Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 42 min ago
Peer-reviewedCC BY 4.0Frontiers in Oncology

ORC1 expression features and its prognostic significance in HBV-associated hepatocellular carcinoma

  • Rong Xie1
  • Qing-Mei Li1
  • Hang Wang1
  • Tu-Mei Su1
  • Qian-Bing Yin1
  • Long Huang1
  • Hong-Qian Liang1
  • Yan-Fei Feng1
  • Zi-Li Lv2
  • Qian Wang1
  • Ming-Hua Su1
  • Bo-Bin Hu1
1 more authors
  • Jian-Ning Jiang1,3,4
4 affiliations
  1. 1Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning
  2. 2Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning
  3. 3Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University), Ministry of Education, Nanning
  4. 4Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Nanning
Read full textPDFDOICite

Abstract

Objective: Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Conventional biomarkers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have diagnostic limitations, particularly for early-stage disease. This study investigated the expression profile of ORC1 in HBV-related liver disease and its association with HBV infection, disease progression, and prognosis.

Methods: 178 participants were recruited: 124 HBV-positive cases (49 HBV-HCC, 33 HBV-cirrhosis, 42 chronic hepatitis B) and 54 HBV-negative controls (35 non-HBV-HCC, 19 hepatic hemangioma). Tissue ORC1 was detected by immunohistochemistry, and serum ORC1 was measured by ELISA in a subset of 17 HBV-HCC patients with available serum. Logistic regression identified factors associated with high ORC1 expression. ROC curves were used to evaluate the discrimination of tissue ORC1, AFP, and DCP for HBV-HCC, and the correlation between ORC1 and tumor diameter was analyzed. TCGA-LIHC data were used for external validation.

Results: Tissue ORC1 was significantly upregulated in HBV-positive patients, and HBV infection was independently associated with high ORC1 expression (P<0. 001). ORC1 expression increased progressively from chronic hepatitis B to cirrhosis to HCC. In a subset of 17 HBV-HCC patients with available serum, tissue and serum ORC1 were moderately correlated (Spearman rs=0. 554, 95% CI 0. 085–0. 822, P = 0. 021). Tissue ORC1 showed moderate discrimination between HBV-HCC and HBV-LC (AUC = 0. 64) and between HBV-HCC and CHB (AUC = 0. 66). ORC1 expression was not significantly associated with tumor diameter ( P >0. 05). High ORC1 expression was associated with poorer overall survival in TCGA-LIHC (HR = 1. 7, P = 0. 0026).

Conclusion: ORC1 upregulation is independently associated with HBV infection and increases with disease progression in HBV-related liver disease. Although tissue ORC1 showed only moderate discrimination for HBV-HCC, high ORC1 expression was associated with poorer overall survival in TCGA-LIHC. These findings suggest that ORC1 is primarily a proliferation- and progression-related marker in HBV-related liver disease.

Related

  1. Prognostic significance of indocyanine green fluorescence patterns in resected hepatocellular carcinoma: a retrospective analysis of prospectively collected data.
    Hyo-Won Ahn, Hyun Soo Kang, Gayoung Kim +7
    Annals of surgical treatment and researchPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  2. Prognostic Significance of Response Dynamics in Atezolizumab plus Bevacizumab-Treated Hepatocellular Carcinoma: A Multicenter Real-World Validation Study.
    Renguo Guan, Kaijun Huang, Zehao Zheng +5
    Liver cancerPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  3. Prognostic significance of EGFR-1 and VEGF-A expression in feline cutaneous squamous cell carcinoma.
    Laís Calazans Menescal Linhares, Marcelo Monte Mor Rangel, Krishna Duro de Oliveira +5
    Frontiers in veterinary sciencePeer-reviewedCC BYFull textGeneral medicineEurope PMCPMC
  4. Identification of hepatitis B virus-associated membrane proteins as prognostic biomarkers for hepatocellular carcinoma based on retrospective analysis of integrated membrane proteomics
    Zichen Liu, Jiaming Wan, Guoli Deng +5
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  5. Association of PON2 and Its S311C Substitution with Tumor Progression and Its Significance as an Immune-Associated Prognostic Indicator in Clear Cell Renal Cell Carcinoma.
    Zhiyu Liu, Wei Yun, Ting Hong +5
    CancersPeer-reviewedCC BYFull textOncologyEurope PMC

Cite

BibTeXRIS
BibTeX
@article{xie2026orc1,
  title = {{ORC1 expression features and its prognostic significance in HBV-associated hepatocellular carcinoma}},
  author = {Rong Xie and Qing-Mei Li and Hang Wang and Tu-Mei Su and Qian-Bing Yin and Long Huang and Hong-Qian Liang and Yan-Fei Feng and Zi-Li Lv and Qian Wang and Ming-Hua Su and Bo-Bin Hu and Jian-Ning Jiang},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1938736},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1938736/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - ORC1 expression features and its prognostic significance in HBV-associated hepatocellular carcinoma
AU  - Rong Xie
AU  - Qing-Mei Li
AU  - Hang Wang
AU  - Tu-Mei Su
AU  - Qian-Bing Yin
AU  - Long Huang
AU  - Hong-Qian Liang
AU  - Yan-Fei Feng
AU  - Zi-Li Lv
AU  - Qian Wang
AU  - Ming-Hua Su
AU  - Bo-Bin Hu
AU  - Jian-Ning Jiang
PY  - 2026
DA  - 2026/10/26
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1938736
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1938736/full
AB  - Objective: Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Conventional biomarkers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have diagnostic limitations, particularly for early-stage disease. This study investigated the expression profile of ORC1 in HBV-related liver disease and its association with HBV infection, disease progression, and prognosis.  Methods: 178 participants were recruited: 124 HBV-positive cases (49 HBV-HCC, 33 HBV-cirrhosis, 42 chronic hepatitis B) and 54 HBV-negative controls (35 non-HBV-HCC, 19 hepatic hemangioma). Tissue ORC1 was detected by immunohistochemistry, and serum ORC1 was measured by ELISA in a subset of 17 HBV-HCC patients with available serum. Logistic regression identified factors associated with high ORC1 expression. ROC curves were used to evaluate the discrimination of tissue ORC1, AFP, and DCP for HBV-HCC, and the correlation between ORC1 and tumor diameter was analyzed. TCGA-LIHC data were used for external validation.  Results: Tissue ORC1 was significantly upregulated in HBV-positive patients, and HBV infection was independently associated with high ORC1 expression (P<0. 001). ORC1 expression increased progressively from chronic hepatitis B to cirrhosis to HCC. In a subset of 17 HBV-HCC patients with available serum, tissue and serum ORC1 were moderately correlated (Spearman rs=0. 554, 95% CI 0. 085–0. 822, P = 0. 021). Tissue ORC1 showed moderate discrimination between HBV-HCC and HBV-LC (AUC = 0. 64) and between HBV-HCC and CHB (AUC = 0. 66). ORC1 expression was not significantly associated with tumor diameter ( P >0. 05). High ORC1 expression was associated with poorer overall survival in TCGA-LIHC (HR = 1. 7, P = 0. 0026).  Conclusion: ORC1 upregulation is independently associated with HBV infection and increases with disease progression in HBV-related liver disease. Although tissue ORC1 showed only moderate discrimination for HBV-HCC, high ORC1 expression was associated with poorer overall survival in TCGA-LIHC. These findings suggest that ORC1 is primarily a proliferation- and progression-related marker in HBV-related liver disease.
SN  - 2234-943X
ER  -