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Peer-reviewedCC BY 4.0Frontiers in Immunology

Histone modifications in laryngeal squamous cell carcinoma: from epigenetic reprogramming to precision therapy

  • Zexi Lv1,2
  • Qiuping Li3
  • Xiaodong Feng1,2
  1. 1Department of Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine
  2. 2Department of Rehabilitation Medicine, Henan University of Chinese Medicine
  3. 3Department of Traditional Chinese Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
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Abstract

Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck, accounting for the vast majority of laryngeal cancers. Its development involves complex interactions between genetic and epigenetic alterations. Histone post-translational modifications, as a crucial regulatory layer linking intracellular metabolic states, oncogenic signaling, and transcriptional programs, participate in tumor cell proliferation, epithelial-mesenchymal transition, stemness maintenance, metabolic reprogramming, and therapeutic resistance by modulating chromatin conformation, transcription factor accessibility, and gene expression profiles. This study systematically summarizes recent advances in histone acetylation, methylation, lactylation, and other novel histone modifications in LSCC, further discusses crosstalk among different histone modifications and their potential roles in the tumor microenvironment and resistance to radiotherapy, chemotherapy, and immunotherapy, and analyzes therapeutic strategies targeting histone modifications as well as future prospects for single-cell and spatial epigenomics in precision medicine for LSCC, aiming to provide new theoretical foundations for biomarker development and epigenetic-targeted therapies in LSCC.

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Cite

BibTeXRIS
BibTeX
@article{lv2026histone,
  title = {{Histone modifications in laryngeal squamous cell carcinoma: from epigenetic reprogramming to precision therapy}},
  author = {Zexi Lv and Qiuping Li and Xiaodong Feng},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1981328},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1981328/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Histone modifications in laryngeal squamous cell carcinoma: from epigenetic reprogramming to precision therapy
AU  - Zexi Lv
AU  - Qiuping Li
AU  - Xiaodong Feng
PY  - 2026
DA  - 2026/10/08
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1981328
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1981328/full
AB  - Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck, accounting for the vast majority of laryngeal cancers. Its development involves complex interactions between genetic and epigenetic alterations. Histone post-translational modifications, as a crucial regulatory layer linking intracellular metabolic states, oncogenic signaling, and transcriptional programs, participate in tumor cell proliferation, epithelial-mesenchymal transition, stemness maintenance, metabolic reprogramming, and therapeutic resistance by modulating chromatin conformation, transcription factor accessibility, and gene expression profiles. This study systematically summarizes recent advances in histone acetylation, methylation, lactylation, and other novel histone modifications in LSCC, further discusses crosstalk among different histone modifications and their potential roles in the tumor microenvironment and resistance to radiotherapy, chemotherapy, and immunotherapy, and analyzes therapeutic strategies targeting histone modifications as well as future prospects for single-cell and spatial epigenomics in precision medicine for LSCC, aiming to provide new theoretical foundations for biomarker development and epigenetic-targeted therapies in LSCC.
SN  - 1664-3224
ER  -