Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome.
- 1Department of Anesthesiology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China uestc.edu.cn.
- 2Department of Anesthesiology Wenjiang Hospital of Sichuan Provincial People's Hospital Chengdu Wenjiang District People's Hospital Chengdu China.
- 3Department of Stomatology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu China uestc.edu.cn.
Abstract
Objective
Arterial serum was generally used to uncover shifts in the metabolic profile induced by surgery and anaesthesia. The specific perioperative metabolic alterations in the brain remain largely unknown. We aimed to detect perioperative changes in cerebral metabolism by arteriovenous gradients of circulating metabolites across the brain using liquid chromatography-tandem mass spectrometry (LC-MS) analysis.Methods
The prospective study was conducted at Sichuan Provincial People's Hospital, China. Twenty patients with unilateral pulmonary lesion were recruited. Patients undergoing thoracic surgery were randomised to receive general anaesthesia with sevoflurane or propofol. Blood samples from radial artery and jugular bulb were collected before and after first anaesthetic administration, at the end of 60 min of maintenance of anaesthesia and 60 min after patients regained consciousness. LC-MS-based untargeted metabolomics strategies were used to determine the difference in abundance of circulating metabolites between artery and jugular bulb.Results
A total of 3900 metabolites were detected. Potential critical alterations of metabolites including phosphatidylcholine (PC), phosphatidylethanolamine (PE), choline, isocitrate and lactate and pathways were identified. Brain took up PC and PE in group sevoflurane but secreted these compounds in group propofol. Additionally, propofol was associated with the release of choline and isocitrate from brain. In both groups, lactic acid entered brain intraoperatively.Conclusion
This work may offer a comprehensive mapping of perioperative alterations of cerebral metabolism in patients under general anaesthesia and a new direction for further studies in pharmacology of general anaesthetics and pathogenesis of perioperative brain dysfunction. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2500111204.
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BibTeX
@article{wang2026perioperative,
title = {{Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome.}},
author = {Chenghong Wang and Sike Ma and Xudan Xing and Qian Liu and Yi Yang and Qian Lei and Juan Liao and Peng Li},
journal = {Anesthesiology research and practice},
year = {2026},
month = oct,
doi = {10.1155/anrp/8559251},
url = {https://europepmc.org/article/MED/42921174},
note = {CC BY},
}
RIS
TY - JOUR
TI - Perioperative Cerebral Metabolism in Patients Under General Anaesthesia With Sevoflurane or Propofol: Evaluation of the Arterial and Jugular Bulb Metabolome.
AU - Chenghong Wang
AU - Sike Ma
AU - Xudan Xing
AU - Qian Liu
AU - Yi Yang
AU - Qian Lei
AU - Juan Liao
AU - Peng Li
PY - 2026
DA - 2026/10/23
JO - Anesthesiology research and practice
DO - 10.1155/anrp/8559251
UR - https://europepmc.org/article/MED/42921174
AB - Objective Arterial serum was generally used to uncover shifts in the metabolic profile induced by surgery and anaesthesia. The specific perioperative metabolic alterations in the brain remain largely unknown. We aimed to detect perioperative changes in cerebral metabolism by arteriovenous gradients of circulating metabolites across the brain using liquid chromatography-tandem mass spectrometry (LC-MS) analysis.Methods The prospective study was conducted at Sichuan Provincial People's Hospital, China. Twenty patients with unilateral pulmonary lesion were recruited. Patients undergoing thoracic surgery were randomised to receive general anaesthesia with sevoflurane or propofol. Blood samples from radial artery and jugular bulb were collected before and after first anaesthetic administration, at the end of 60 min of maintenance of anaesthesia and 60 min after patients regained consciousness. LC-MS-based untargeted metabolomics strategies were used to determine the difference in abundance of circulating metabolites between artery and jugular bulb.Results A total of 3900 metabolites were detected. Potential critical alterations of metabolites including phosphatidylcholine (PC), phosphatidylethanolamine (PE), choline, isocitrate and lactate and pathways were identified. Brain took up PC and PE in group sevoflurane but secreted these compounds in group propofol. Additionally, propofol was associated with the release of choline and isocitrate from brain. In both groups, lactic acid entered brain intraoperatively.Conclusion This work may offer a comprehensive mapping of perioperative alterations of cerebral metabolism in patients under general anaesthesia and a new direction for further studies in pharmacology of general anaesthetics and pathogenesis of perioperative brain dysfunction. Trial Registration: Chinese Clinical Trial Registry: ChiCTR2500111204.
SN - 1687-6962
SN - 1687-6970
ER -