Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 18 min ago
Peer-reviewedCC BYRadiology case reports

Probable Loeys-Dietz Syndrome with aortic root dilatation and multiple arterial tortuosity in resource-limited setting : A case report.

  • Nikita Datta1
  • Zakia Akther Zahan2
  • Nafisa Zaman Akhtar3
  • Munim Hasan Choudhury4
  • Amit Hasan5
  • Rifah Anjum Samiha4
  • Md Deluwar Hussen3
5 affiliations
  1. 1Dhaka Medical College, Secretariat Road, Shahbagh, Dhaka, Bangladesh.
  2. 2Dhaka Central International Medical College and Hospital, Shymoli Ring Road, Dhaka, 1207, Bangladesh.
  3. 3Dinajpur Medical College, Dinajpur, Bangladesh.
  4. 4Anwer Khan Modern Medical College Hospital, House: 17, Road: 08, Dhanmondi, Dhaka, 1205, Bangladesh.
  5. 5Sir Salimullah Medical College, Mitford Road, Dhaka, 1100, Bangladesh.
Read full textPDFDOICite

Abstract

Loeys-Dietz Syndrome (LDS) is a rare hereditary connective tissue disorder that is characterized by multisystem disorders predisposing individuals to arterial and aortic aneurysms. We present the case of a 17-year-old Bangladeshi male referred to cardiology for assessment of systemic abnormalities and cardiovascular risk. He presented with craniofacial, musculoskeletal, and cutaneous abnormalities including hypertelorism, mandibular ectopic hair, joint hypermobility with mild thoracic scoliosis, residual talipes equinovarus. He had past medical history of surgically corrected congenital anomalies. Based on clinical and radiological findings, he was diagnosed with clinically suspected Loeys-Dietz Syndrome as genetic testing was unavailable. He was managed through a multidisciplinary approach with regular follow-up. This report adds to literature on Loeys-Dietz Syndrome, emphasizing on aortic root dilatation and carotid artery tortuosity as important clinical and radiological features supporting diagnosis of LDS particularly in young patients presenting with characteristic craniofacial abnormalities or suggestive radiological findings. Early recognition and multidisciplinary management are crucial in resource-limited settings to prevent life-threatening vascular complications.

Related

  1. Splicing Alterations Associated with Multiple Homozygous TNXB Variants in a Patient with Suspected Classical-Like Ehlers–Danlos Syndrome
    Bunta Imanaka, Yuiko Hasegawa, Kazumi Kawato +5
    Biochemical GeneticsPeer-reviewedCC BY-NC-ND 4.0Full textGenetics & genomicsPMC
  2. Idiopathic immune‐mediated polyarthritis in a dog associated with ionised hypercalcaemia and probable ischaemic dermatopathy
    Jeanne Bergeat, Eddy Nassif, Sarah Berger +4
    Veterinary Record Case ReportsPeer-reviewedCC BY-NC-NDFull textGeneral biologyHAL
  3. DNA methylation analysis of aortic wall tissue in ascending aortic dilatation/aneurysm and dissection.
    I A Goncharova, A A Zarubin, A V Markov +5
    Vavilovskii zhurnal genetiki i selektsiiPeer-reviewedCC BYFull textPlant biologyEurope PMC
  4. Case Report: Probable paroxysmal sympathetic hyperactivity during vascular and postoperative critical illness with bilateral white matter abnormalities
    Mozhen Li, Yujie Wei, Zhenhua Cai +5
    Frontiers in NeurosciencePeer-reviewedCC BY 4.0NeuroscienceFrontiersCrossref
  5. Brucella melitensis bacteraemia with lymphoma-like generalised lymphadenopathy and probable secondary haemophagocytic lymphohistiocytosis under biopsy constraints: a case report
    Xiaoqi Liu, Anning Song, Mingxia Li +3
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0Full textImmunologyCrossrefPMC

Cite

BibTeXRIS
BibTeX
@article{datta2026probable,
  title = {{Probable Loeys-Dietz Syndrome with aortic root dilatation and multiple arterial tortuosity in resource-limited setting : A case report.}},
  author = {Nikita Datta and Zakia Akther Zahan and Nafisa Zaman Akhtar and Munim Hasan Choudhury and Amit Hasan and Rifah Anjum Samiha and Md Deluwar Hussen},
  journal = {Radiology case reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.radcr.2026.09.066},
  url = {https://europepmc.org/article/MED/42927235},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Probable Loeys-Dietz Syndrome with aortic root dilatation and multiple arterial tortuosity in resource-limited setting : A case report.
AU  - Nikita Datta
AU  - Zakia Akther Zahan
AU  - Nafisa Zaman Akhtar
AU  - Munim Hasan Choudhury
AU  - Amit Hasan
AU  - Rifah Anjum Samiha
AU  - Md Deluwar Hussen
PY  - 2026
DA  - 2026/10/16
JO  - Radiology case reports
DO  - 10.1016/j.radcr.2026.09.066
UR  - https://europepmc.org/article/MED/42927235
AB  - Loeys-Dietz Syndrome (LDS) is a rare hereditary connective tissue disorder that is characterized by multisystem disorders predisposing individuals to arterial and aortic aneurysms. We present the case of a 17-year-old Bangladeshi male referred to cardiology for assessment of systemic abnormalities and cardiovascular risk. He presented with craniofacial, musculoskeletal, and cutaneous abnormalities including hypertelorism, mandibular ectopic hair, joint hypermobility with mild thoracic scoliosis, residual talipes equinovarus. He had past medical history of surgically corrected congenital anomalies. Based on clinical and radiological findings, he was diagnosed with clinically suspected Loeys-Dietz Syndrome as genetic testing was unavailable. He was managed through a multidisciplinary approach with regular follow-up. This report adds to literature on Loeys-Dietz Syndrome, emphasizing on aortic root dilatation and carotid artery tortuosity as important clinical and radiological features supporting diagnosis of LDS particularly in young patients presenting with characteristic craniofacial abnormalities or suggestive radiological findings. Early recognition and multidisciplinary management are crucial in resource-limited settings to prevent life-threatening vascular complications.
SN  - 1930-0433
ER  -