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Peer-reviewedCC BY 4.0Current Medical Imaging

Giant Hyalinizing Trabecular Tumor of the Thyroid: A Case Report and Literature Review

  • Caihong Wang1
  • Fei Wang2
  • Dan Qin1
  • Yuyu Hua1
  • Ying Yang1
  • Yining Xiang3
  • Jing Wen4
4 affiliations
  1. 1Academy of Medical Imaging, Guizhou Medical University, Guiyang, Guizhou 550004, China
  2. 2Department of Radiology, Luzhou People's Hospital, Luzhou 646000, China
  3. 3Department of Pathology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China
  4. 4Department of Ultrasound Center, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China
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Abstract

Introduction: Hyalinizing Trabecular Tumor (HTT) is an extremely rare thyroid neoplasm. Preoperative imaging diagnosis and Fine-Needle Aspiration Cytology (FNAC) are considerably challenging. We present a case of invasive HTT, describing its clinical course and imaging manifestations.

Case Description: A 49-year-old woman presented with a 12cm left thyroid mass that had been incidentally detected as a 9×8mm nodule ten years previously. Following asymptomatic gradual enlargement, she developed severe dyspnea in March 2024, prompting admission. Physical examination confirmed a large, firm left thyroid mass. Ultrasound (US) was limited by the lesion's size. Dual-Phase Contrast-Enhanced CT (DP-CECT) revealed a 12cm oval mass replacing the left lobe. US-FNAC yielded suspicious for malignancy (TBSRTC Category III). She underwent left thyroid lobectomy and isthmusectomy. Pathology and immunohistochemistry confirmed HTT with focal capsular invasion. The patient recovered uneventfully during follow-up.

Conclusion: Elucidating the characteristic features of HTT will facilitate early diagnosis and clinical intervention, providing valuable insights for future clinical research.

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Cite

BibTeXRIS
BibTeX
@article{wang2026giant,
  title = {{Giant Hyalinizing Trabecular Tumor of the Thyroid: A Case Report and Literature Review}},
  author = {Caihong Wang and Fei Wang and Dan Qin and Yuyu Hua and Ying Yang and Yining Xiang and Jing Wen},
  journal = {Current Medical Imaging},
  year = {2026},
  month = jul,
  doi = {10.2174/0115734056452029260623060307},
  url = {https://doi.org/10.2174/0115734056452029260623060307},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Giant Hyalinizing Trabecular Tumor of the Thyroid: A Case Report and Literature Review
AU  - Caihong Wang
AU  - Fei Wang
AU  - Dan Qin
AU  - Yuyu Hua
AU  - Ying Yang
AU  - Yining Xiang
AU  - Jing Wen
PY  - 2026
DA  - 2026/07/22
JO  - Current Medical Imaging
DO  - 10.2174/0115734056452029260623060307
UR  - https://doi.org/10.2174/0115734056452029260623060307
AB  - Introduction: Hyalinizing Trabecular Tumor (HTT) is an extremely rare thyroid neoplasm. Preoperative imaging diagnosis and Fine-Needle Aspiration Cytology (FNAC) are considerably challenging. We present a case of invasive HTT, describing its clinical course and imaging manifestations.  Case Description: A 49-year-old woman presented with a 12cm left thyroid mass that had been incidentally detected as a 9×8mm nodule ten years previously. Following asymptomatic gradual enlargement, she developed severe dyspnea in March 2024, prompting admission. Physical examination confirmed a large, firm left thyroid mass. Ultrasound (US) was limited by the lesion's size. Dual-Phase Contrast-Enhanced CT (DP-CECT) revealed a 12cm oval mass replacing the left lobe. US-FNAC yielded suspicious for malignancy (TBSRTC Category III). She underwent left thyroid lobectomy and isthmusectomy. Pathology and immunohistochemistry confirmed HTT with focal capsular invasion. The patient recovered uneventfully during follow-up.  Conclusion: Elucidating the characteristic features of HTT will facilitate early diagnosis and clinical intervention, providing valuable insights for future clinical research.
SN  - 1573-4056
ER  -