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Peer-reviewedCC BY-NC-ND 4.0International Journal of Molecular Medicine

Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)

  • Sanmei Nong1
  • Qiudong Huang1
  • Kuibo Huang1
  • Xiao Luo1
  • Yin Huang1
  • Wenlian Zheng1
  • Weiyi Huang2
  • Zhaoyun Liu3
  1. 1Clinical Laboratory, Tiandong County Traditional Chinese Medicine Hospital, Baise, Guangxi 531500, P.R. China
  2. 2Nephrology Department, Tiandong County Traditional Chinese Medicine Hospital, Baise, Guangxi 531500, P.R. China
  3. 3Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
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Abstract

Centrosomal protein 55 (CEP55), a core member of the CEP centrosomal protein family, is a molecule that regulates cytokinesis during the end of cell division and is also extensively involved in multiple physiological processes, including genomic stability maintenance, immune regulation and embryonic development. It has been shown that CEP55 participates in pathological processes such as tumor cell proliferation, invasion, metastasis and immune escape by modulating multiple signaling pathways including PI3K/AKT, NF-κB and JAK/STAT. Furthermore, it exhibits a close correlation with poor prognosis among patients with cancer. In addition, dysregulated CEP55 expression is also implicated in the pathological processes of neurological disorders, reproductive-genetic diseases and chronic metabolic diseases. These findings highlight the potential clinical translational value of CEP55 for disease diagnosis, prognostic evaluation and targeted therapy. Based on recent domestic and international research, the present study systematically reviews the molecular biological properties, expression features and action mechanisms of CEP55 across multi-system diseases, and summarizes its clinical application potential, to provide a theoretical reference for promoting relevant basic research and implementing precise clinical diagnosis and treatment.

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Cite

BibTeXRIS
BibTeX
@article{nong2026centrosomal,
  title = {{Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)}},
  author = {Sanmei Nong and Qiudong Huang and Kuibo Huang and Xiao Luo and Yin Huang and Wenlian Zheng and Weiyi Huang and Zhaoyun Liu},
  journal = {International Journal of Molecular Medicine},
  year = {2026},
  month = oct,
  doi = {10.3892/ijmm.2026.6017},
  url = {https://doi.org/10.3892/ijmm.2026.6017},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)
AU  - Sanmei Nong
AU  - Qiudong Huang
AU  - Kuibo Huang
AU  - Xiao Luo
AU  - Yin Huang
AU  - Wenlian Zheng
AU  - Weiyi Huang
AU  - Zhaoyun Liu
PY  - 2026
DA  - 2026/10/16
JO  - International Journal of Molecular Medicine
DO  - 10.3892/ijmm.2026.6017
UR  - https://doi.org/10.3892/ijmm.2026.6017
AB  - Centrosomal protein 55 (CEP55), a core member of the CEP centrosomal protein family, is a molecule that regulates cytokinesis during the end of cell division and is also extensively involved in multiple physiological processes, including genomic stability maintenance, immune regulation and embryonic development. It has been shown that CEP55 participates in pathological processes such as tumor cell proliferation, invasion, metastasis and immune escape by modulating multiple signaling pathways including PI3K/AKT, NF-κB and JAK/STAT. Furthermore, it exhibits a close correlation with poor prognosis among patients with cancer. In addition, dysregulated CEP55 expression is also implicated in the pathological processes of neurological disorders, reproductive-genetic diseases and chronic metabolic diseases. These findings highlight the potential clinical translational value of CEP55 for disease diagnosis, prognostic evaluation and targeted therapy. Based on recent domestic and international research, the present study systematically reviews the molecular biological properties, expression features and action mechanisms of CEP55 across multi-system diseases, and summarizes its clinical application potential, to provide a theoretical reference for promoting relevant basic research and implementing precise clinical diagnosis and treatment.
SN  - 1107-3756
SN  - 1791-244X
ER  -