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Peer-reviewedCC BY 4.0Reviews in Cardiovascular Medicine

Risk of Short-Term Stroke in Non-High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement vs Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis

  • Haochen Liu1,2
  • Zhidan Xiao3
  • Jiahao Zou1,2
  • Xiaoping Peng1,2
  1. 1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330031 Nanchang, Jiangxi, China
  2. 2Jiangxi Hypertension Research Institute, 330006 Nanchang, Jiangxi, China
  3. 3Jiangxi Medical College, Nanchang University, 330031 Nanchang, Jiangxi, China
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Abstract

Background:: To compare the incidence of stroke at 1 and 2 years following transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR), aiming to inform clinical decision-making regarding the safety and effectiveness of these interventions.

Methods:: A random-effects meta-analysis was conducted including 9 randomized controlled trials (RCTs) with a total of 9865 patients. The primary endpoint was the incidence of stroke at 1 and 2 years post-procedure.

Results:: At 1 year, TAVR was associated with a lower incidence of stroke compared with SAVR (odds ratio (OR), 0.77; 95% confidence interval (CI), 0.61–0.98; p = 0.03). No significant difference was observed at 2 years (OR, 0.87; 95% CI, 0.65–1.17; p = 0.37).

Conclusions:: TAVR significantly reduces the risk of stroke within 1 year post-procedure compared with SAVR; however, this effect was not maintained at 2 years. These findings highlight the early benefit of TAVR, while the long-term advantage requires further investigation.

The PROSPERO Registration:: This study has been registered with PROSPERO, registration number: CRD42025636191, https://www.crd.york.ac.uk/PROSPERO/view/CRD42025636191.

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Cite

BibTeXRIS
BibTeX
@article{liu2026risk,
  title = {{Risk of Short-Term Stroke in Non-High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement vs Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis}},
  author = {Haochen Liu and Zhidan Xiao and Jiahao Zou and Xiaoping Peng},
  journal = {Reviews in Cardiovascular Medicine},
  year = {2026},
  month = sep,
  doi = {10.31083/rcm49672},
  url = {https://doi.org/10.31083/rcm49672},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Risk of Short-Term Stroke in Non-High-Risk Patients Undergoing Transcatheter Aortic Valve Replacement vs Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis
AU  - Haochen Liu
AU  - Zhidan Xiao
AU  - Jiahao Zou
AU  - Xiaoping Peng
PY  - 2026
DA  - 2026/09/30
JO  - Reviews in Cardiovascular Medicine
DO  - 10.31083/rcm49672
UR  - https://doi.org/10.31083/rcm49672
AB  - Background:: To compare the incidence of stroke at 1 and 2 years following transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR), aiming to inform clinical decision-making regarding the safety and effectiveness of these interventions.  Methods:: A random-effects meta-analysis was conducted including 9 randomized controlled trials (RCTs) with a total of 9865 patients. The primary endpoint was the incidence of stroke at 1 and 2 years post-procedure.  Results:: At 1 year, TAVR was associated with a lower incidence of stroke compared with SAVR (odds ratio (OR), 0.77; 95% confidence interval (CI), 0.61–0.98; p = 0.03). No significant difference was observed at 2 years (OR, 0.87; 95% CI, 0.65–1.17; p = 0.37).  Conclusions:: TAVR significantly reduces the risk of stroke within 1 year post-procedure compared with SAVR; however, this effect was not maintained at 2 years. These findings highlight the early benefit of TAVR, while the long-term advantage requires further investigation.  The PROSPERO Registration:: This study has been registered with PROSPERO, registration number: CRD42025636191, https://www.crd.york.ac.uk/PROSPERO/view/CRD42025636191.
SN  - 1530-6550
SN  - 2153-8174
ER  -