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Peer-reviewedCC BY 4.0Chronic Respiratory Disease

Prevalence and impact of insomnia in patients with chronic obstructive pulmonary disease

  • Aureliano Ais-Daza1
  • Angel Carmona-Gonzalez1
  • Sofía Gutierrez-Hernandez1
  • Isabel Castillo-Rivillas1
  • Aurelio Arnedillo-Lopez2
  • Aurelio Arnedillo-Muñoz1,3
  1. 1Respiratory Department, Hospital Universitario Puerta del Mar, Cádiz, Spain
  2. 2Psychiatry Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
  3. 3INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz, Cádiz, Spain
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Abstract

Objectives: To determine the prevalence of insomnia in patients with chronic obstructive pulmonary disease (COPD) and evaluate its association with health status, pulmonary function, anxiety/depression, and exacerbations.

Methods: A cross-sectional observational study was conducted including consecutive COPD outpatients. Data collected included sociodemographic and clinical variables, daytime sleepiness (Epworth Sleepiness Scale), quality of life (COPD Assessment Test, CAT), anxiety and depression (HADS), insomnia severity (Insomnia Severity Index, ISI), and exacerbations in the previous year. Multivariable logistic regression analysis was performed to identify independent predictors of insomnia.

Results: A total of 103 patients (77 males, 26 females) were included. Insomnia prevalence was 38.8% (32.5% mild, 55.0% moderate, 12.5% severe). No significant differences in pulmonary function were observed between patients with and without insomnia. However, patients with insomnia had poorer health status (CAT 19.13±8.63 vs. 11.32±8.13; p<0.001), greater daytime sleepiness (Epworth 5.23±3.10 vs. 3.84±2.31; p<0.011), higher anxiety prevalence (61.5% vs. 31.2%; OR=3.533), and more exacerbations (50% vs. 28.6%; OR=2.5; p<0.037). In multivariable analysis, the CAT score was the only independent predictor of insomnia (OR 1.083; 95% CI 1.011–1.160; p = 0.023).

Conclusions: Insomnia is highly prevalent in COPD and is associated with poorer health status, greater daytime sleepiness, increased anxiety, and more frequent exacerbations. Poorer health status was the only independent predictor of insomnia.

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Cite

BibTeXRIS
BibTeX
@article{aisdaza2026prevalence,
  title = {{Prevalence and impact of insomnia in patients with chronic obstructive pulmonary disease}},
  author = {Aureliano Ais-Daza and Angel Carmona-Gonzalez and Sofía Gutierrez-Hernandez and Isabel Castillo-Rivillas and Aurelio Arnedillo-Lopez and Aurelio Arnedillo-Muñoz},
  journal = {Chronic Respiratory Disease},
  year = {2026},
  month = sep,
  doi = {10.1177/14799731261490558},
  url = {https://doi.org/10.1177/14799731261490558},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Prevalence and impact of insomnia in patients with chronic obstructive pulmonary disease
AU  - Aureliano Ais-Daza
AU  - Angel Carmona-Gonzalez
AU  - Sofía Gutierrez-Hernandez
AU  - Isabel Castillo-Rivillas
AU  - Aurelio Arnedillo-Lopez
AU  - Aurelio Arnedillo-Muñoz
PY  - 2026
DA  - 2026/09/18
JO  - Chronic Respiratory Disease
DO  - 10.1177/14799731261490558
UR  - https://doi.org/10.1177/14799731261490558
AB  - Objectives: To determine the prevalence of insomnia in patients with chronic obstructive pulmonary disease (COPD) and evaluate its association with health status, pulmonary function, anxiety/depression, and exacerbations.  Methods: A cross-sectional observational study was conducted including consecutive COPD outpatients. Data collected included sociodemographic and clinical variables, daytime sleepiness (Epworth Sleepiness Scale), quality of life (COPD Assessment Test, CAT), anxiety and depression (HADS), insomnia severity (Insomnia Severity Index, ISI), and exacerbations in the previous year. Multivariable logistic regression analysis was performed to identify independent predictors of insomnia.  Results: A total of 103 patients (77 males, 26 females) were included. Insomnia prevalence was 38.8% (32.5% mild, 55.0% moderate, 12.5% severe). No significant differences in pulmonary function were observed between patients with and without insomnia. However, patients with insomnia had poorer health status (CAT 19.13±8.63 vs. 11.32±8.13; p<0.001), greater daytime sleepiness (Epworth 5.23±3.10 vs. 3.84±2.31; p<0.011), higher anxiety prevalence (61.5% vs. 31.2%; OR=3.533), and more exacerbations (50% vs. 28.6%; OR=2.5; p<0.037). In multivariable analysis, the CAT score was the only independent predictor of insomnia (OR 1.083; 95% CI 1.011–1.160; p = 0.023).  Conclusions: Insomnia is highly prevalent in COPD and is associated with poorer health status, greater daytime sleepiness, increased anxiety, and more frequent exacerbations. Poorer health status was the only independent predictor of insomnia.
SN  - 1479-9723
SN  - 1479-9731
ER  -