A Dynamic Self-Reporting Metal–Organic Framework System for Catalysis and Real-Time Reaction Monitoring
5 affiliations
- 1Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States
- 2Department of Chemistry, Princeton University, Princeton, New Jersey 08540, United States
- 3Department of Chemistry, Michigan State University, East Lansing, Michigan 44823, United States
- 4Department of Chemistry, The University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
- 5Department of Chemistry, University of Miami, Coral Gables, Florida 33146, United States
Abstract
Modern catalysis research has primarily focused on improving catalyst activity, selectivity, and stability through active-site engineering, microenvironment regulation, and mechanistic understanding. However, the sustainability and efficiency of catalytic processes also depend on the dynamic evolution of reaction systems, including substrate consumption, catalyst deactivation, and product accumulation. Despite their importance, these changes are typically assessed by off-line analysis rather than real-time monitoring, which hinders efficient process optimization and sustainable operation. Here, we develop a dynamic self-reporting (DSR) catalytic system based on Ag@UiO-66-(COOH)2/NDCA that simultaneously functions as a heterogeneous oxidation catalyst and an optical reporter for reaction progress. During oxidation, the emission intensity at 440 nm increases with product formation and exhibits a strong quantitative correlation with benzaldehyde yield, enabling reaction progress to be continuously tracked across a series of substituted benzyl alcohols. Mechanistic studies indicate that the luminescence response is governed by competitive absorption and substrate-dependent interactions. Density functional theory calculations further reveal that benzyl alcohol forms stronger dispersion-stabilized π···π interactions with the emissive NDCA2– linkers than benzaldehyde, resulting in more pronounced luminescence quenching. As benzyl alcohol is converted into the more weakly interacting product, this quenching is progressively relieved, producing a measurable increase in emission intensity that reports the reaction progress. This integration provides a platform for reaction monitoring, process optimization, and future automated manufacturing.
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BibTeX
@article{huo2026dynamic,
title = {{A Dynamic Self-Reporting Metal–Organic Framework System for Catalysis and Real-Time Reaction Monitoring}},
author = {Jiatong Huo and Zongsu Han and Wenxuan Li and Yihao Yang and Zekihan Ozerdem and Narasimhan Loganathan and Xincheng Liu and Joshua Rushlow and Zhaoyi Liu and Angela K. Wilson and Kun-Yu Wang and Hong-Cai Zhou},
journal = {Journal of the American Chemical Society},
year = {2026},
month = oct,
doi = {10.1021/jacs.6c15370},
url = {https://doi.org/10.1021/jacs.6c15370},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - A Dynamic Self-Reporting Metal–Organic Framework System for Catalysis and Real-Time Reaction Monitoring
AU - Jiatong Huo
AU - Zongsu Han
AU - Wenxuan Li
AU - Yihao Yang
AU - Zekihan Ozerdem
AU - Narasimhan Loganathan
AU - Xincheng Liu
AU - Joshua Rushlow
AU - Zhaoyi Liu
AU - Angela K. Wilson
AU - Kun-Yu Wang
AU - Hong-Cai Zhou
PY - 2026
DA - 2026/10/22
JO - Journal of the American Chemical Society
DO - 10.1021/jacs.6c15370
UR - https://doi.org/10.1021/jacs.6c15370
AB - Modern catalysis research has primarily focused on improving catalyst activity, selectivity, and stability through active-site engineering, microenvironment regulation, and mechanistic understanding. However, the sustainability and efficiency of catalytic processes also depend on the dynamic evolution of reaction systems, including substrate consumption, catalyst deactivation, and product accumulation. Despite their importance, these changes are typically assessed by off-line analysis rather than real-time monitoring, which hinders efficient process optimization and sustainable operation. Here, we develop a dynamic self-reporting (DSR) catalytic system based on Ag@UiO-66-(COOH)2/NDCA that simultaneously functions as a heterogeneous oxidation catalyst and an optical reporter for reaction progress. During oxidation, the emission intensity at 440 nm increases with product formation and exhibits a strong quantitative correlation with benzaldehyde yield, enabling reaction progress to be continuously tracked across a series of substituted benzyl alcohols. Mechanistic studies indicate that the luminescence response is governed by competitive absorption and substrate-dependent interactions. Density functional theory calculations further reveal that benzyl alcohol forms stronger dispersion-stabilized π···π interactions with the emissive NDCA2– linkers than benzaldehyde, resulting in more pronounced luminescence quenching. As benzyl alcohol is converted into the more weakly interacting product, this quenching is progressively relieved, producing a measurable increase in emission intensity that reports the reaction progress. This integration provides a platform for reaction monitoring, process optimization, and future automated manufacturing.
SN - 0002-7863
SN - 1520-5126
ER -