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Peer-reviewedCC BYDepression and anxiety

Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study.

  • Magdalena Fryze1
  • Aldona Pietrzak2
  • Radoslaw Mlak3
  • Bartłomiej Wawrzycki2
  • Katarzyna Wertheim-Tysarowska4
  • Fauve C A P van Veen5,6
  • Antoni H Gostynski5,6
6 affiliations
  1. 1Department of Palliative Medicine Collegium Medicum University of Zielona Góra Zielona Góra 65-046 Poland uz.zgora.pl.
  2. 2Department of Dermatology Venereology and Paediatric Dermatology Medical University of Lublin Lublin 20-080 Poland umlub.pl.
  3. 3Department of Laboratory Diagnostics Medical University of Lublin Lublin 20-059 Poland umlub.pl.
  4. 4Department of Medical Genetics Institute of Mother and Child Warsaw 01-211 Poland imid.med.pl.
  5. 5Department of Dermatology Maastricht UMC+ Center of Expertise for Genodermatoses University of Maastricht Maastricht University Medical Center+ Maastricht Netherlands maastrichtuniversity.nl.
  6. 6GROW School for Oncology and Reproduction Maastricht University Maastricht Netherlands maastrichtuniversity.nl.
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Abstract

Background

Epidermal differentiation disorders (EDDs) are rare, chronic skin diseases with significant psychosocial impact on patients and families. Their daily management requires complex care, placing caregivers at risk of stress and anxiety. Few studies have systematically examined anxiety and coping strategies in this group.Objectives

To compare anxiety levels and coping styles between caregivers of children with syndromic or nonsyndromic EDD and caregivers of healthy children.Methods

In this cross-sectional case-control study, 39 caregivers of children with EDD and 39 matched controls were recruited from a dermatology clinic. Anxiety was assessed with the State-Trait Anxiety Inventory (STAI) and coping styles with the Coping Inventory for Stressful Situations (CISS). Sociodemographic and clinical data were collected.Results

Caregivers of children with EDDs reported significantly higher trait anxiety than controls (79.5% vs. 53.8%; p = 0.017). Task-oriented coping (TOC) was less frequent among EDD caregivers, with more than half showing low TOC compared with less than one-third of controls (56.4% vs. 28.6%; p = 0.019). High avoidance-oriented coping (AOC) was observed more often in controls (21.4% vs. 5.6%; p = 0.044). Anxiety was greater among caregivers of boys than girls (95.7% vs. 56.2%; p = 0.003). Avoidant coping was associated with greater child symptom severity, including pruritus and redness.Conclusions

Caregivers of children with EDD experience high anxiety and rely less on adaptive coping strategies. These findings emphasize the need for early, family-centered psychosocial interventions to support caregiver well-being and improve outcomes for affected children.

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Cite

BibTeXRIS
BibTeX
@article{fryze2026anxiety,
  title = {{Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study.}},
  author = {Magdalena Fryze and Aldona Pietrzak and Radoslaw Mlak and Bartłomiej Wawrzycki and Katarzyna Wertheim-Tysarowska and Fauve C A P van Veen and Antoni H Gostynski},
  journal = {Depression and anxiety},
  year = {2026},
  month = oct,
  doi = {10.1155/da/1126242},
  url = {https://europepmc.org/article/MED/42948261},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study.
AU  - Magdalena Fryze
AU  - Aldona Pietrzak
AU  - Radoslaw Mlak
AU  - Bartłomiej Wawrzycki
AU  - Katarzyna Wertheim-Tysarowska
AU  - Fauve C A P van Veen
AU  - Antoni H Gostynski
PY  - 2026
DA  - 2026/10/27
JO  - Depression and anxiety
DO  - 10.1155/da/1126242
UR  - https://europepmc.org/article/MED/42948261
AB  - Background  Epidermal differentiation disorders (EDDs) are rare, chronic skin diseases with significant psychosocial impact on patients and families. Their daily management requires complex care, placing caregivers at risk of stress and anxiety. Few studies have systematically examined anxiety and coping strategies in this group.Objectives  To compare anxiety levels and coping styles between caregivers of children with syndromic or nonsyndromic EDD and caregivers of healthy children.Methods  In this cross-sectional case-control study, 39 caregivers of children with EDD and 39 matched controls were recruited from a dermatology clinic. Anxiety was assessed with the State-Trait Anxiety Inventory (STAI) and coping styles with the Coping Inventory for Stressful Situations (CISS). Sociodemographic and clinical data were collected.Results  Caregivers of children with EDDs reported significantly higher trait anxiety than controls (79.5% vs. 53.8%; p = 0.017). Task-oriented coping (TOC) was less frequent among EDD caregivers, with more than half showing low TOC compared with less than one-third of controls (56.4% vs. 28.6%; p = 0.019). High avoidance-oriented coping (AOC) was observed more often in controls (21.4% vs. 5.6%; p = 0.044). Anxiety was greater among caregivers of boys than girls (95.7% vs. 56.2%; p = 0.003). Avoidant coping was associated with greater child symptom severity, including pruritus and redness.Conclusions  Caregivers of children with EDD experience high anxiety and rely less on adaptive coping strategies. These findings emphasize the need for early, family-centered psychosocial interventions to support caregiver well-being and improve outcomes for affected children.
SN  - 1091-4269
SN  - 1520-6394
ER  -