Comparison of visual estimation of ventricular systolic function with quantitative echocardiographic markers in newborn infants.
4 affiliations
- 1Neonatal Unit, Homerton University Hospital, Homerton Healthcare NHS Foundation Trust, London, UK. [email protected].
- 2Centre for Genomics and Child Health, Barts and the London School of Medicine and Dentistry, London, UK. [email protected].
- 3Neonatal Unit, Homerton University Hospital, Homerton Healthcare NHS Foundation Trust, London, UK.
- 4Neonatal Unit, Aberdeen Maternity Hospital, NHS Grampian, Aberdeen, UK.
Abstract
Background
Neonatologist-performed echocardiography (NPE) is increasingly practiced. NPE operators typically use visual estimation of systolic function and, if indicated, confirm function using quantitative echocardiographic markers. This exploratory study aims to compare the concordance between qualitative and quantitative echocardiographic markers among NPE and non-NPE operators.Methods
We studied a cohort of newborn infants, undergoing routine NPE by the authors at Homerton University Hospital and Aberdeen Maternity Hospital from April 2024 to October 2024. Blinded NPE and non-NPE operators independently assessed left and right ventricular systolic function visually. We compared visual estimation with standard quantitative echocardiographic markers such as shortening fraction, Simpson's ejection fraction and global longitudinal strain for left ventricle and tricuspid annular plane systolic excursion and fractional area change for right ventricle. We examined the concordance between visual estimation and quantitative echocardiographic markers for biventricular systolic function.Results
Sixty infants with a mean (SD) gestation and birth weight of 34 (6.2) weeks and 2311 (1319) grams respectively were examined. Sensitivity testing for all echocardiographic parameters ranged from 25% to 80% whereas specificity ranged from 38% to 78%. Sensitivity increased with worsening grades of LV dysfunction defined using shortening fraction. While concordance between NPE and non-NPE operator was generally limited across most echocardiographic parameters, test-retest reliability was acceptable for several quantitative measures, including Simpson's ejection fraction, global longitudinal strain and right ventricular fractional area change.Conclusion
Visual estimation may be a useful bedside tool for detecting severe ventricular dysfunction in newborn infants; however; quantitative echocardiographic measures are likely to improve the assessment of mild to moderate dysfunction. Further studies should confirm these findings in a larger cohort with a higher representation of infants with ventricular dysfunction.
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BibTeX
@article{pereira2026comparison,
title = {{Comparison of visual estimation of ventricular systolic function with quantitative echocardiographic markers in newborn infants.}},
author = {Sujith S Pereira and Beena Yeldo and Rachael Fleming and Saulius Satas},
journal = {Echo research and practice},
year = {2026},
month = oct,
doi = {10.1186/s44156-026-00142-2},
url = {https://europepmc.org/article/MED/42928354},
note = {CC BY},
}
RIS
TY - JOUR
TI - Comparison of visual estimation of ventricular systolic function with quantitative echocardiographic markers in newborn infants.
AU - Sujith S Pereira
AU - Beena Yeldo
AU - Rachael Fleming
AU - Saulius Satas
PY - 2026
DA - 2026/10/26
JO - Echo research and practice
DO - 10.1186/s44156-026-00142-2
UR - https://europepmc.org/article/MED/42928354
AB - Background Neonatologist-performed echocardiography (NPE) is increasingly practiced. NPE operators typically use visual estimation of systolic function and, if indicated, confirm function using quantitative echocardiographic markers. This exploratory study aims to compare the concordance between qualitative and quantitative echocardiographic markers among NPE and non-NPE operators.Methods We studied a cohort of newborn infants, undergoing routine NPE by the authors at Homerton University Hospital and Aberdeen Maternity Hospital from April 2024 to October 2024. Blinded NPE and non-NPE operators independently assessed left and right ventricular systolic function visually. We compared visual estimation with standard quantitative echocardiographic markers such as shortening fraction, Simpson's ejection fraction and global longitudinal strain for left ventricle and tricuspid annular plane systolic excursion and fractional area change for right ventricle. We examined the concordance between visual estimation and quantitative echocardiographic markers for biventricular systolic function.Results Sixty infants with a mean (SD) gestation and birth weight of 34 (6.2) weeks and 2311 (1319) grams respectively were examined. Sensitivity testing for all echocardiographic parameters ranged from 25% to 80% whereas specificity ranged from 38% to 78%. Sensitivity increased with worsening grades of LV dysfunction defined using shortening fraction. While concordance between NPE and non-NPE operator was generally limited across most echocardiographic parameters, test-retest reliability was acceptable for several quantitative measures, including Simpson's ejection fraction, global longitudinal strain and right ventricular fractional area change.Conclusion Visual estimation may be a useful bedside tool for detecting severe ventricular dysfunction in newborn infants; however; quantitative echocardiographic measures are likely to improve the assessment of mild to moderate dysfunction. Further studies should confirm these findings in a larger cohort with a higher representation of infants with ventricular dysfunction.
SN - 2055-0464
ER -