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Peer-reviewedCC BY-NC 4.0Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study

  • Arnaud D. Kaze1
  • Chizobam Ani2
  • Ervin R. Fox3
  • Michael E. Hall3
  • Beeletsega T. Yeneneh1
  • Robert J. Mentz4
  • Alain G. Bertoni5
  • Justin B. Echouffo‐Tcheugui6,7
7 affiliations
  1. 1Division of Cardiology, Banner‐University Medical Center Phoenix The University of Arizona College of Medicine Phoenix AZ USA
  2. 2Department of Internal Medicine Charles R Drew University of Medicine and Science Los Angeles CA USA
  3. 3Division of Cardiology, Department of Medicine University of Mississippi Medical Center Jackson MS USA
  4. 4Duke University Medical Center and Duke Clinical Research Institute Durham NC USA
  5. 5Division of Public Health Sciences Wake Forest University School of Medicine Winston‐Salem NC USA
  6. 6Division of Endocrinology, Diabetes & Metabolism, Department of Medicine Johns Hopkins School of Medicine Baltimore MD USA
  7. 7Welch Prevention Center for Prevention, Epidemiology and Clinical Research Johns Hopkins University Baltimore MD USA
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Abstract

Background: Type 2 diabetes is associated with a high risk of heart failure. Hence, precise cardiac imaging can help early detection of subclinical myocardial dysfunction. We investigated the associations of glycemic status and markers with left ventricular (LV) remodeling assessed by cardiac magnetic resonance imaging among Black adults.

Methods: Peak systolic circumferential strain (Eulerian circumferential systolic strain), LV mass, end‐diastolic volume, end‐systolic volume, LV ejection fraction, and LV remodeling index were measured by cardiac magnetic resonance imaging in JHS (Jackson Heart Study) participants between 2008 and 2012. We evaluated the associations of glycemic markers (fasting plasma glucose and hemoglobin A1C) and glycemic status (diabetes, prediabetes, and normoglycemia) with cardiac magnetic resonance imaging measures of LV structure and function.

Results: A total of 1609 Black participants (mean age, 59 years; 63% women; 27.4% with diabetes and 46.8% with prediabetes) were included. Participants with diabetes had higher LV mass (adjusted β, 4.94 [95% CI, 0.51–9.37]), higher LV remodeling index (β, 0.05 [95% CI: 0.01– 0.09]), impaired global circumferential systolic strain (β, 0.44 [95% CI, 0.04–0.84]), and a higher odds of abnormal strain compared with those with normoglycemia (adjusted odds ratio, 1.43 [95% CI, 1.01–2.04]). Each SD increase in hemoglobin A1C was associated with higher LV mass (β, 2.48 [95% CI, 0.76–4.21]), LV remodeling index (β, 0.02 [95% CI, 0.01–0.04]), and impaired global circumferential systolic strain (β, 0.21 [95% CI, 0.06–0.37]).

Conclusions: In a large community‐based cohort of Black individuals, diabetes was associated with differences in LV structure and myocardial strain measured by cardiac magnetic resonance imaging.

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Cite

BibTeXRIS
BibTeX
@article{kaze2026glycemic,
  title = {{Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study}},
  author = {Arnaud D. Kaze and Chizobam Ani and Ervin R. Fox and Michael E. Hall and Beeletsega T. Yeneneh and Robert J. Mentz and Alain G. Bertoni and Justin B. Echouffo‐Tcheugui},
  journal = {Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
  year = {2026},
  month = sep,
  doi = {10.1161/jaha.125.048360},
  url = {https://doi.org/10.1161/jaha.125.048360},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Glycemic Status, Cardiac Structure, and Function by Magnetic Resonance Imaging: The Jackson Heart Study
AU  - Arnaud D. Kaze
AU  - Chizobam Ani
AU  - Ervin R. Fox
AU  - Michael E. Hall
AU  - Beeletsega T. Yeneneh
AU  - Robert J. Mentz
AU  - Alain G. Bertoni
AU  - Justin B. Echouffo‐Tcheugui
PY  - 2026
DA  - 2026/09/24
JO  - Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
DO  - 10.1161/jaha.125.048360
UR  - https://doi.org/10.1161/jaha.125.048360
AB  - Background: Type 2 diabetes is associated with a high risk of heart failure. Hence, precise cardiac imaging can help early detection of subclinical myocardial dysfunction. We investigated the associations of glycemic status and markers with left ventricular (LV) remodeling assessed by cardiac magnetic resonance imaging among Black adults.  Methods: Peak systolic circumferential strain (Eulerian circumferential systolic strain), LV mass, end‐diastolic volume, end‐systolic volume, LV ejection fraction, and LV remodeling index were measured by cardiac magnetic resonance imaging in JHS (Jackson Heart Study) participants between 2008 and 2012. We evaluated the associations of glycemic markers (fasting plasma glucose and hemoglobin A1C) and glycemic status (diabetes, prediabetes, and normoglycemia) with cardiac magnetic resonance imaging measures of LV structure and function.  Results: A total of 1609 Black participants (mean age, 59 years; 63% women; 27.4% with diabetes and 46.8% with prediabetes) were included. Participants with diabetes had higher LV mass (adjusted β, 4.94 [95% CI, 0.51–9.37]), higher LV remodeling index (β, 0.05 [95% CI: 0.01– 0.09]), impaired global circumferential systolic strain (β, 0.44 [95% CI, 0.04–0.84]), and a higher odds of abnormal strain compared with those with normoglycemia (adjusted odds ratio, 1.43 [95% CI, 1.01–2.04]). Each SD increase in hemoglobin A1C was associated with higher LV mass (β, 2.48 [95% CI, 0.76–4.21]), LV remodeling index (β, 0.02 [95% CI, 0.01–0.04]), and impaired global circumferential systolic strain (β, 0.21 [95% CI, 0.06–0.37]).  Conclusions: In a large community‐based cohort of Black individuals, diabetes was associated with differences in LV structure and myocardial strain measured by cardiac magnetic resonance imaging.
SN  - 2047-9980
ER  -