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Peer-reviewedCC BYPRX Life

Roadmap for Condensates in Cell Biology

  • Dilimulati Aierken1
  • Sebastian Aland2,3,4,5
  • Stefano Bo6
  • Steven Boeynaems7,8
  • Danfeng Cai9,10,11
  • Serena Carra12
  • Lindsay B. Case13
  • Hue Sun Chan14
  • Jorge R. Espinosa15,16,17
  • Trevor GrandPre18,19,20
  • Alexander Y. Grosberg21
  • Ivar S. Haugerud22
29 more authors
  • William M. Jacobs1
  • Jerelle A. Joseph1
  • Frank Jülicher23
  • Kurt Kremer24
  • Guido L. A. Kusters25
  • Liedewij Laan26
  • Keren Lasker27
  • Kathrin S. Laxhuber23
  • Hyun O. Lee14
  • Kathy F. Liu28
  • Dimple Notani29,30
  • Yicheng Qiang25
  • Paul Robustelli31
  • Leonor Saiz32
  • Omar A. Saleh33
  • Helmut Schießel34,35
  • Jeremy D. Schmit36
  • Meng Shen37
  • Krishna Shrinivas18
  • Antonia Statt38
  • Andrés R. Tejedor15,16,17
  • Tatjana Trcek39
  • Christoph A. Weber22
  • Stephanie C. Weber40
  • Ned S. Wingreen1
  • Huaiying Zhang
  • Yaojun Zhang39
  • Huan‐Xiang Zhou
  • David Zwicker25
40 affiliations
  1. 1Princeton University
  2. 2Faculty of Informatics/Mathematics
  3. 3HTW Dresden
  4. 4Institute of Numerical Mathematics and Optimization
  5. 5TU Bergakademie Freiberg
  6. 6King's College London
  7. 7Baylor College of Medicine
  8. 8Texas Children's Hospital
  9. 9Department of Biochemistry and Molecular Biology
  10. 10Department of Biophysics and Biophysical Chemistry
  11. 11Johns Hopkins School of Medicine
  12. 12University of Modena and Reggio Emilia
  13. 13Massachusetts Institute of Technology
  14. 14University of Toronto
  15. 15Universidad Complutense de Madrid
  16. 16University Complutense of Madrid
  17. 17University of Cambridge
  18. 18Northwestern University
  19. 19University of Chicago
  20. 20Washington University in St. Louis
  21. 21New York University
  22. 22University of Augsburg
  23. 23Max Planck Institute for the Physics of Complex Systems
  24. 24Max Planck Institute for Polymer Research
  25. 25Max Planck Institute for Dynamics and Self-Organization
  26. 26Delft University of Technology
  27. 27Scripps Research Institute
  28. 28University of Pennsylvania
  29. 29GKVK Campus
  30. 30National Centre for Biological Sciences-TIFR
  31. 31Dartmouth College
  32. 32University of California, Davis
  33. 33University of California, Santa Barbara
  34. 34Cluster of Excellence Physics of Life
  35. 35TU Dresden
  36. 36Kansas State University
  37. 37California State University, Fullerton
  38. 38University of Illinois Urbana-Champaign
  39. 39Johns Hopkins University
  40. 40McGill University
Open at sourceDOICite

Abstract

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates.

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Cite

BibTeXRIS
BibTeX
@article{aierken2026roadmap,
  title = {{Roadmap for Condensates in Cell Biology}},
  author = {Dilimulati Aierken and Sebastian Aland and Stefano Bo and Steven Boeynaems and Danfeng Cai and Serena Carra and Lindsay B. Case and Hue Sun Chan and Jorge R. Espinosa and Trevor GrandPre and Alexander Y. Grosberg and Ivar S. Haugerud and William M. Jacobs and Jerelle A. Joseph and Frank Jülicher and Kurt Kremer and Guido L. A. Kusters and Liedewij Laan and Keren Lasker and Kathrin S. Laxhuber and Hyun O. Lee and Kathy F. Liu and Dimple Notani and Yicheng Qiang and Paul Robustelli and Leonor Saiz and Omar A. Saleh and Helmut Schießel and Jeremy D. Schmit and Meng Shen and Krishna Shrinivas and Antonia Statt and Andrés R. Tejedor and Tatjana Trcek and Christoph A. Weber and Stephanie C. Weber and Ned S. Wingreen and Huaiying Zhang and Yaojun Zhang and Huan‐Xiang Zhou and David Zwicker},
  journal = {PRX Life},
  year = {2026},
  month = jul,
  doi = {10.1103/3b2k-ftwx},
  url = {https://doi.org/10.1103/3b2k-ftwx},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Roadmap for Condensates in Cell Biology
AU  - Dilimulati Aierken
AU  - Sebastian Aland
AU  - Stefano Bo
AU  - Steven Boeynaems
AU  - Danfeng Cai
AU  - Serena Carra
AU  - Lindsay B. Case
AU  - Hue Sun Chan
AU  - Jorge R. Espinosa
AU  - Trevor GrandPre
AU  - Alexander Y. Grosberg
AU  - Ivar S. Haugerud
AU  - William M. Jacobs
AU  - Jerelle A. Joseph
AU  - Frank Jülicher
AU  - Kurt Kremer
AU  - Guido L. A. Kusters
AU  - Liedewij Laan
AU  - Keren Lasker
AU  - Kathrin S. Laxhuber
AU  - Hyun O. Lee
AU  - Kathy F. Liu
AU  - Dimple Notani
AU  - Yicheng Qiang
AU  - Paul Robustelli
AU  - Leonor Saiz
AU  - Omar A. Saleh
AU  - Helmut Schießel
AU  - Jeremy D. Schmit
AU  - Meng Shen
AU  - Krishna Shrinivas
AU  - Antonia Statt
AU  - Andrés R. Tejedor
AU  - Tatjana Trcek
AU  - Christoph A. Weber
AU  - Stephanie C. Weber
AU  - Ned S. Wingreen
AU  - Huaiying Zhang
AU  - Yaojun Zhang
AU  - Huan‐Xiang Zhou
AU  - David Zwicker
PY  - 2026
DA  - 2026/07/10
JO  - PRX Life
DO  - 10.1103/3b2k-ftwx
UR  - https://doi.org/10.1103/3b2k-ftwx
AB  - Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates.
SN  - 2835-8279
ER  -