Sex-Based Differences in Clinical Characteristics and Outcomes in Patients with Acute Pulmonary Embolism. An Analysis of 1000 Pulmonary Embolism Response Team Activations
4 affiliations
- 1College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
- 2Corewell Health West, Grand Rapids, Michigan, USA.
- 3Advanced Radiology Services (ARS), Grand Rapids, Michigan, USA.
- 4Emergency Care Specialists (ECS), Grand Rapids, Michigan, USA.
Abstract
Introduction: : Pulmonary embolism (PE) is a leading cause of cardiovascular death, with prior studies suggesting differences in clinical characteristics and risk factors between males and females.
Methods: : We retrospectively analyzed all 1,000 adult patients with confirmed PE evaluated by the Pulmonary Embolism Response Team (PERT) at Corewell Health West from November 2019 to March 2024 to describe sex-based differences in presentation, management, and outcomes. Based on sex, patients were classified by differences in demographic, clinical, biomarker, treatment, and outcome measures, including 30-day and one-year survival.
Results: : Among 1,000 patients, 480 (48%) were female. Females were older (64 vs. 62.4 years; p = 0.028), had higher body mass index (35.5 vs. 32.2; p < 0.001), and more frequently reported hormone use (21% vs. 5%; p < 0.001). Troponin and Pro-BNP elevations were higher in proportion in females, while males were more likely to smoke (26% vs. 15%; p < 0.001) and present with cough (31% vs. 23%; p = 0.005). No significant sex differences were observed in PE severity, catheter-based interventions, inferior vena cava filter placement, or 30-day (females 8.7%, males 5.8%; p = 0.064) and one-year survival (females 85.4%, males 87.9%; p = 0.217).
Conclusion: : Despite differences in baseline characteristics and certain clinical features, PE severity, interventions, and outcomes were similar between sexes in this PERT-managed cohort. This highlights sex-specific variations in presentation without differences in management or outcomes within a standardized multidisciplinary pathway such as PERT.
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BibTeX
@article{obeidat2026sexbased,
title = {{Sex-Based Differences in Clinical Characteristics and Outcomes in Patients with Acute Pulmonary Embolism. An Analysis of 1000 Pulmonary Embolism Response Team Activations}},
author = {Maria Obeidat and Dana Marsy and Erin Vandyke and Glenn Vanotteren and Michael Knox and Wael Berjaoui and Joseph Pitcher and Trevor Cummings and Nabin K. Shrestha and Renzo Loyaga-Rendon and Milena Jani},
journal = {Women's Health Reports},
year = {2026},
month = sep,
doi = {10.1177/26884844261477513},
url = {https://doi.org/10.1177/26884844261477513},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Sex-Based Differences in Clinical Characteristics and Outcomes in Patients with Acute Pulmonary Embolism. An Analysis of 1000 Pulmonary Embolism Response Team Activations
AU - Maria Obeidat
AU - Dana Marsy
AU - Erin Vandyke
AU - Glenn Vanotteren
AU - Michael Knox
AU - Wael Berjaoui
AU - Joseph Pitcher
AU - Trevor Cummings
AU - Nabin K. Shrestha
AU - Renzo Loyaga-Rendon
AU - Milena Jani
PY - 2026
DA - 2026/09/17
JO - Women's Health Reports
DO - 10.1177/26884844261477513
UR - https://doi.org/10.1177/26884844261477513
AB - Introduction: : Pulmonary embolism (PE) is a leading cause of cardiovascular death, with prior studies suggesting differences in clinical characteristics and risk factors between males and females. Methods: : We retrospectively analyzed all 1,000 adult patients with confirmed PE evaluated by the Pulmonary Embolism Response Team (PERT) at Corewell Health West from November 2019 to March 2024 to describe sex-based differences in presentation, management, and outcomes. Based on sex, patients were classified by differences in demographic, clinical, biomarker, treatment, and outcome measures, including 30-day and one-year survival. Results: : Among 1,000 patients, 480 (48%) were female. Females were older (64 vs. 62.4 years; p = 0.028), had higher body mass index (35.5 vs. 32.2; p < 0.001), and more frequently reported hormone use (21% vs. 5%; p < 0.001). Troponin and Pro-BNP elevations were higher in proportion in females, while males were more likely to smoke (26% vs. 15%; p < 0.001) and present with cough (31% vs. 23%; p = 0.005). No significant sex differences were observed in PE severity, catheter-based interventions, inferior vena cava filter placement, or 30-day (females 8.7%, males 5.8%; p = 0.064) and one-year survival (females 85.4%, males 87.9%; p = 0.217). Conclusion: : Despite differences in baseline characteristics and certain clinical features, PE severity, interventions, and outcomes were similar between sexes in this PERT-managed cohort. This highlights sex-specific variations in presentation without differences in management or outcomes within a standardized multidisciplinary pathway such as PERT.
SN - 2688-4844
ER -