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Peer-reviewedCC BYScientific Reports

Alterations in sensory and motor nerve conduction associated with age and osteoarthritis in cats are correlated with functional impairment and somatosensory sensitization

  • Aude Castel1
  • Aliénor Delsart1
  • Colombe Otis1
  • Manuela Lefort-Holguin1
  • Karol-Ann Henry2
  • Maxim Moreau1
  • Bertrand Lussier1
  • Johanne Martel-Pelletier1
  • Jean-Pierre Pelletier1
  • Eric Troncy1
  1. 1Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal
  2. 2Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal
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Abstract

Feline somatosensory impairments associated with aging and osteoarthritis (OA) can be quantified through quantitative sensory testing and nerve conduction (NC). This prospective, randomized and blinded study aimed to compare NC in young healthy (CTRL, n = 6) and older OA (OLD, n = 12) cats. Under temperature-controlled general anesthesia, amplitude and conduction velocity (CV) of mixed tibial/sciatic and ulnar nerves were measured. Structural changes (radiographic score), functional alterations [MI-CAT(V)], neuro-sensitization [paw withdrawal threshold (PWT); and response to mechanical temporal summation (RMTS)] were assessed. Data distribution determined tests for inter-group comparison, and outcome correlations (α = 5%). OLD cats presented higher radiographic and MI-CAT(V) scores, but lower PWT, RMTS, motor CV (–23%), motor (–35%) and sensory (–45%) amplitudes compared to CTRL. Functional alterations correlated strongly with structural changes (r = 0.74, p < 0.001) and age (r = 0.90, p < 0.001), and moderately with neuro-sensitization (p < 0.016). Radiographic and MI-CAT(V) scores correlated negatively with (distal) motor CVs (p < 0.044), and with some motor and sensory amplitudes (p < 0.028). The PWTs correlated positively to motor CVs (p < 0.045). Older OA cats exhibited NC alterations correlated with neuro-sensitization and higher than expected with age alone.

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Cite

BibTeXRIS
BibTeX
@article{castel2026alterations,
  title = {{Alterations in sensory and motor nerve conduction associated with age and osteoarthritis in cats are correlated with functional impairment and somatosensory sensitization}},
  author = {Aude Castel and Aliénor Delsart and Colombe Otis and Manuela Lefort-Holguin and Karol-Ann Henry and Maxim Moreau and Bertrand Lussier and Johanne Martel-Pelletier and Jean-Pierre Pelletier and Eric Troncy},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-60879-y},
  url = {https://doi.org/10.1038/s41598-026-60879-y},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Alterations in sensory and motor nerve conduction associated with age and osteoarthritis in cats are correlated with functional impairment and somatosensory sensitization
AU  - Aude Castel
AU  - Aliénor Delsart
AU  - Colombe Otis
AU  - Manuela Lefort-Holguin
AU  - Karol-Ann Henry
AU  - Maxim Moreau
AU  - Bertrand Lussier
AU  - Johanne Martel-Pelletier
AU  - Jean-Pierre Pelletier
AU  - Eric Troncy
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-60879-y
UR  - https://doi.org/10.1038/s41598-026-60879-y
AB  - Feline somatosensory impairments associated with aging and osteoarthritis (OA) can be quantified through quantitative sensory testing and nerve conduction (NC). This prospective, randomized and blinded study aimed to compare NC in young healthy (CTRL, n = 6) and older OA (OLD, n = 12) cats. Under temperature-controlled general anesthesia, amplitude and conduction velocity (CV) of mixed tibial/sciatic and ulnar nerves were measured. Structural changes (radiographic score), functional alterations [MI-CAT(V)], neuro-sensitization [paw withdrawal threshold (PWT); and response to mechanical temporal summation (RMTS)] were assessed. Data distribution determined tests for inter-group comparison, and outcome correlations (α = 5%). OLD cats presented higher radiographic and MI-CAT(V) scores, but lower PWT, RMTS, motor CV (–23%), motor (–35%) and sensory (–45%) amplitudes compared to CTRL. Functional alterations correlated strongly with structural changes (r = 0.74, p < 0.001) and age (r = 0.90, p < 0.001), and moderately with neuro-sensitization (p < 0.016). Radiographic and MI-CAT(V) scores correlated negatively with (distal) motor CVs (p < 0.044), and with some motor and sensory amplitudes (p < 0.028). The PWTs correlated positively to motor CVs (p < 0.045). Older OA cats exhibited NC alterations correlated with neuro-sensitization and higher than expected with age alone.
SN  - 2045-2322
ER  -