas Meroño
AU  - Torquil Watt
AU  - Victor Brun Boesen
AU  - Ulla Feldt-Rassmussen
AU  - Gabriela Brenta
PY  - 2026
DA  - 2026/10/14
JO  - Frontiers in Endocrinology
DO  - 10.3389/fendo.2026.1967551
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2026.1967551/full
AB  - Objective: Referral of older adults with thyroid nodular disease to surgery remains a challenge. We measured the impact of thyroid surgery on thyroid-related quality of life among older adults with nodular thyroid disease to aid decision-making.  Methods: In this prospective study, all patients aged> 60 years undergoing thyroid surgery for nodular thyroid disease completed the short-form Thyroid-Related Quality of Life (QoL) Patient-Reported Outcome (ThyPRO-39), expanded to include the full 85-item ThyPRO scales for physical thyroid symptoms, at admission and 6–12 months after surgery. Thyroid function testing, histological reports, and surgery extension were recorded. Wilcoxon tests were corrected for multiple comparisons, and linear mixed models were employed in the statistical analyses.  Results: Of 88 patients (81% female, age 71 ± 6 years), 31 had malignant and 57 benign nodules. After surgery, patients showed a significant improvement (p < 0.01) in 10 of the 13 ThyPRO scales, four physical symptoms, two mental well-being scales (Anxiety and emotional susceptibility), all QoL Impairment scales, and the ThyPRO-39 Composite scale (30 ± 17 vs. 21 ± 13, p < 0.01). Improvements in physical symptoms and QoL impairment scales were observed primarily in the benign nodules group ( p for interaction < 0.05). Although both lobectomy and total thyroidectomy improved QoL, lobectomized patients maintained T3 concentrations comparable to baseline.  Conclusion: Surgery improved most of the ThyPRO domains in older adults with nodular disease. Furthermore, goiter-related symptoms that impaired daily life and overall QoL improved primarily in benign disease. ThyPRO scores improved after both hemithyroidectomy and total thyroidectomy.
SN  - 1664-2392
ER  -