A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease
- 1Icahn School of Medicine at Mount Sinai
Abstract
Alzheimers disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that modifiable factors, such as physical and mental activity, may contribute to cognitive reserve and resilience. To this end, we developed a resilient cohort of paired genetics, transcriptomics and proteomics data from the prefrontal cortex of 282 cognitively normal older adults. We conducted extensive preprocessing and rigorous quality control (QC), including QC on sequence metrics and sample matching across multiomics. This cohort can be leveraged for identification of molecular signatures of cognitive resilience to AD and is freely shared with the research community.
Related
- Deciphering plant stress resilience in different millet crops: from multi-omics discoveries to predictive breeding for climate-resilient crop enhancement
- Multimodal neural correlates of cognitive awareness in aging and Alzheimer’s disease
- Association of temporal and masseter muscle thickness with cognitive function and clinical severity in Alzheimer’s disease: a retrospective study
- Optimizing Cognitive Phenotyping for Genetic Discovery in Alzheimer's Disease: A Simulation-Based Evaluation of Mini-Mental State Examination-Based Decline Measures
- Microbiota-derived metabolite signatures in Alzheimer’s disease across the cognitive aging continuum: a human-focused systematic review and evidence-weighted knowledge graph
BibTeX
@misc{wang2026multiomics,
title = {{A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease}},
author = {E. Wang and B. Xie and M. Wang and Y. Fu and X. Wang and Y. Li and P. Xu and H. Liu and L. Ho and Z. Tu and C. Mobbs and C. Gaiteri and M. E. Ehrlich and D. A. Bennett and V. Haroutunian and J. Peng and B. Zhang},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.02.746746},
url = {https://www.biorxiv.org/content/10.64898/2026.09.02.746746v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease
AU - E. Wang
AU - B. Xie
AU - M. Wang
AU - Y. Fu
AU - X. Wang
AU - Y. Li
AU - P. Xu
AU - H. Liu
AU - L. Ho
AU - Z. Tu
AU - C. Mobbs
AU - C. Gaiteri
AU - M. E. Ehrlich
AU - D. A. Bennett
AU - V. Haroutunian
AU - J. Peng
AU - B. Zhang
PY - 2026
DA - 2026/09/02
PB - bioRxiv
DO - 10.64898/2026.09.02.746746
UR - https://www.biorxiv.org/content/10.64898/2026.09.02.746746v1
AB - Alzheimers disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that modifiable factors, such as physical and mental activity, may contribute to cognitive reserve and resilience. To this end, we developed a resilient cohort of paired genetics, transcriptomics and proteomics data from the prefrontal cortex of 282 cognitively normal older adults. We conducted extensive preprocessing and rigorous quality control (QC), including QC on sequence metrics and sample matching across multiomics. This cohort can be leveraged for identification of molecular signatures of cognitive resilience to AD and is freely shared with the research community.
ER -