Can Routine Preoperative Endoscopy and Colonoscopy Be Meaningful for the Surgery and Postoperative Course of Patients with Advanced Ovarian Cancer? A Single-Centre Retrospective Cohort Study.
5 affiliations
- 1Department of Gynecologic Oncology, İzmir Tepecik Training and Research Hospital, University of Health Sciences, 35020 Izmir, Türkiye.
- 2Department of General Surgery, İzmir Tepecik Training and Research Hospital, University of Health Sciences, 35020 Izmir, Türkiye.
- 3Department of Perinatology, İzmir Atatürk Training and Research Hospital, 35360 Izmir, Türkiye.
- 4Department of Gynecologic Oncology, Medical Point Hospital, İzmir University of Economics, 35575 Izmir, Türkiye.
- 5Department of Obstetrics and Gynecology, İzmir Tepecik Training and Research Hospital, University of Health Sciences, 35020 Izmir, Türkiye.
Abstract
Background/Objectives: Bowel resection is often required for complete cytoreduction in advanced ovarian cancer, and some units perform upper gastrointestinal endoscopy and colonoscopy beforehand. We compared the endoscopic biopsy findings with the histopathology of the resected bowel and examined determinants of survival. Methods: Eighty-three consecutive women with FIGO stage III-IV serous ovarian cancer cytoreduced to no macroscopic residual disease between 2015 and 2021 were reviewed retrospectively; all had undergone both examinations and completed adjuvant carboplatin-paclitaxel. Results: Bowel resection was performed in 20 women (24.1%). Serosal involvement was reported in 15 specimens and no tumour in four; mucosal invasion was reported in none (95% CI 0-16.8%). Eighteen patients (21.7%) were biopsied endoscopically; no biopsy was malignant. Over a median follow-up of 72 months, 50 women (60.2%) developed recurrence (28 confirmed histologically and 22 diagnosed from imaging and CA-125; recurrence was ascertained retrospectively, which limits the interpretation of disease-free survival) and 44 (53.0%) died. Recurrence was no more frequent in biopsied than in non-biopsied patients (8/18 vs. 42/65, p = 0.174) or after resection (10/20 vs. 40/63, p = 0.306). Age showed an exploratory association with disease-free (HR 1.03/year, 95% CI 1.00-1.06) and overall survival (HR 1.04, 1.00-1.07). Conclusions: In this cohort, no preoperative endoscopic biopsy was malignant and no resected specimen was reported to show mucosal invasion, supporting a limited role for routine endoscopy in assessing bowel wall involvement; its diagnostic accuracy and its value for excluding a gastrointestinal primary could not be assessed.
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BibTeX
@article{dogan2026routine,
title = {{Can Routine Preoperative Endoscopy and Colonoscopy Be Meaningful for the Surgery and Postoperative Course of Patients with Advanced Ovarian Cancer? A Single-Centre Retrospective Cohort Study.}},
author = {Göktürk Han Doğan and Göksever Akpınar and Anıl Doğukan Tutal and Ceren Sağlam Purut and Ayşe Berin Acar and Mehmet Gökçü and Serhat Sarıkaya and Yunus Emre Purut},
journal = {Diagnostics (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/diagnostics16193221},
url = {https://europepmc.org/article/MED/42882378},
note = {CC BY},
}
RIS
TY - JOUR
TI - Can Routine Preoperative Endoscopy and Colonoscopy Be Meaningful for the Surgery and Postoperative Course of Patients with Advanced Ovarian Cancer? A Single-Centre Retrospective Cohort Study.
AU - Göktürk Han Doğan
AU - Göksever Akpınar
AU - Anıl Doğukan Tutal
AU - Ceren Sağlam Purut
AU - Ayşe Berin Acar
AU - Mehmet Gökçü
AU - Serhat Sarıkaya
AU - Yunus Emre Purut
PY - 2026
DA - 2026/10/05
JO - Diagnostics (Basel, Switzerland)
DO - 10.3390/diagnostics16193221
UR - https://europepmc.org/article/MED/42882378
AB - Background/Objectives: Bowel resection is often required for complete cytoreduction in advanced ovarian cancer, and some units perform upper gastrointestinal endoscopy and colonoscopy beforehand. We compared the endoscopic biopsy findings with the histopathology of the resected bowel and examined determinants of survival. Methods: Eighty-three consecutive women with FIGO stage III-IV serous ovarian cancer cytoreduced to no macroscopic residual disease between 2015 and 2021 were reviewed retrospectively; all had undergone both examinations and completed adjuvant carboplatin-paclitaxel. Results: Bowel resection was performed in 20 women (24.1%). Serosal involvement was reported in 15 specimens and no tumour in four; mucosal invasion was reported in none (95% CI 0-16.8%). Eighteen patients (21.7%) were biopsied endoscopically; no biopsy was malignant. Over a median follow-up of 72 months, 50 women (60.2%) developed recurrence (28 confirmed histologically and 22 diagnosed from imaging and CA-125; recurrence was ascertained retrospectively, which limits the interpretation of disease-free survival) and 44 (53.0%) died. Recurrence was no more frequent in biopsied than in non-biopsied patients (8/18 vs. 42/65, p = 0.174) or after resection (10/20 vs. 40/63, p = 0.306). Age showed an exploratory association with disease-free (HR 1.03/year, 95% CI 1.00-1.06) and overall survival (HR 1.04, 1.00-1.07). Conclusions: In this cohort, no preoperative endoscopic biopsy was malignant and no resected specimen was reported to show mucosal invasion, supporting a limited role for routine endoscopy in assessing bowel wall involvement; its diagnostic accuracy and its value for excluding a gastrointestinal primary could not be assessed.
SN - 2075-4418
ER -