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Peer-reviewedCC BY 4.0PLOS One

Construction of an experimental set up to perform full body micro cannulations of sub-millimetric vessels in an anatomical research setting

  • Michael E. J. Stouthandel1
  • Danial Forouhar2
  • Charlotte Debbaut3
  • Jurgen Deviche4
  • Liesl De Graeve5
  • Bernard Depypere6
  • Maarten Meire7
  • Dominique Adriaens
  • Tom Van Hoof
7 affiliations
  1. 1Department of Human Structure and Repair, Ghent University, Ghent, Belgium
  2. 2Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
  3. 3Evolutionairy Morphology of Vertebrates, Ghent University, Ghent, Belgium
  4. 4IBiTech-bioMMeda, Ghent University, Ghent, Belgium
  5. 5Department of Plastic Surgery, Ghent University Hospital, Ghent, Belgium
  6. 6Breast Clinic, Ghent University Hospital, Ghent, Belgium
  7. 7Department of Oral Health Sciences, Ghent University, Ghent, Belgium
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Abstract

Introduction: A better 3D visualisation of the lymphatic system could provide more accurate cancer treatment approaches, but this requires contrast agent injections. Since lymphatic vessels are very small, cannulations to administer contrast agent are very difficult to perform manually. As such, a dedicated set up for lymphatic vessel micro cannulations is required. Materials and methods: A micromanipulator rig for full body micro cannulations was constructed. The rig consists of an aluminium frame that can be positioned over a dissection table. It combines the micromanipulator with a sliding gantry plate and a double jointed positioning system to provide as many possible angles of approach as possible. Fluid pressure control devices and a surgical microscope can also be included in the set up. Results: Micro cannulations on a full body could successfully be performed using the micromanipulator rig. After only a short learning curve to explore the movement possibilities/range of the device, the micromanipulator rig quickly outperformed manual micro cannulations. Conclusions: Given the short learning curve and the success rate of the micro cannulations with the micromanipulator rig, we would strongly recommend other microvascular researchers to use the micromanipulator rig for future experiments involving micro cannulations.

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Cite

BibTeXRIS
BibTeX
@article{stouthandel2026construction,
  title = {{Construction of an experimental set up to perform full body micro cannulations of sub-millimetric vessels in an anatomical research setting}},
  author = {Michael E. J. Stouthandel and Danial Forouhar and Charlotte Debbaut and Jurgen Deviche and Liesl De Graeve and Bernard Depypere and Maarten Meire and Dominique Adriaens and Tom Van Hoof},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0358264},
  url = {https://doi.org/10.1371/journal.pone.0358264},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Construction of an experimental set up to perform full body micro cannulations of sub-millimetric vessels in an anatomical research setting
AU  - Michael E. J. Stouthandel
AU  - Danial Forouhar
AU  - Charlotte Debbaut
AU  - Jurgen Deviche
AU  - Liesl De Graeve
AU  - Bernard Depypere
AU  - Maarten Meire
AU  - Dominique Adriaens
AU  - Tom Van Hoof
PY  - 2026
DA  - 2026/09/11
JO  - PLOS One
DO  - 10.1371/journal.pone.0358264
UR  - https://doi.org/10.1371/journal.pone.0358264
AB  - Introduction: A better 3D visualisation of the lymphatic system could provide more accurate cancer treatment approaches, but this requires contrast agent injections. Since lymphatic vessels are very small, cannulations to administer contrast agent are very difficult to perform manually. As such, a dedicated set up for lymphatic vessel micro cannulations is required. Materials and methods: A micromanipulator rig for full body micro cannulations was constructed. The rig consists of an aluminium frame that can be positioned over a dissection table. It combines the micromanipulator with a sliding gantry plate and a double jointed positioning system to provide as many possible angles of approach as possible. Fluid pressure control devices and a surgical microscope can also be included in the set up. Results: Micro cannulations on a full body could successfully be performed using the micromanipulator rig. After only a short learning curve to explore the movement possibilities/range of the device, the micromanipulator rig quickly outperformed manual micro cannulations. Conclusions: Given the short learning curve and the success rate of the micro cannulations with the micromanipulator rig, we would strongly recommend other microvascular researchers to use the micromanipulator rig for future experiments involving micro cannulations.
SN  - 1932-6203
ER  -