A general mathematical framework for modelling subnetworks of the nuclear auxin pathway
- 1University of Nottingham
Abstract
Auxins are a family of plant hormones involved in various processes across plant tissues and species. The Nuclear Auxin Pathway (NAP) consists of interacting transcription factors (ARFs) and repressors (Aux/IAAs), which govern an individual cell's response to changes in auxin concentration. These components are present in all land plants, and many species possess multiple copies of each signalling component. We present a general framework for ODE-based models of NAP submodules with the flexibility to model the promotion and repression of target genes by any combination of transcriptional regulators. We analyse published data and show that auxin treatment in Arabidopsis thaliana roots triggers a range of characteristically distinct temporal response profiles-for both target genes and the signalling components themselves. Using our modelling framework, we recapitulate aspects of this behaviour by presenting examples of real and theoretical NAP subnetworks, and by analysing the effect that these network dynamics have on auxin-mediated transcriptional responses. This work demonstrates the utility of our modelling framework as a general-purpose tool for understanding the function of certain protein-protein and protein-DNA interactions through their effects on the NAP. This exploration of the rich dynamics of more complex signalling pathways promises to advance our understanding of the NAP.
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BibTeX
@misc{shuttleworth2026general,
title = {{A general mathematical framework for modelling subnetworks of the nuclear auxin pathway}},
author = {J. G. Shuttleworth and E. Chan and T. Welch and R. G. Bhosale and A. Bishopp and E. Farcot},
howpublished = {bioRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.06.742982},
url = {https://www.biorxiv.org/content/10.64898/2026.08.06.742982v2},
note = {CC BY},
}
RIS
TY - UNPB
TI - A general mathematical framework for modelling subnetworks of the nuclear auxin pathway
AU - J. G. Shuttleworth
AU - E. Chan
AU - T. Welch
AU - R. G. Bhosale
AU - A. Bishopp
AU - E. Farcot
PY - 2026
DA - 2026/08/06
PB - bioRxiv
DO - 10.64898/2026.08.06.742982
UR - https://www.biorxiv.org/content/10.64898/2026.08.06.742982v2
AB - Auxins are a family of plant hormones involved in various processes across plant tissues and species. The Nuclear Auxin Pathway (NAP) consists of interacting transcription factors (ARFs) and repressors (Aux/IAAs), which govern an individual cell's response to changes in auxin concentration. These components are present in all land plants, and many species possess multiple copies of each signalling component. We present a general framework for ODE-based models of NAP submodules with the flexibility to model the promotion and repression of target genes by any combination of transcriptional regulators. We analyse published data and show that auxin treatment in Arabidopsis thaliana roots triggers a range of characteristically distinct temporal response profiles-for both target genes and the signalling components themselves. Using our modelling framework, we recapitulate aspects of this behaviour by presenting examples of real and theoretical NAP subnetworks, and by analysing the effect that these network dynamics have on auxin-mediated transcriptional responses. This work demonstrates the utility of our modelling framework as a general-purpose tool for understanding the function of certain protein-protein and protein-DNA interactions through their effects on the NAP. This exploration of the rich dynamics of more complex signalling pathways promises to advance our understanding of the NAP.
ER -