Incidence and risk factors for enteral nutrition intolerance in psychiatric patients with comorbid medical conditions: a retrospective cohort study.
- 1Department of Critical Care Medicine, Nantong Fourth People's Hospital, Nantong, Jiangsu, China.
- 2Hemodialysis Center, Nantong Fourth People's Hospital, Nantong, Jiangsu, China.
Abstract
Background
Critically ill psychiatric patients frequently present with multiple physical comorbidities and poor nutritional status. Enteral nutrition plays a key role in comprehensive critical care, but enteral nutrition intolerance (ENI) is highly prevalent.Aims
To investigate the incidence, independent risk factors, and clinical outcomes of ENI in critically ill psychiatric patients with comorbid physical diseases.Methods
This is a single-center retrospective study. We enrolled 150 consecutive patients admitted between January 2024 and December 2025 who received enteral nutrition for at least 3 days. Data for analysis were sourced from the institutional electronic medical record database. Baseline characteristics, nutritional indicators, psychiatric parameters, comorbidity scores, and treatment-related variables were collected. To detect independent risk factors for ENI, univariate screening was performed first, followed by multivariate logistic regression.Results
The overall incidence of ENI was 54.0% in critically ill psychiatric patients with physical comorbidities. Multivariate logistic regression showed the odds ratio (OR) of serum albumin <25 g/L (OR = 3.26, 95%CI: 2.11-5.04, P<0.001), APACHE II score ≥15 (OR = 2.89, 95%CI: 1.87-4.47, P<0.001), combined use of ≥3 antipsychotic agents (OR = 2.71, 95%CI: 1.75-4.19, P<0.001), schizophrenia (OR = 2.12, 95%CI: 1.43-3.21, P = 0.008), and duration of antibiotic use ≥7 days (OR = 2.18, 95%CI: 1.40-3.38, P = 0.001). ENI was significantly associated with longer hospital stay, lower nutritional goal attainment, more frequent EN interruption, and higher pulmonary infection rates.Conclusion
These findings indicate a high burden of ENI in this vulnerable population. The risk factors include hypoalbuminemia, high APACHE IIscore, combined use of three or more antipsychotic agents, schizophrenia, and prolonged antibiotic therapy.
Related
- Parenteral Nutrition Exposure, Nutritional Trajectory, and Clinical Outcomes in Neonates with Surgical Gastrointestinal Conditions: A Retrospective Cohort Study
- How age and underlying conditions affect incidence of hospitalization and death after documented COVID-19 diagnosis among individuals aged >=20 years, a retrospective cohort study using PCORnet, April 2022 to March 2025
- Prospective Evaluation of Individualized Nutrition Support on the Incidence of High-Output Ileostomy
- Healthcare utilization and medical costs among adults with selected psychiatric disorders: a nationwide retrospective cohort study
- Prenatal cannabis use disorder and postpartum psychiatric emergency department visits: A retrospective cohort study of trends and associations in California, 2016–2021
BibTeX
@article{zhou2026incidence,
title = {{Incidence and risk factors for enteral nutrition intolerance in psychiatric patients with comorbid medical conditions: a retrospective cohort study.}},
author = {Pei Zhou and Dongyan Zhang and Ping Zhang and Jiajia Shi and Xiaomin Liu and Shujuan Jiao and Beibei Wang and Xia Xue},
journal = {Frontiers in psychiatry},
year = {2026},
month = oct,
doi = {10.3389/fpsyt.2026.1904251},
url = {https://europepmc.org/article/MED/42898492},
note = {CC BY},
}
RIS
TY - JOUR
TI - Incidence and risk factors for enteral nutrition intolerance in psychiatric patients with comorbid medical conditions: a retrospective cohort study.
AU - Pei Zhou
AU - Dongyan Zhang
AU - Ping Zhang
AU - Jiajia Shi
AU - Xiaomin Liu
AU - Shujuan Jiao
AU - Beibei Wang
AU - Xia Xue
PY - 2026
DA - 2026/10/05
JO - Frontiers in psychiatry
DO - 10.3389/fpsyt.2026.1904251
UR - https://europepmc.org/article/MED/42898492
AB - Background Critically ill psychiatric patients frequently present with multiple physical comorbidities and poor nutritional status. Enteral nutrition plays a key role in comprehensive critical care, but enteral nutrition intolerance (ENI) is highly prevalent.Aims To investigate the incidence, independent risk factors, and clinical outcomes of ENI in critically ill psychiatric patients with comorbid physical diseases.Methods This is a single-center retrospective study. We enrolled 150 consecutive patients admitted between January 2024 and December 2025 who received enteral nutrition for at least 3 days. Data for analysis were sourced from the institutional electronic medical record database. Baseline characteristics, nutritional indicators, psychiatric parameters, comorbidity scores, and treatment-related variables were collected. To detect independent risk factors for ENI, univariate screening was performed first, followed by multivariate logistic regression.Results The overall incidence of ENI was 54.0% in critically ill psychiatric patients with physical comorbidities. Multivariate logistic regression showed the odds ratio (OR) of serum albumin <25 g/L (OR = 3.26, 95%CI: 2.11-5.04, P<0.001), APACHE II score ≥15 (OR = 2.89, 95%CI: 1.87-4.47, P<0.001), combined use of ≥3 antipsychotic agents (OR = 2.71, 95%CI: 1.75-4.19, P<0.001), schizophrenia (OR = 2.12, 95%CI: 1.43-3.21, P = 0.008), and duration of antibiotic use ≥7 days (OR = 2.18, 95%CI: 1.40-3.38, P = 0.001). ENI was significantly associated with longer hospital stay, lower nutritional goal attainment, more frequent EN interruption, and higher pulmonary infection rates.Conclusion These findings indicate a high burden of ENI in this vulnerable population. The risk factors include hypoalbuminemia, high APACHE IIscore, combined use of three or more antipsychotic agents, schizophrenia, and prolonged antibiotic therapy.
SN - 1664-0640
ER -