The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes
- 1Queensland University of Technology
Abstract
The osteocyte network in bone is believed to play an important role for how bone tissues sense and respond to mechanical stimulation. Yet, bone adaptation to mechanical loads is often conceptualised as a simple response to mechanical stimuli, such as Wolff's law, which is based on mechanical variables only and takes no account of the cellular basis of mechanosensation. Wolff's law presumes the existence of a reference mechanical stimulus, the mechanical setpoint, above which bone is added, and under which bone is removed. In this paper, we develop a theory of bone tissue sensing and adaptation based on osteocytes to provide new understanding of the role played by osteocyte signals in mechanical adaptation. In this theory, the mechanical setpoint of Frost's mechanostat is explicitly embodied as osteocyte properties involved in mechanotransduction. The mechanical setpoint is allowed to adapt due to the replacement of osteocytes during remodelling, making the setpoint space and time dependent. We propose a mathematical model to implement this new theory of bone adapation and present numerical simulations of this model to explore how mechanobiological response curves (effective Wolff's laws) are modulated by setpoint adaptation during remodelling. By accounting for varying osteocyte populations within bone tissue, we explore bone adaptation under osteocyte disruptions, which is particularly relevant to age-related bone loss. Our model suggests that biological disruptions of remodelling balance cannot always be compensated by mechanical feedback, and that setpoint adaptation during remodelling may have significant observable consequences, such as hysteresis in bone response signatures that resemble lazy zones.
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BibTeX
@misc{pauchard2026osteostat,
title = {{The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes}},
author = {Y. Pauchard and P. R. Buenzli},
howpublished = {bioRxiv},
year = {2026},
month = jun,
doi = {10.64898/2026.06.23.734120},
url = {https://www.biorxiv.org/content/10.64898/2026.06.23.734120v3},
note = {CC BY},
}
RIS
TY - UNPB
TI - The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes
AU - Y. Pauchard
AU - P. R. Buenzli
PY - 2026
DA - 2026/06/23
PB - bioRxiv
DO - 10.64898/2026.06.23.734120
UR - https://www.biorxiv.org/content/10.64898/2026.06.23.734120v3
AB - The osteocyte network in bone is believed to play an important role for how bone tissues sense and respond to mechanical stimulation. Yet, bone adaptation to mechanical loads is often conceptualised as a simple response to mechanical stimuli, such as Wolff's law, which is based on mechanical variables only and takes no account of the cellular basis of mechanosensation. Wolff's law presumes the existence of a reference mechanical stimulus, the mechanical setpoint, above which bone is added, and under which bone is removed. In this paper, we develop a theory of bone tissue sensing and adaptation based on osteocytes to provide new understanding of the role played by osteocyte signals in mechanical adaptation. In this theory, the mechanical setpoint of Frost's mechanostat is explicitly embodied as osteocyte properties involved in mechanotransduction. The mechanical setpoint is allowed to adapt due to the replacement of osteocytes during remodelling, making the setpoint space and time dependent. We propose a mathematical model to implement this new theory of bone adapation and present numerical simulations of this model to explore how mechanobiological response curves (effective Wolff's laws) are modulated by setpoint adaptation during remodelling. By accounting for varying osteocyte populations within bone tissue, we explore bone adaptation under osteocyte disruptions, which is particularly relevant to age-related bone loss. Our model suggests that biological disruptions of remodelling balance cannot always be compensated by mechanical feedback, and that setpoint adaptation during remodelling may have significant observable consequences, such as hysteresis in bone response signatures that resemble lazy zones.
ER -