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Peer-reviewedCC BYACS Nano

Wireless Electromagnetic Generation of miRNA Sponges and Nerve Stimulation by an Adaptable Electrical Scaffold for Repair of Traumatic Brain Injury

  • Hoi Man Iao1,2
  • Wan‐Chi Pan1,2
  • Yun‐Hsuan Chang1,2
  • Ngoc‐Tri Tran1,2
  • Hsiu‐Ching Liu1,2
  • Ru‐Siou Hsu3,4
  • Tsu‐Chin Chou5,2
  • I‐Chi Lee1,2
  • Lun‐De Liao6,7
  • Wen‐Hsuan Chiang8,9
  • Ssu‐Ju Li3,4
  • Eric Hwang10,11,12,4
3 more authors
  • Ming‐You Shie13,14,15,16,3,17
  • You-Yin Chen3,4
  • Shang-Hsiu Hu1,5,18,2
18 affiliations
  1. 1Department of Biomedical Engineering and Environmental Sciences
  2. 2National Tsing Hua University
  3. 3Department of Biomedical Engineering
  4. 4National Yang Ming Chiao Tung University
  5. 5Institute of Analytical and Environmental Sciences
  6. 6Institute of Biomedical Engineering and Nanomedicine
  7. 7National Health Research Institutes
  8. 8Department of Chemical Engineering
  9. 9National Chung Hsing University
  10. 10Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B)
  11. 11Department of Biological Science and Technology
  12. 12Institute of Molecular Medicine and Bioengineering
  13. 13Asia University
  14. 14China Medical University
  15. 15China Medical University Hospital
  16. 16Department of Bioinformatics and Medical Engineering
  17. 17Xenotransplantation Translational Research Center
  18. 18Institute of Biomedical Engineering
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Abstract

Bioelectronic transduction and microRNA (miRNA) regulation play crucial roles in shaping neuronal cell fate and supporting brain repair. However, clinical progress remains limited due to the lack of tools to perform spatiotemporal regulation of neuronal electrical activity and nonviral gene regulation in vivo. In this study, an adaptable electronic scaffold (AES) that functions both as an antenna and gene transfection agent was developed for neuron miRNA modulation in traumatic brain injury (TBI). The intrinsic properties of AES alleviate inflammation and glial scarring after TBI by suppressing activated microglia and stellate cells. Under high-frequency magnetic field (HFMF) stimulation, the "wireless messenger" generates localized electrical cues that aid in restoring brain function as well as enhancing neuronal uptake of gene therapeutics via electroporation. In neurons, AES-induced Eddy currents and mechanical forces further promote endosome escape and the formation of miRNA sponges both in vitro and in vivo, thereby reducing the increase in miR-6236 levels after neuronal injury. The synergic effects achieve in situ gene modulation, promotes neurite outgrowth, and enhance angiogenesis within the lesion. In whole-brain diffusion-weighted magnetic resonance imaging (dMRI), the signal bundles reveal improved intercortical and cortical stellate fiber connectivity, and a recovery in motor function. In summary, this wirelessly driven gene regulation platform combines miRNA-targeted therapy with bioelectronic stimulation to achieve precise neuroregenerative intervention.

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Cite

BibTeXRIS
BibTeX
@article{iao2026wireless,
  title = {{Wireless Electromagnetic Generation of miRNA Sponges and Nerve Stimulation by an Adaptable Electrical Scaffold for Repair of Traumatic Brain Injury}},
  author = {Hoi Man Iao and Wan‐Chi Pan and Yun‐Hsuan Chang and Ngoc‐Tri Tran and Hsiu‐Ching Liu and Ru‐Siou Hsu and Tsu‐Chin Chou and I‐Chi Lee and Lun‐De Liao and Wen‐Hsuan Chiang and Ssu‐Ju Li and Eric Hwang and Ming‐You Shie and You-Yin Chen and Shang-Hsiu Hu},
  journal = {ACS Nano},
  year = {2026},
  month = may,
  doi = {10.1021/acsnano.6c04759},
  url = {https://doi.org/10.1021/acsnano.6c04759},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Wireless Electromagnetic Generation of miRNA Sponges and Nerve Stimulation by an Adaptable Electrical Scaffold for Repair of Traumatic Brain Injury
AU  - Hoi Man Iao
AU  - Wan‐Chi Pan
AU  - Yun‐Hsuan Chang
AU  - Ngoc‐Tri Tran
AU  - Hsiu‐Ching Liu
AU  - Ru‐Siou Hsu
AU  - Tsu‐Chin Chou
AU  - I‐Chi Lee
AU  - Lun‐De Liao
AU  - Wen‐Hsuan Chiang
AU  - Ssu‐Ju Li
AU  - Eric Hwang
AU  - Ming‐You Shie
AU  - You-Yin Chen
AU  - Shang-Hsiu Hu
PY  - 2026
DA  - 2026/05/25
JO  - ACS Nano
DO  - 10.1021/acsnano.6c04759
UR  - https://doi.org/10.1021/acsnano.6c04759
AB  - Bioelectronic transduction and microRNA (miRNA) regulation play crucial roles in shaping neuronal cell fate and supporting brain repair. However, clinical progress remains limited due to the lack of tools to perform spatiotemporal regulation of neuronal electrical activity and nonviral gene regulation in vivo. In this study, an adaptable electronic scaffold (AES) that functions both as an antenna and gene transfection agent was developed for neuron miRNA modulation in traumatic brain injury (TBI). The intrinsic properties of AES alleviate inflammation and glial scarring after TBI by suppressing activated microglia and stellate cells. Under high-frequency magnetic field (HFMF) stimulation, the "wireless messenger" generates localized electrical cues that aid in restoring brain function as well as enhancing neuronal uptake of gene therapeutics via electroporation. In neurons, AES-induced Eddy currents and mechanical forces further promote endosome escape and the formation of miRNA sponges both in vitro and in vivo, thereby reducing the increase in miR-6236 levels after neuronal injury. The synergic effects achieve in situ gene modulation, promotes neurite outgrowth, and enhance angiogenesis within the lesion. In whole-brain diffusion-weighted magnetic resonance imaging (dMRI), the signal bundles reveal improved intercortical and cortical stellate fiber connectivity, and a recovery in motor function. In summary, this wirelessly driven gene regulation platform combines miRNA-targeted therapy with bioelectronic stimulation to achieve precise neuroregenerative intervention.
SN  - 1936-0851
SN  - 1936-086X
ER  -