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PreprintCC BY-NCChemRxiv

Parahydrogen-induced 15N polarization of nitrate ion

  • Nazim R. Mustafin1,2
  • Dudari B. Burueva1
  • Sergey V. Sviyazov1
  • Nikita V. Chukanov1
  • Alexander A. Guda3
  • Oleg G. Salnikov1
  • Igor V. Koptyug1
  1. 1International Tomography Center SB RAS, 3A Institutskaya St., Novosibirsk, Russia, 630090
  2. 2Novosibirsk State University, 2 Pirogova St., Novosibirsk, Russia, 630090
  3. 3Smart Materials Research Institute, 178/24 Sladkova St., Rostov-on-Don, Russia, 344090
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Abstract

Parahydrogen-induced polarization (PHIP) represents a cost-effective hyperpolarization technique providing dramatic increase of the NMR spectroscopy sensitivity. In particular, hyperpolarized metabolites are employed in various in vivo applications, including cancer diagnostics and grading. In this proof-of-concept study, we present an extension of the PHIP methodology to a key nitrogenous metabolite, the nitrate anion. We report an approach for the production of hyperpolarized nitrate solutions utilizing PHIP by means of the side-arm hydrogenation of propargyl nitrate ester. Through the sequential optimization of hydrogenation, polarization transfer, and hydrolysis procedures, we obtained hyperpolarized nitrate anion with 15 N polarization levels estimated as >2%.

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Cite

BibTeXRIS
BibTeX
@misc{mustafin2026parahydrogeninduced,
  title = {{Parahydrogen-induced 15N polarization of nitrate ion}},
  author = {Nazim R. Mustafin and Dudari B. Burueva and Sergey V. Sviyazov and Nikita V. Chukanov and Alexander A. Guda and Oleg G. Salnikov and Igor V. Koptyug},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009584/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009584/v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Parahydrogen-induced 15N polarization of nitrate ion
AU  - Nazim R. Mustafin
AU  - Dudari B. Burueva
AU  - Sergey V. Sviyazov
AU  - Nikita V. Chukanov
AU  - Alexander A. Guda
AU  - Oleg G. Salnikov
AU  - Igor V. Koptyug
PY  - 2026
DA  - 2026/09/28
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009584/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009584/v1
AB  - Parahydrogen-induced polarization (PHIP) represents a cost-effective hyperpolarization technique providing dramatic increase of the NMR spectroscopy sensitivity. In particular, hyperpolarized metabolites are employed in various in vivo applications, including cancer diagnostics and grading. In this proof-of-concept study, we present an extension of the PHIP methodology to a key nitrogenous metabolite, the nitrate anion. We report an approach for the production of hyperpolarized nitrate solutions utilizing PHIP by means of the side-arm hydrogenation of propargyl nitrate ester. Through the sequential optimization of hydrogenation, polarization transfer, and hydrolysis procedures, we obtained hyperpolarized nitrate anion with 15 N polarization levels estimated as >2%.
ER  -