The Prognostic Value of Venous Base Excess in Emergency Department Patients with and without Renal Dysfunction
Abstract
. Subgroup Cox models were adjusted for age and sex, and interaction terms between BE categories and renal dysfunction were included to assess effect modification.Results A total of 2,629 patients were included (median age, 77 years; 51% male). The overall in-hospital mortality rate was 10% and differed significantly across the BE groups. In patients with renal dysfunction, the hazard ratios for BE ≤-9 and BE ＞+9 were 11.57 and 7.41, respectively, whereas in those without renal dysfunction, the corresponding values were 16.24 and 4.25. No statistically significant interaction was detected between the BE categories and renal dysfunction.Conclusion Venous BE measured at ED presentation independently predicts in-hospital mortality in an unselected adult population. Venous BE was associated with in-hospital mortality in both patients with and without renal dysfunction. Venous BE is a simple, rapid, and noninvasive biomarker suitable for early risk stratification in emergency settings.
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BibTeX
@article{makinouchi2026prognostic,
title = {{The Prognostic Value of Venous Base Excess in Emergency Department Patients with and without Renal Dysfunction}},
author = {Ryuichiro Makinouchi and Teppei Koyama and Yohei Kita and Shinji Machida and Naohiko Imai},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.7707-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7707-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The Prognostic Value of Venous Base Excess in Emergency Department Patients with and without Renal Dysfunction
AU - Ryuichiro Makinouchi
AU - Teppei Koyama
AU - Yohei Kita
AU - Shinji Machida
AU - Naohiko Imai
PY - 2026
DA - 2026/08/19
JO - Internal Medicine
DO - 10.2169/internalmedicine.7707-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7707-26/_article
AB - . Subgroup Cox models were adjusted for age and sex, and interaction terms between BE categories and renal dysfunction were included to assess effect modification.Results A total of 2,629 patients were included (median age, 77 years; 51% male). The overall in-hospital mortality rate was 10% and differed significantly across the BE groups. In patients with renal dysfunction, the hazard ratios for BE ≤-9 and BE ＞+9 were 11.57 and 7.41, respectively, whereas in those without renal dysfunction, the corresponding values were 16.24 and 4.25. No statistically significant interaction was detected between the BE categories and renal dysfunction.Conclusion Venous BE measured at ED presentation independently predicts in-hospital mortality in an unselected adult population. Venous BE was associated with in-hospital mortality in both patients with and without renal dysfunction. Venous BE is a simple, rapid, and noninvasive biomarker suitable for early risk stratification in emergency settings.
SN - 1349-7235
SN - 0918-2918
ER -