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Peer-reviewedCC BY-NCBMJ open ophthalmology

Unilateral subretinal administration of HORA-PDE6β in patients with retinitis pigmentosa harbouring mutations in the PDE6β gene: study protocol of HORA-PDE6β-001 phase I/II clinical trial.

  • Jean-Baptiste Ducloyer1,2
  • Guylène Le Meur3,2
  • Alexandra Poinas4
  • Fanny Billaud3,2
  • Alexandre Vallon3,2
  • Rudy Chatry-Konig3
  • Lyse Giraud3,2
  • Solène Poivet3,2
  • Catherine Ivan3,2
  • Soraya Saiagh5
  • Maelle Leray6
  • Alexandra Jobert6
7 more authors
  • Aurélie Le Thuaut6
  • Emilie Le Blanc6
  • Catherine Mathis7
  • Sandrine Meunier7
  • Catherine Delva8
  • Michel Weber3,2
  • Pierre Lebranchu3,9
9 affiliations
  1. 1Department of Ophthalmology, CHU Nantes, Nantes, France [email protected].
  2. 2Clinical Investigation Centre CIC1413, CHU Nantes, Nantes, France.
  3. 3Department of Ophthalmology, CHU Nantes, Nantes, France.
  4. 4Department of Investigation and Translational Research, CHU Nantes, Nantes, France.
  5. 5Unit of Cellular and Genetic Therapy, CHU Nantes, Nantes, France.
  6. 6Sponsor's Department, CHU Nantes, Nantes, France.
  7. 7Coave Therapeutics, Paris, France.
  8. 8Inferential, Paris, France.
  9. 9UMR 6004, Laboratoire des Sciences du Numerique de Nantes, Nantes, France.
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Cite

BibTeXRIS
BibTeX
@article{ducloyer2026unilateral,
  title = {{Unilateral subretinal administration of HORA-PDE6β in patients with retinitis pigmentosa harbouring mutations in the PDE6β gene: study protocol of HORA-PDE6β-001 phase I/II clinical trial.}},
  author = {Jean-Baptiste Ducloyer and Guylène Le Meur and Alexandra Poinas and Fanny Billaud and Alexandre Vallon and Rudy Chatry-Konig and Lyse Giraud and Solène Poivet and Catherine Ivan and Soraya Saiagh and Maelle Leray and Alexandra Jobert and Aurélie Le Thuaut and Emilie Le Blanc and Catherine Mathis and Sandrine Meunier and Catherine Delva and Michel Weber and Pierre Lebranchu},
  journal = {BMJ open ophthalmology},
  year = {2026},
  month = oct,
  doi = {10.1136/bmjophth-2025-002592},
  url = {https://europepmc.org/article/MED/42849941},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Unilateral subretinal administration of HORA-PDE6β in patients with retinitis pigmentosa harbouring mutations in the PDE6β gene: study protocol of HORA-PDE6β-001 phase I/II clinical trial.
AU  - Jean-Baptiste Ducloyer
AU  - Guylène Le Meur
AU  - Alexandra Poinas
AU  - Fanny Billaud
AU  - Alexandre Vallon
AU  - Rudy Chatry-Konig
AU  - Lyse Giraud
AU  - Solène Poivet
AU  - Catherine Ivan
AU  - Soraya Saiagh
AU  - Maelle Leray
AU  - Alexandra Jobert
AU  - Aurélie Le Thuaut
AU  - Emilie Le Blanc
AU  - Catherine Mathis
AU  - Sandrine Meunier
AU  - Catherine Delva
AU  - Michel Weber
AU  - Pierre Lebranchu
PY  - 2026
DA  - 2026/10/08
JO  - BMJ open ophthalmology
DO  - 10.1136/bmjophth-2025-002592
UR  - https://europepmc.org/article/MED/42849941
SN  - 2397-3269
ER  -